John R. Mascola

John R. Mascola, M.D. John R. Mascola is an American physician-scientist, immunologist and infectious disease specialist. He was the director of the Vaccine Research Center (VRC), part of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH).  He also served as a principal advisor to Anthony Fauci, director of NIAID, on vaccines and biomedical research affairs. Mascola is the current Chief Scientific Officer for ModeX Therapeutics.

An internationally recognized expert on vaccine and antibody-based product development, Mascola has led biomedical research efforts targeting a wide breadth of viral pathogens for more than 30 years.

As part of the United States Government COVID-19 Response, Mascola led the Vaccine Development Team (VDT) of Operation Warp Speed facilitating the rapid development, evaluation, and subsequent authorization of effective COVID-19 vaccines. Provided by Wikipedia
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  1. 1
    Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection.

    Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection. by Zizhang Sheng, Chaim A Schramm, Mark Connors, Lynn Morris, John R Mascola, Peter D Kwong, Lawrence Shapiro

    Published 2016-05-01
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  2. 2
    Anti-HIV-1 response elicited in rabbits by anti-idiotype monoclonal antibodies mimicking the CD4-binding site.

    Anti-HIV-1 response elicited in rabbits by anti-idiotype monoclonal antibodies mimicking the CD4-binding site. by Roberto Burioni, Nicasio Mancini, Donata De Marco, Nicola Clementi, Mario Perotti, Giovanni Nitti, Monica Sassi, Filippo Canducci, Krisha Shvela, Patrizia Bagnarelli, John R Mascola, Massimo Clementi

    Published 2008-01-01
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  3. 3
    Virus-Like Particle Based Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide

    Virus-Like Particle Based Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide by Alemu Tekewe Mogus, Lihong Liu, Manxue Jia, Diane T. Ajayi, Kai Xu, Rui Kong, Jing Huang, Jian Yu, Peter D. Kwong, John R. Mascola, David D. Ho, Moriya Tsuji, Bryce Chackerian

    Published 2020-12-01
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  4. 4
    N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function.

    N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function. by Marie Pancera, Yongping Yang, Mark K Louder, Jason Gorman, Gabriel Lu, Jason S McLellan, Jonathan Stuckey, Jiang Zhu, Dennis R Burton, Wayne C Koff, John R Mascola, Peter D Kwong

    Published 2013-01-01
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  5. 5
    Longitudinal dynamics of the HIV-specific B cell response during intermittent treatment of primary HIV infection.

    Longitudinal dynamics of the HIV-specific B cell response during intermittent treatment of primary HIV infection. by Godelieve J de Bree, Adam K Wheatley, Rebecca M Lynch, Madhu Prabhakaran, Marlous L Grijsen, Jan M Prins, Stephen D Schmidt, Richard A Koup, John R Mascola, Adrian B McDermott

    Published 2017-01-01
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  6. 6
    B cell recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous primate CD4.

    B cell recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous primate CD4. by Mattias N E Forsell, Barna Dey, Andreas Mörner, Krisha Svehla, Sijy O'dell, Carl-Magnus Högerkorp, Gerald Voss, Rigmor Thorstensson, George M Shaw, John R Mascola, Gunilla B Karlsson Hedestam, Richard T Wyatt

    Published 2008-10-01
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  7. 7
    Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV.

    Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV. by Adam S Dingens, Priyamvada Acharya, Hugh K Haddox, Reda Rawi, Kai Xu, Gwo-Yu Chuang, Hui Wei, Baoshan Zhang, John R Mascola, Bridget Carragher, Clinton S Potter, Julie Overbaugh, Peter D Kwong, Jesse D Bloom

    Published 2018-07-01
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  8. 8
    Anti-viral efficacy of a next-generation CD4-binding site bNAb in SHIV-infected animals in the absence of anti-drug antibody responses

    Anti-viral efficacy of a next-generation CD4-binding site bNAb in SHIV-infected animals in the absence of anti-drug antibody responses by Sarah E. Lovelace, Sabrina Helmold Hait, Eun Sung Yang, Madison L. Fox, Cuiping Liu, Misook Choe, Xuejun Chen, Elizabeth McCarthy, John-Paul Todd, Ruth A. Woodward, Richard A. Koup, John R. Mascola, Amarendra Pegu

    Published 2022-10-01
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  9. 9
    DNA vaccine delivered by a needle-free injection device improves potency of priming for antibody and CD8+ T-cell responses after rAd5 boost in a randomized clinical trial.

