A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus [v1; ref status: indexed, http://f1000r.es/4qh] by Sean Ekins, Joel S. Freundlich, Megan Coffee

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A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus [v2; ref status: indexed, http://f1000r.es/4wt] by Sean Ekins, Joel S. Freundlich, Megan Coffee

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Mycobacterium tuberculosis KasA as a drug target: Structure-based inhibitor design by Reshma S. Rudraraju, Samer S. Daher, Ricardo Gallardo-Macias, Xin Wang, Matthew B. Neiditch, Joel S. Freundlich, Joel S. Freundlich

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Liquid chromatography-mass spectrometry-based protocol to measure drug accumulation in Mycobacterium tuberculosis and its host cell by Yong-Mo Ahn, Richard C. Lavin, Shumin Tan, Joel S. Freundlich

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Essential Metabolites of <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> and Their Mimics by Gyanu Lamichhane, Joel S. Freundlich, Sean Ekins, Niluka Wickramaratne, Scott T. Nolan, William R. Bishai

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Machine learning models identify molecules active against the Ebola virus in vitro [version 3; referees: 2 approved] by Sean Ekins, Joel S. Freundlich, Alex M. Clark, Manu Anantpadma, Robert A. Davey, Peter Madrid

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Machine learning models identify molecules active against the Ebola virus in vitro [version 1; referees: 2 approved] by Sean Ekins, Joel S. Freundlich, Alex M. Clark, Manu Anantpadma, Robert A. Davey, Peter Madrid

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Machine learning models identify molecules active against the Ebola virus in vitro [version 2; referees: 2 approved] by Sean Ekins, Joel S. Freundlich, Alex M. Clark, Manu Anantpadma, Robert A. Davey, Peter Madrid

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Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection. by Thomas R Lane, Christopher Massey, Jason E Comer, Manu Anantpadma, Joel S Freundlich, Robert A Davey, Peter B Madrid, Sean Ekins

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A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis. by Lauren Forbes, Katherine Ebsworth-Mojica, Louis DiDone, Shao-Gang Li, Joel S Freundlich, Nancy Connell, Paul M Dunman, Damian J Krysan

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Assessment of carbapenems in a mouse model of Mycobacterium tuberculosis infection. by Ravindra Jadhav, Ricardo Gallardo-Macias, Gaurav Kumar, Samer S Daher, Amit Kaushik, Kristina M Bigelow, Eric L Nuermberger, Gyanu Lamichhane, Joel S Freundlich

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Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis. by Satheesh K Palaninathan, Nilofar N Mohamedmohaideen, Elisabetta Orlandini, Gabriella Ortore, Susanna Nencetti, Annalina Lapucci, Armando Rossello, Joel S Freundlich, James C Sacchettini

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Structural basis of DSF recognition by its receptor RpfR and its regulatory interaction with the DSF synthase RpfF. by Evan J Waldron, Daniel Snyder, Nicolas L Fernandez, Emily Sileo, Daigo Inoyama, Joel S Freundlich, Christopher M Waters, Vaughn S Cooper, Matthew B Neiditch

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Computational Approaches to Identify Molecules Binding to Mycobacterium tuberculosis KasA by Ana C. Puhl, Thomas R. Lane, Patricia A. Vignaux, Kimberley M. Zorn, Glenn C. Capodagli, Matthew B. Neiditch, Joel S. Freundlich, Sean Ekins

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Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads by Manu Anantpadma, Thomas Lane, Kimberley M. Zorn, Mary A. Lingerfelt, Alex M. Clark, Joel S. Freundlich, Robert A. Davey, Peter B. Madrid, Sean Ekins

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Open drug discovery for the Zika virus [version 1; referees: 3 approved] by Sean Ekins, Daniel Mietchen, Megan Coffee, Thomas P Stratton, Joel S Freundlich, Lucio Freitas-Junior, Eugene Muratov, Jair Siqueira-Neto, Antony J Williams, Carolina Andrade

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Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery. by Sean Ekins, Peter B Madrid, Malabika Sarker, Shao-Gang Li, Nisha Mittal, Pradeep Kumar, Xin Wang, Thomas P Stratton, Matthew Zimmerman, Carolyn Talcott, Pauline Bourbon, Mike Travers, Maneesh Yadav, Joel S Freundlich

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A Novel Small-Molecule Inhibitor of the <italic toggle="yes">Mycobacterium tuberculosis</italic> Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutr... by Paridhi Sukheja, Pradeep Kumar, Nisha Mittal, Shao-Gang Li, Eric Singleton, Riccardo Russo, Alexander L. Perryman, Riju Shrestha, Divya Awasthi, Seema Husain, Patricia Soteropoulos, Roman Brukh, Nancy Connell, Joel S. Freundlich, David Alland

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Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein. by Reem R Al Olaby, Laurence Cocquerel, Adam Zemla, Laure Saas, Jean Dubuisson, Jost Vielmetter, Joseph Marcotrigiano, Abdul Ghafoor Khan, Felipe Vences Catalan, Alexander L Perryman, Joel S Freundlich, Stefano Forli, Shoshana Levy, Rod Balhorn, Hassan M Azzazy

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Synergistic Lethality of a Binary Inhibitor of <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> KasA by Pradeep Kumar, Glenn C. Capodagli, Divya Awasthi, Riju Shrestha, Karishma Maharaja, Paridhi Sukheja, Shao-Gang Li, Daigo Inoyama, Matthew Zimmerman, Hsin Pin Ho Liang, Jansy Sarathy, Marizel Mina, George Rasic, Riccardo Russo, Alexander L. Perryman, Todd Richmann, Aditi Gupta, Eric Singleton, Sheetal Verma, Seema Husain, Patricia Soteropoulos, Zhe Wang, Roxanne Morris, Gene Porter, Gautam Agnihotri, Padmini Salgame, Sean Ekins, Kyu Y. Rhee, Nancy Connell, Véronique Dartois, Matthew B. Neiditch, Joel S. Freundlich, David Alland

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