Molecular insight into the autoinhibition of a master regulator of lipid signalling in human disease by John E. Burke

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Phospholipase A2 structure/function, mechanism, and signaling1 by John E. Burke, Edward A. Dennis

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Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases by Gillian L. Dornan, John E. Burke

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Free energy landscape of the PI3Kα C-terminal activation by Danai Maria Kotzampasi, Michail Papadourakis, John E. Burke, Zoe Cournia

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Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation by Aleksandra Levina, Kaelin D. Fleming, John E. Burke, Thomas A. Leonard

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Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus by Meredith L. Jenkins, Harish Ranga-Prasad, Matthew A. H. Parson, Noah J. Harris, Manoj K. Rathinaswamy, John E. Burke

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Publisher Correction: Crystal structure of a lipin/Pah phosphatidic acid phosphatase by Valerie I. Khayyo, Reece M. Hoffmann, Huan Wang, Justin A. Bell, John E. Burke, Karen Reue, Michael V. Airola

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Crystal structure of an archaeal CorB magnesium transporter by Yu Seby Chen, Guennadi Kozlov, Brandon E. Moeller, Ahmed Rohaim, Rayan Fakih, Benoît Roux, John E. Burke, Kalle Gehring

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Crystal structure of a lipin/Pah phosphatidic acid phosphatase by Valerie I. Khayyo, Reece M. Hoffmann, Huan Wang, Justin A. Bell, John E. Burke, Karen Reue, Michael V. Airola

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Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes by Edhriz Siraliev-Perez, Jordan TB Stariha, Reece M Hoffmann, Brenda RS Temple, Qisheng Zhang, Nicole Hajicek, Meredith L Jenkins, John E Burke, John Sondek

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An intrinsic lipid-binding interface controls sphingosine kinase 1 function[S] by Michael J. Pulkoski-Gross, Meredith L. Jenkins, Jean-Philip Truman, Mohamed F. Salama, Christopher J. Clarke, John E. Burke, Yusuf A. Hannun, Lina M. Obeid

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Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors by Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris, Brandon E Moeller, Matthias P Wymann, Rommie E Amaro, John E Burke

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Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 by Meredith L. Jenkins, Jean Piero Margaria, Jordan T. B. Stariha, Reece M. Hoffmann, Jacob A. McPhail, David J. Hamelin, Martin J. Boulanger, Emilio Hirsch, John E. Burke

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Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents by Nivea Pereira de Sa, Adam Taouil, Jinwoo Kim, Timothy Clement, Reece M. Hoffmann, John E. Burke, Robert C. Rizzo, Iwao Ojima, Maurizio Del Poeta, Michael V. Airola

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The middle lipin domain adopts a membrane-binding dimeric protein fold by Weijing Gu, Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang, Nimi M. Patel, Yong Mi Choi, John E. Burke, Karen Reue, Michael V. Airola

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Biochemical and structural characterization of Rab3GAP reveals insights into Rab18 nucleotide exchange activity by Gage M. J. Fairlie, Kha M. Nguyen, Sung-Eun Nam, Alexandria L. Shaw, Matthew A. H. Parson, Hannah R. Shariati, Xinyin Wang, Meredith L. Jenkins, Michael Gong, John E. Burke, Calvin K. Yip

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Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation by Yong Mi Choi, Dalila Ajjaji, Kaelin D. Fleming, Peter P. Borbat, Meredith L. Jenkins, Brandon E. Moeller, Shaveen Fernando, Surita R. Bhatia, Jack H. Freed, John E. Burke, Abdou Rachid Thiam, Michael V. Airola

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Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain by Noah J Harris, Meredith L Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E Moeller, Eleanor Sheeky, Scott D Hansen, Calvin K Yip, John E Burke

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Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane by Idil Ulengin-Talkish, Matthew A. H. Parson, Meredith L. Jenkins, Jagoree Roy, Alexis Z. L. Shih, Nicole St-Denis, Gergo Gulyas, Tamas Balla, Anne-Claude Gingras, Péter Várnai, Elizabeth Conibear, John E. Burke, Martha S. Cyert

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Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs by Manoj K. Rathinaswamy, Meredith L. Jenkins, Benjamin R. Duewell, Xuxiao Zhang, Noah J. Harris, John T. Evans, Jordan T.B. Stariha, Udit Dalwadi, Kaelin D. Fleming, Harish Ranga-Prasad, Calvin K. Yip, Roger L. Williams, Scott D. Hansen, John E. Burke

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