    DNA vaccine delivered by a needle-free injection device improves potency of priming for antibody and CD8+ T-cell responses after rAd5 boost in a randomized clinical trial. by Barney S Graham, Mary E Enama, Martha C Nason, Ingelise J Gordon, Sheila A Peel, Julie E Ledgerwood, Sarah A Plummer, John R Mascola, Robert T Bailer, Mario Roederer, Richard A Koup, Gary J Nabel, VRC 008 Study Team

    Published 2013-01-01
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  10. 10
    Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections.

    Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections. by Kshitij Wagh, Michael S Seaman, Marshall Zingg, Tomas Fitzsimons, Dan H Barouch, Dennis R Burton, Mark Connors, David D Ho, John R Mascola, Michel C Nussenzweig, Jeffrey Ravetch, Rajeev Gautam, Malcolm A Martin, David C Montefiori, Bette Korber

    Published 2018-03-01
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  11. 11
    Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.

    Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability. by Rosemarie D Mason, Hugh C Welles, Cameron Adams, Bimal K Chakrabarti, Jason Gorman, Tongqing Zhou, Richard Nguyen, Sijy O'Dell, Sabrina Lusvarghi, Carole A Bewley, Hui Li, George M Shaw, Zizhang Sheng, Lawrence Shapiro, Richard Wyatt, Peter D Kwong, John R Mascola, Mario Roederer

    Published 2016-05-01
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  12. 12
    Protection of calves by a prefusion-stabilized bovine RSV F vaccine

    Protection of calves by a prefusion-stabilized bovine RSV F vaccine by Baoshan Zhang, Lei Chen, Chiara Silacci, Michelle Thom, Jeffrey C. Boyington, Aliaksandr Druz, M. Gordon Joyce, Efrain Guzman, Wing- Pui Kong, Yen-Ting Lai, Guillaume B. E. Stewart-Jones, Yaroslav Tsybovsky, Yongping Yang, Tongqing Zhou, Ulrich Baxa, John R. Mascola, Davide Corti, Antonio Lanzavecchia, Geraldine Taylor, Peter D. Kwong

    Published 2017-03-01
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  13. 13
    Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain

    Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain by Young D. Kwon, Amarendra Pegu, Eun Sung Yang, Baoshan Zhang, Michael F. Bender, Mangaiarkarasi Asokan, Qingbo Liu, Krisha McKee, Bob C. Lin, Tracy Liu, Mark K. Louder, Reda Rawi, Mateo Reveiz, Andrew J. Schaub, Chen-Hsiang Shen, Nicole A. Doria-Rose, Paolo Lusso, John R. Mascola, Peter D. Kwong

    Published 2023-12-01
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  14. 14
    Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery

    Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery by Cuiping Liu, Lingshu Wang, Jonah S. Merriam, Wei Shi, Eun Sung Yang, Yi Zhang, Man Chen, Wing-Pui Kong, Cheng Cheng, Yaroslav Tsybovsky, Tyler Stephens, Raffaello Verardi, Kwanyee Leung, Cody Stein, Adam S. Olia, Darcy R. Harris, Misook Choe, Baoshan Zhang, Barney S. Graham, Peter D. Kwong, Richard A. Koup, Amarendra Pegu, John R. Mascola

    Published 2023-08-01
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  15. 15
    Enhanced and sustained biodistribution of HIV-1 neutralizing antibody VRC01LS in human genital and rectal mucosa

    Enhanced and sustained biodistribution of HIV-1 neutralizing antibody VRC01LS in human genital and rectal mucosa by Maria P. Lemos, Rena D. Astronomo, Yunda Huang, Sandeep Narpala, Madhu Prabhakaran, Philipp Mann, Carmen A. Paez, Yiwen Lu, Gregory J. Mize, Hayley Glantz, Katharine Westerberg, Hunter Colegrove, Kimberly S. Smythe, Minggang Lin, Robert H. Pierce, Julia Hutter, Ian Frank, John R. Mascola, Adrian B. McDermott, Linda-Gail Bekker, M. Juliana McElrath

    Published 2024-11-01
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  16. 16
    Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus.

    Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus. by Li Ou, Steven J Chen, I-Ting Teng, Lijuan Yang, Baoshan Zhang, Tongqing Zhou, Andrea Biju, Cheng Cheng, Wing-Pui Kong, Nicholas C Morano, Erik-Stephane D Stancofski, John-Paul Todd, Yaroslav Tsybovsky, Shuishu Wang, Cheng-Yan Zheng, John R Mascola, Lawrence Shapiro, Ruth A Woodward, Ursula J Buchholz, Peter D Kwong

    Published 2023-09-01
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  17. 17
    Enhancing Anti-SARS-CoV-2 Neutralizing Immunity by Genetic Delivery of Enveloped Virus-like Particles Displaying SARS-CoV-2 Spikes

    Enhancing Anti-SARS-CoV-2 Neutralizing Immunity by Genetic Delivery of Enveloped Virus-like Particles Displaying SARS-CoV-2 Spikes by Yongping Yang, Wing-Pui Kong, Cuiping Liu, Tracy J. Ruckwardt, Yaroslav Tsybovsky, Lingshu Wang, Shuishu Wang, Daniel W. Biner, Man Chen, Tracy Liu, Jonah Merriam, Adam S. Olia, Li Ou, Qi Qiu, Wei Shi, Tyler Stephens, Eun Sung Yang, Baoshan Zhang, Yi Zhang, Qiong Zhou, Reda Rawi, Richard A. Koup, John R. Mascola, Peter D. Kwong

    Published 2023-08-01
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  18. 18
    An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial

    An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial by Adam D. DeZure, Emily E. Coates, Zonghui Hu, Galina V. Yamshchikov, Kathryn L. Zephir, Mary E. Enama, Sarah H. Plummer, Ingelise J. Gordon, Florence Kaltovich, Sarah Andrews, Adrian McDermott, Michelle C. Crank, Richard A Koup, Richard M. Schwartz, Robert T. Bailer, Xiangjie Sun, John R. Mascola, Terrence M. Tumpey, Barney S. Graham, Julie E. Ledgerwood

    Published 2017-06-01
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  19. 19
    Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses

    Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses by Yongping Yang, Wei Shi, Olubukola M. Abiona, Alexandra Nazzari, Adam S. Olia, Li Ou, Emily Phung, Tyler Stephens, Yaroslav Tsybovsky, Raffaello Verardi, Shuishu Wang, Anne Werner, Christina Yap, David Ambrozak, Tatsiana Bylund, Tracy Liu, Richard Nguyen, Lingshu Wang, Baoshan Zhang, Tongqing Zhou, Gwo-Yu Chuang, Barney S. Graham, John R. Mascola, Kizzmekia S. Corbett, Peter D. Kwong

    Published 2021-01-01
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  20. 20
    Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria

    Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria by Joseph R. Francica, Wei Shi, Gwo-Yu Chuang, Steven J. Chen, Lais Da Silva Pereira, S. Katie Farney, Barbara J. Flynn, Li Ou, Tyler Stephens, Yaroslav Tsybovsky, Lawrence T. Wang, Alexander Anderson, Zoltan Beck, Marlon Dillon, Azza H. Idris, Nicholas Hurlburt, Tracy Liu, Baoshan Zhang, Carl R. Alving, Gary R. Matyas, Marie Pancera, John R. Mascola, Peter D. Kwong, Robert A. Seder

    Published 2021-03-01
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