What challenges still exist in the critical care of children? -н Fola Odetola, John Pappachan

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High-Flow Humidified Oxygen as an Early Intervention in Children With Acute Severe Asthma: Protocol for a Feasibility Randomized Controlled Trial -н Hector Rojas-Anaya, Akshat Kapur, Graham Roberts, Damian Roland, Atul Gupta, Michaela Lazner, Jane Bayreuther, John Pappachan, Christina Jones, Stephen Bremner, Fleur Cantle, Paul Seddon

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High-flow humidified oxygen as an early intervention in children with acute severe asthma: a feasibility randomised controlled trial -н Akshat Kapur, Héctor Rojas-Anaya, Graham Roberts, Damian Roland, Atul Gupta, Michaela Lazner, Jane Bayreuther, Fleur Cantle, Christina Jones, John Pappachan, Stephen Bremner, David James, Shane Fitzgerald, Kelly Owens, Lalarukh Asim, Ekaterina Khaleva, Paul Seddon

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Use of selective gut decontamination in critically ill children: protocol for the Paediatric Intensive Care and Infection Control (PICnIC) pilot study -н Kerry Woolfall, Nazima Pathan, Lyvonne N Tume, John Pappachan, Kathryn M Rowan, Richard Feltbower, Mariana Popa, David A Harrison, Paloma Ferrando, Brian Cuthbertson, Laura Drikite, Paul R Mouncey, John Myburgh, Theodore Gouliouris, Alanna Brown, Gema Milla de la Fuente, Isobel Sale, Robert Shulman

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Use of selective gut decontamination in critically ill children: PICnIC a pilot RCT and mixed-methods study -н Alanna Brown, Paloma Ferrando-Vivas, Mariana Popa, Gema Milla de la Fuente, John Pappachan, Brian H Cuthbertson, Laura Drikite, Richard Feltbower, Theodore Gouliouris, Isobel Sale, Robert Shulman, Lyvonne N Tume, John Myburgh, Kerry Woolfall, David A Harrison, Paul R Mouncey, Kathryn Rowan, Nazima Pathan

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Selective digestive tract decontamination to prevent healthcare associated infections in critically ill children: the PICNIC multicentre randomised pilot clinical trial -н Nazima Pathan, Kerry Woolfall, Mariana Popa, Gema Milla de la Fuente, Paloma Ferrando-Vivas, Alanna Brown, Theodore Gouliouris, Lyvonne N. Tume, Robert Shulman, Brian H. Cuthbertson, Isobel Sale, Richard G. Feltbower, John Myburgh, John Pappachan, David Harrison, Paul Mouncey, Kathryn Rowan, the PICNIC study investigators

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A clinical and economic evaluation of Control of Hyperglycaemia in Paediatric intensive care (CHiP): a randomised controlled trial -н Duncan Macrae, Richard Grieve, Elizabeth Allen, Zia Sadique, Helen Betts, Kevin Morris, Vithayathil John Pappachan, Roger Parslow, Robert C Tasker, Paul Baines, Michael Broadhead, Mark L Duthie, Peter-Marc Fortune, David Inwald, Paddy McMaster, Mark J Peters, Margrid Schindler, Carla Guerriero, Deborah Piercy, Zdenek Slavik, Claire Snowdon, Laura Van Dyck, Diana Elbourne

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Mechanical power in pediatric acute respiratory distress syndrome: a PARDIE study -н Anoopindar K. Bhalla, Margaret J. Klein, Vicent Modesto I Alapont, Guillaume Emeriaud, Martin C. J. Kneyber, Alberto Medina, Pablo Cruces, Franco Diaz, Muneyuki Takeuchi, Aline B. Maddux, Peter M. Mourani, Cristina Camilo, Benjamin R. White, Nadir Yehya, John Pappachan, Matteo Di Nardo, Steven Shein, Christopher Newth, Robinder Khemani, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

