Editorial: Neutrophil death regulation in critical illness by Jia-feng Wang, Bing-wei Sun, John C. Marshall, John C. Marshall, John C. Marshall, John C. Marshall

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New translational research provides insights into liver dysfunction in sepsis. by John C Marshall

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Obituary Brian P. Kavanagh, MD by John C. Marshall, Arthur S. Slutsky

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Stakeholder perspectives on adaptive clinical trials: a scoping review by Tina Madani Kia, John C. Marshall, Srinivas Murthy

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The End of “One Size Fits All” Sepsis Therapies: Toward an Individualized Approach by Jean-Louis Vincent, Tom van der Poll, John C. Marshall

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Biomarkers of sepsis: time for a reappraisal by Charalampos Pierrakos, Dimitrios Velissaris, Max Bisdorff, John C. Marshall, Jean-Louis Vincent

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Intracellular and Extracellular Lipopolysaccharide Signaling in Sepsis: Avenues for Novel Therapeutic Strategies by Ramy S. Gabarin, Manshu Li, Paige A. Zimmel, John C. Marshall, Yimin Li, Haibo Zhang

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Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src. by Jennifer Ly Tsang, Song Hui Jia, Jean Parodo, Pamela Plant, Monika Lodyga, Emmanuel Charbonney, Katalin Szaszi, Andras Kapus, John C Marshall

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Distinct host-response signatures in circulatory shock: a narrative review by Sabri Soussi, Claudia dos Santos, Jacob C. Jentzer, Alexandre Mebazaa, Etienne Gayat, Janine Pöss, Hannah Schaubroeck, Filio Billia, John C. Marshall, Patrick R. Lawler

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S100A8/A9 and sRAGE kinetic after polytrauma; an explorative observational study by Philippe Joly, John C. Marshall, Philippe A. Tessier, Chantal Massé, Nathalie Page, Anne Julie Frenette, François Khazoom, Soazig Le Guillan, Yves Berthiaume, Emmanuel Charbonney

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Co-designing and pilot testing an infographic to support patients/families through the REMAP-CAP consent process: a mixed-methods study protocol by Heather K. O’Grady, Zahra Bhimani, Sandra Dalziel, Barbara Dolanjski, Gyan Sandhu, Marlene Santos, Kathy Smith, Srinivas Murthy, John C. Marshall, Michelle E. Kho

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Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery by Anju M. Philip, Youdong Wang, Antonio Mauro, Suzan El-Rass, John C. Marshall, Warren L. Lee, Arthur S. Slutsky, Claudia C. dos Santos, Xiao-Yan Wen

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Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. by Manoj M Lalu, Lauralyn McIntyre, Christina Pugliese, Dean Fergusson, Brent W Winston, John C Marshall, John Granton, Duncan J Stewart, Canadian Critical Care Trials Group

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Circulating Ligands of the Receptor for Advanced Glycation End Products and the Soluble Form of the Receptor Modulate Cardiovascular Cell Apoptosis in Diabetes by James N. Tsoporis, Erifili Hatziagelaki, Sahil Gupta, Shehla Izhar, Vasileos Salpeas, Anastasia Tsiavou, Angelos G. Rigopoulos, Andreas S. Triantafyllis, John C. Marshall, Thomas G. Parker, Ioannis K. Rizos

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A core outcome set for studies evaluating interventions to prevent and/or treat delirium for adults requiring an acute care hospital admission: an international key stakeholder inf... by Louise Rose, Lisa Burry, Meera Agar, Bronagh Blackwood, Noll L. Campbell, Mike Clarke, John W. Devlin, Jacques Lee, John C. Marshall, Dale M. Needham, Najma Siddiqi, Valerie Page

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Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled tri... by Hendrik Rüddel, Daniel O. Thomas-Rüddel, Konrad Reinhart, Friedhelm Bach, Herwig Gerlach, Matthias Lindner, John C. Marshall, Philipp Simon, Manfred Weiss, Frank Bloos, Daniel Schwarzkopf, the MEDUSA study group

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Comparison of the source and prognostic utility of cfDNA in trauma and sepsis by Nicholas L. Jackson Chornenki, Robert Coke, Andrew C. Kwong, Dhruva J. Dwivedi, Michael K. Xu, Ellen McDonald, John C. Marshall, Alison E. Fox-Robichaud, Emmanuel Charbonney, Patricia C. Liaw

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Adjudication of a primary trial outcome: Results of a calibration exercise and protocol for a large international trial by Deborah Cook, Adam Deane, Joanna C. Dionne, François Lauzier, John C. Marshall, Yaseen M. Arabi, M. Elizabeth Wilcox, Marlies Ostermann, Abdulrahman Al-Fares, Diane Heels-Ansdell, Nicole Zytaruk, Lehana Thabane, Simon Finfer

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Association between tocilizumab, sarilumab and all-cause mortality at 28 days in hospitalised patients with COVID-19: A network meta-analysis. by Peter J Godolphin, David J Fisher, Lindsay R Berry, Lennie P G Derde, Janet V Diaz, Anthony C Gordon, Elizabeth Lorenzi, John C Marshall, Srinivas Murthy, Manu Shankar-Hari, Jonathan A C Sterne, Jayne F Tierney, Claire L Vale

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Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury by Hajera Amatullah, Tatiana Maron-Gutierrez, Yuexin Shan, Sahil Gupta, James N. Tsoporis, Amir K. Varkouhi, Ana Paula Teixeira Monteiro, Xiaolin He, Jun Yin, John C. Marshall, Patricia R.M. Rocco, Haibo Zhang, Wolfgang M. Kuebler, Claudia C. dos Santos

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