Nebulised furosemide for the treatment of patients with obstructive lung disease: a systematic review protocol by John Muscedere, Richard Veldhoen

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The frailty, outcomes, recovery and care steps of critically ill patients (FORECAST) study: pilot study results by John Muscedere, Sean M. Bagshaw, Gordon Boyd, Stephanie Sibley, Norman Patrick, Andrew Day, Miranda Hunt, Darryl Rolfson

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Correction: The frailty, outcomes, recovery and care steps of critically ill patients (FORECAST) study: pilot study results by John Muscedere, Sean M. Bagshaw, Gordon Boyd, Stephanie Sibley, Patrick Norman, Andrew Day, Miranda Hunt, Darryl Rolfson

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An international Delphi consensus process to determine a common data element and core outcome set for frailty: FOCUS (The Frailty Outcomes Consensus Project) by Jeanette C. Prorok, Paula R. Williamson, Beverley Shea, Darryl Rolfson, Leocadio Rodriguez Mañas, Matteo Cesari, Perry Kim, John Muscedere

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The relationship between immune status as measured by stimulated ex-vivo tumour necrosis factor alpha levels and the acquisition of nosocomial infections in critically ill mechanic... by Gabrielle Levin, J. Gordon Boyd, Andrew Day, Miranda Hunt, David M. Maslove, Patrick Norman, Nicole O’Callaghan, Stephanie Sibley, John Muscedere

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Models of Care in Geriatric Intensive Care—A Scoping Review on the Optimal Structure of Care for Critically Ill Older Adults Admitted in an ICU by Tasheen Wissanji, MD, MSc, Marie-France Forget, MD, MSc, John Muscedere, MD, Dominique Beaudin, MD, Richard Coveney, MBSI, Han Ting Wang, MD, MSc

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Effectiveness of interventions to address different types of vulnerabilities in community‐dwelling older adults: An umbrella review by Rhéda Adekpedjou, Pascale Léon, Omar Dewidar, Ali Al‐Zubaidi, Jalila Jbilou, Janusz Kaczorowski, John Muscedere, John Hirdes, George Heckman, Magali Girard, Paul C. Hébert

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Ceragenin-coated endotracheal tubes for the reduction of ventilator-associated pneumonia: a prospective, longitudinal, cross-over, interrupted time, implementation study protocol (... by John Muscedere, Andrew Day, David M Maslove, Joanna S Semrau, John Gordon Boyd, Stephanie Sibley, Tracy Boyd, Patrick A Norman, Nicola E Symonds, Eric X M Meng, Hailey Hobbs

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A Frailty Index to Predict Mortality, Resource Utilization and Costs in Patients Undergoing Coronary Artery Bypass Graft Surgery in Ontario by Ana Johnson, PhD, Elizabeth Hore, BSc, Brian Milne, MD, FRCPC, John Muscedere, MD, FRCPC, Yingwei Peng, PhD, Daniel I. McIsaac, MD, FRCPC, Joel Parlow, MD, FRCPC

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Neurological Impairment in Critically Ill Patients on Dialysis: Research Letter for the INCOGNITO-AKI Feasibility Study by Natasha A. Jawa, Samuel A. Silver, Rachel M. Holden, Stephen H. Scott, Andrew G. Day, Patrick A. Norman, Benjamin Y. M. Kwan, David M. Maslove, John Muscedere, J. Gordon Boyd

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Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE) randomised clinical trial: study protocol by Nick Daneman, Deborah J Cook, Richard Hall, John Muscedere, Yaseen M Arabi, Rachael Parke, Steven Reynolds, Asgar H Rishu, Ruxandra L Pinto, Shay McGuinness, Benjamin Rogers, Yahya Shehabi, Robert A Fowler

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The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study. by Rachel D Savage, Robert A Fowler, Asgar H Rishu, Sean M Bagshaw, Deborah Cook, Peter Dodek, Richard Hall, Anand Kumar, François Lamontagne, François Lauzier, John Marshall, Claudio M Martin, Lauralyn McIntyre, John Muscedere, Steven Reynolds, Henry T Stelfox, Nick Daneman

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Association between harm reduction strategies and healthcare utilization in patients on long-term prescribed opioid therapy presenting to acute healthcare settings: a protocol for... by Jean Deschamps, James Gilbertson, Sebastian Straube, Kathryn Dong, Frank P. MacMaster, Christina Korownyk, Lori Montgomery, Ryan Mahaffey, James Downar, Hance Clarke, John Muscedere, Katherine Rittenbach, Robin Featherstone, Meghan Sebastianski, Ben Vandermeer, Deborah Lynam, Ryan Magnussen, Sean M. Bagshaw, Oleksa G. Rewa