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Outcome monitoring and risk stratification after cardiac procedure in neonates, infants, children and young adults born with congenital heart disease: protocol for a multicentre pr... -н Orhan Uzun, Demetris Taliotis, Umberto Benedetto, Gianni Angelini, Massimo Caputo, Serban Stoica, John Pappachan, Karen Luyt, Mai Baquedano, Deborah A Lawlor, Andrew R Bamber, Gavin J Murphy, Samantha E de Jesus, Andrew D Mumford, Alison Perry, Damien Kenny, Filippo Rapetto, Patricia Caldas, Prashant K Srivastava, Cecilia Gonzalez Corcia, Katie L Skeffington, Ikenna Omeje, Richard J M Coward

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NEUROlogical Prognosis After Cardiac Arrest in Kids (NEUROPACK) study: protocol for a prospective multicentre clinical prediction model derivation and validation study in children... -н Elizabeth S Draper, John Pappachan, Kent Thorburn, David Inwald, Richard Feltbower, Buvana Dwarakanathan, Patrick Davies, Kate Penny-Thomas, James Martin, Rum Thomas, Kevin P Morris, Roger Parslow, Timothy Thiruchelvam, Sophie Skellett, Hari Krishnan Kanthimathinathan, Victoria Hiley, Peter Barry, Sian Cooper, Rohit Saxena, Cormac Breatnach, Barnaby Robert Scholefield, Sarah Evans, Mirjam Kool, Alice J Sitch, Fang Smith, Yamuna Thiru, Richard Levin, Rachel Agbecko, James Weitz, Akash Deep, Sandra Gala-Peralta, Milly Lo, Rachael Barber, Stewart Reid, Siva Oruganti, Kalai Sadasivam, Mark Bebbington

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Evaluation of efficacy, outcomes and safety of infant haemodialysis and ultrafiltration in clinical use: I-KID a stepped wedge cluster RCT -н Heather Lambert, Shaun Hiu, Malcolm Coulthard, John N S Matthews, Ruth Wood, Jean Crosier, Rachel Agbeko, Thomas Brick, Heather Duncan, David Grant, Quen Mok, Andrew Gustaf Nyman, John Pappachan, Paul Wellman, Chris Boucher, Joe Bulmer, Denise Chisholm, Kirsten Cromie, Victoria Emmet, Richard Feltbower, Michael Grayling, Rebecca Harrison, Eva-Maria Holstein, Ciara A Kennedy, Elaine McColl, Kevin Morris, Lee Norman, Julie Office, Roger Parslow, Christine Pattinson, Shriya Sharma, Jonathan Smith, Alison Steel, Rachel Steel, Jayne Straker, Lamprini Vrana, Jenn Walker, Mike Whitaker, Jim Wightman, Nina Wilson, Lucy Wirz

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Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes—an international multicentre retrospective studyResearch in context -н Roelie M. Wösten-van Asperen, Hannah M. la Roi-Teeuw, Rombout BE. van Amstel, Lieuwe DJ. Bos, Wim JE. Tissing, Iolanda Jordan, Christian Dohna-Schwake, Gabriella Bottari, John Pappachan, Roman Crazzolara, Rosanna I. Comoretto, Agniezka Mizia-Malarz, Andrea Moscatelli, María Sánchez-Martín, Jef Willems, Colin M. Rogerson, Tellen D. Bennett, Yuan Luo, Mihir R. Atreya, E.Vincent S. Faustino, Alon Geva, Scott L. Weiss, Luregn J. Schlapbach, L Nelson Sanchez-Pinto, Marina Caballero, Adriana Margarit, Roi Campos, Paula Möller, Carmela Serpe, Angela Amigoni, Maria Damps, Alessia Montaguti, Giacomo Tardini, Juliane Bubeck-Wardenburg, Reid Farris Farris, Mark Hall, Grace Chong, Sareen Shah, Robinder Khemani, Emily Stroup

