Allosteric interactions between the myristate- and ATP-site of the Abl kinase. by Roxana E Iacob, Jianming Zhang, Nathanael S Gray, John R Engen

Get full text

Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding by Julia R Kardon, Jamie A Moroco, John R Engen, Tania A Baker

Get full text

General structural features that regulate integrin affinity revealed by atypical αVβ8 by Jianchuan Wang, Yang Su, Roxana E. Iacob, John R. Engen, Timothy A. Springer

Get full text

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX by Daniel T. Cohen, Thomas E. Wales, Matthew W. McHenry, John R. Engen, Loren D. Walensky

Get full text

Native Capillary Electrophoresis–Mass Spectrometry of Near 1 MDa Non‐Covalent GroEL/GroES/Substrate Protein Complexes by Anne‐Lise Marie, Florian Georgescauld, Kendall R. Johnson, Somak Ray, John R. Engen, Alexander R. Ivanov

Get full text

Differential impact of BTK active site inhibitors on the conformational state of full-length BTK by Raji E Joseph, Neha Amatya, D Bruce Fulton, John R Engen, Thomas E Wales, Amy Andreotti

Get full text

The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core by Noah B. Bloch, Thomas E. Wales, Michelle S. Prew, Hannah R. Levy, John R. Engen, Loren D. Walensky

Get full text

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states by David Yin-wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti

Get full text

Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker by Klaus Bonazza, Roxana E Iacob, Nathan E Hudson, Jing Li, Chafen Lu, John R Engen, Timothy A Springer

Get full text

Differential sensitivity of Src-family kinases to activation by SH3 domain displacement. by Jamie A Moroco, Jodi K Craigo, Roxana E Iacob, Thomas E Wales, John R Engen, Thomas E Smithgall

Get full text

Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases. by Nikita Chopra, Thomas E Wales, Raji E Joseph, Scott E Boyken, John R Engen, Robert L Jernigan, Amy H Andreotti

Get full text

Fusion surface structure, function, and dynamics of gamete fusogen HAP2 by Juan Feng, Xianchi Dong, Jennifer Pinello, Jun Zhang, Chafen Lu, Roxana E Iacob, John R Engen, William J Snell, Timothy A Springer

Get full text

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia by Raji E Joseph, Thomas E Wales, Sandrine Jayne, Robert G Britton, D Bruce Fulton, John R Engen, Martin JS Dyer, Amy H Andreotti

Get full text

Structural mechanism of a drug-binding process involving a large conformational change of the protein target by Pelin Ayaz, Agatha Lyczek, YiTing Paung, Victoria R. Mingione, Roxana E. Iacob, Parker W. de Waal, John R. Engen, Markus A. Seeliger, Yibing Shan, David E. Shaw

Get full text

Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency by Michelle S. Prew, Christina M. Camara, Thomas Botzanowski, Jamie A. Moroco, Noah B. Bloch, Hannah R. Levy, Hyuk-Soo Seo, Sirano Dhe-Paganon, Gregory H. Bird, Henry D. Herce, Micah A. Gygi, Silvia Escudero, Thomas E. Wales, John R. Engen, Loren D. Walensky

Get full text

Allosteric control of Ubp6 and the proteasome via a bidirectional switch by Ka Ying Sharon Hung, Sven Klumpe, Markus R. Eisele, Suzanne Elsasser, Geng Tian, Shuangwu Sun, Jamie A. Moroco, Tat Cheung Cheng, Tapan Joshi, Timo Seibel, Duco Van Dalen, Xin-Hua Feng, Ying Lu, Huib Ovaa, John R. Engen, Byung-Hoon Lee, Till Rudack, Eri Sakata, Daniel Finley

Get full text

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6 by Nina Kerres, Steffen Steurer, Stefanie Schlager, Gerd Bader, Helmut Berger, Maureen Caligiuri, Christian Dank, John R. Engen, Peter Ettmayer, Bernhard Fischerauer, Gerlinde Flotzinger, Daniel Gerlach, Thomas Gerstberger, Teresa Gmaschitz, Peter Greb, Bingsong Han, Elizabeth Heyes, Roxana E. Iacob, Dirk Kessler, Heike Kölle, Lyne Lamarre, David R. Lancia, Simon Lucas, Moriz Mayer, Katharina Mayr, Nikolai Mischerikow, Katja Mück, Christoph Peinsipp, Oliver Petermann, Ulrich Reiser, Dorothea Rudolph, Klaus Rumpel, Carina Salomon, Dirk Scharn, Renate Schnitzer, Andreas Schrenk, Norbert Schweifer, Diane Thompson, Elisabeth Traxler, Roland Varecka, Tilman Voss, Alexander Weiss-Puxbaum, Sandra Winkler, Xiaozhang Zheng, Andreas Zoephel, Norbert Kraut, Darryl McConnell, Mark Pearson, Manfred Koegl

Get full text