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A pilot randomized controlled trial of 7 versus 14 days of antibiotic treatment for bloodstream infection on non-intensive care versus intensive care wards by Nick Daneman, Asgar H. Rishu, Ruxandra Pinto, Yaseen Arabi, Emilie P. Belley-Cote, Robert Cirone, Mark Downing, Deborah J. Cook, Richard Hall, Shay McGuinness, Lauralyn McIntyre, John Muscedere, Rachael Parke, Steven Reynolds, Benjamin A. Rogers, Yahya Shehabi, Phillip Shin, Richard Whitlock, Robert A. Fowler, on behalf of the Canadian Critical Care Trials Group

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FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer’s lactate by John Marshall, Dean A Fergusson, Monica Taljaard, Deborah J Cook, John Muscedere, Charles Weijer, Alan J Forster, Ian D Graham, Kusum Menon, Kednapa Thavorn, Alison Fox-Robichaud, Steven Hawken, Shane W English, Claudio Martin, Andrew Seely, Ian Stiell, Tracy McArdle, Raphael Saginur, Akshai Iyengar, Colin McCartney, Lauralyn Ann McIntyre

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Nebulized Furosemide for Pulmonary Inflammation in Intubated Patients With COVID-19: A Phase 2 Randomized Controlled Double-Blind Study by John Muscedere, MD, David M. Maslove, MD, MS, Christopher J. Barden, PhD, Donald F. Weaver, MD, PhD, J. Gordon Boyd, MD, PhD, Stephanie Sibley, MD, MS, Tracy Boyd, Oleksa Rewa, MD, MSc, Martin Albert, Marios Roussos, MD, MPH, Patrick A. Norman, MSc, Andrew G. Day, MSc, for the Canadian Critical Care Trials Group

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Proton pump inhibitors in critically ill mechanically ventilated patients with COVID-19: protocol for a substudy of the Re-EValuating the Inhibition of Stress Erosions (REVISE) Tri... by Brittany B. Dennis, Lehana Thabane, Diane Heels-Ansdell, Joanna C. Dionne, Alexandra Binnie, Jennifer Tsang, Gordon Guyatt, Aijaz Ahmed, François Lauzier, Adam Deane, Yaseen Arabi, John Marshall, Nicole Zytaruk, Lois Saunders, Simon Finfer, John Myburgh, John Muscedere, Shane English, Marlies Ostermann, Miranda Hardie, Serena Knowles, Deborah Cook, For the REVISE Investigators the Canadian Critical Care Trials Group

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REVISE: re-evaluating the inhibition of stress erosions in the ICU—statistical analysis plan for a randomized trial by Diane Heels-Ansdell, Laurent Billot, Lehana Thabane, Waleed Alhazzani, Adam Deane, Gordon Guyatt, Simon Finfer, François Lauzier, John Myburgh, Paul Young, Yaseen Arabi, John Marshall, Shane English, John Muscedere, Marlies Ostermann, Bala Venkatesh, Nicole Zytaruk, Miranda Hardie, Naomi Hammond, Serena Knowles, Lois Saunders, Alexis Poole, Abdulrahman Al-Fares, Feng Xie, Richard Hall, Deborah Cook

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7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial by Nick Daneman, Asgar H. Rishu, Ruxandra Pinto, Pierre Aslanian, Sean M. Bagshaw, Alex Carignan, Emmanuel Charbonney, Bryan Coburn, Deborah J. Cook, Michael E. Detsky, Peter Dodek, Richard Hall, Anand Kumar, Francois Lamontagne, Francois Lauzier, John C. Marshall, Claudio M. Martin, Lauralyn McIntyre, John Muscedere, Steven Reynolds, Wendy Sligl, Henry T. Stelfox, M. Elizabeth Wilcox, Robert A. Fowler, on behalf of the Canadian Critical Care Trials Group

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REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU: a randomised trial protocol by Lehana Thabane, Gordon Guyatt, Diane Heels-Ansdell, Deborah J Cook, Yaseen Arabi, John Muscedere, Paul Young, Feng Xie, François Lauzier, Laurent Billot, Waleed Alhazzani, Marlies Ostermann, Shane English, Daniel Johnson, John C Marshall, Nicole Zytaruk, Balasubramanian Venkatesh, Simon Finfer, John Myburgh, R Hall, Mobeen Iqbal, Abdulrahman A Al-Fares, Gilmar Reis, Alexis Poole, Adam M Deane, Marianne J Chapman, Dorrilyn Rajbhandari, Naomi E Hammond, Serena Knowles, Miranda Hardie, Lois Saunders

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