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Organizational characteristics of European pediatric onco-critical care: An international cross-sectional survey -н Jeppe S. A. Nielsen, Rachel Agbeko, Jessica Bate, Iolanda Jordan, Christian Dohna-Schwake, Jenny Potratz, Andrea Moscatelli, Gabriella Bottari, John Pappachan, Volker Witt, Roman Crazzolara, Angela Amigoni, Agniezka Mizia-Malarz, Mariá Sánchez Martín, Jef Willems, Marry M. van den Heuvel-Eibrink, Luregn J. Schlapbach, Roelie M. Wösten-van Asperen, the POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric & Neonatal Intensive Care), Joe Brierley, Simon Nadel, Omer Aziz, Mark Worrall, Diana McIntosh, Simon Vieth, Eva Tschiedel, Frédéric Valla, Solenn Remy, Frida Rizzati, Andrea Titieni, Emanuele Rossetti, Fabio Caramelli, Maria Cristina Mondardini, Alessia Montaguti

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Stakeholders’ perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study -н Matthew Peak, Kerry Woolfall, Michael Griksaitis, Clare Fowler, Simon Gates, Christopher Lamb, Elizabeth Deja, Rachel Agbeko, John Pappachan, Helen Parker, Jennifer Preston, Ahmed Osman, Paula Williamson, Paul S McNamara, Mark Turner, David Armstrong, Tracy Moitt, Ramesh Kumar, John Alexander, Kevin P Morris, Roger Parslow, Steve Cunningham, Craig Knott, Chloe Donohue, Catrin Barker, Julie Richardson, Ashley Jones, Stephanie Clarke, Malcolm G Semple, Richard Levin, James Weitz, Natasha Roberts, Vanessa Compton, Kentigern Thorburn, PHILIP MILNER, Howard W Clark, Bessie Cipriano, Nosheen Khalid, Nicolene Plaatjies, Avishay Sarfatti, Mark Terris, Santosh Sundararajan, Edgar Brincat, Natasha Thorn, Ramiya Kirupananthan, Peter J Davis, Samantha Owen, Pavanasam Ramesh, Sarah Fox, Laura Price, Hannah Clarke, Charlotte Thompson, Wendy Browne, Constantinos Kanaris, Christine Mackerness, Laura Rad, Grace Williamson, Simone Paulson, Laura O'Malley, Zoe Oliver, Evette Allen, Clare van Miert, Ashley Best, Jens Madsen, Anne Dawson, Colin Summers, Blessing Osaghae, Madhuri Panchal, Anthony Postle, Peter Jirasek, Dawn Jones, Michael Mander, Laura Rimmer, Paul C Ritson, Chris Simons, Afeda Mohamed Ali, Cara Alexander, Hannah Child, Natalie Milburn, Holly Parkin, Harriet Payne, Carly Tooke, Helen Winmill, Katherine Baptiste, Sophie Coles, Sarah-Jayne Eames, Christina Linton, Helen Marley, Sarah Mogan, Alvin Schadenberg, John Stiven, Rob Claydon, Anna Stancombe, Kate Teeley, Kathryn Reeves, Emily Scriven, Raghu N Ramaiah, Rekha Patel, Patrick E Davies, Lindsay Crate, Kirsten Beadon, Rachel McMinnis, Frances Sinfield, Hilary Callaghan, Vicki Linton, Jeremy Lyons, Clara Nelson, Tsz-YanMilly Lo, Jackie McCormick, Andrea Wood, Ross Marscheider, Stephen D Playfor, Bernadette C Gavin, Dave J Morgan, Lara T Bunni, Claire F Jennings, Rebecca Marshall, Emma K Riley, Lorena Caruana, Amber Cook, Tracey Curtis, Nichola Etherington, Jenni McCorkell, Christie Mellish, Jenny Pond, Catherine Postlethwaite, Nicola McClelland, Holly Minchin, Joanne Tomlinson, Simona Lampariello, Tara Murray, Olivia Nugent, Samantha Reed, Christa Ronan, Salman Siddiqi

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