Transgenic T-cell receptor immunotherapy for cancer: building on clinical success by Natasha Oppermans, Gray Kueberuwa, Robert E. Hawkins, John S. Bridgeman

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426 Anti-folate receptor alpha (FRα) CoStimulatory Antigen Receptor (CoStAR™) drives distinct cytokine-mediated proliferation responses in CD4+ and CD8+ T cells by Mark Dudley, Gray Kueberuwa, John S Bridgeman, Martina Sykorova, Robert E Hawkins

423 Single cell RNA sequencing reveals functionally validated signatures of cytotoxicity in anti-FRα CoStimulatory Antigen Receptor (CoStARTM) activated CD4+ T cells by Mark Dudley, Gray Kueberuwa, John S Bridgeman, Martina Sykorova, Leyuan Bao, Robert E Hawkins, Katrina Sherbina Baklan, Owen Moon, Jinzhou Yuan

177 Treatment outcomes with unselected autologous tumor infiltrating lymphocytes in patients with checkpoint inhibition–refractory advanced cutaneous melanoma by Natalia Kirillova, Robert Hawkins, Gray Kueberuwa, Paul C Lorigan, Yizhou Jiang, Fiona C Thistlethwaite, Manon Pillai, Martine Thomas, John S Bridgeman, Ryan D Guest, Zachary J Roberts

Signaling via a CD28/CD40 chimeric costimulatory antigen receptor (CoStAR™), targeting folate receptor alpha, enhances T cell activity and augments tumor reactivity of tumor infilt... by Milena Kalaitsidou, Owen R. Moon, Martina Sykorova, Leyuan Bao, Yun Qu, Sujita Sukumaran, Michael Valentine, Xingliang Zhou, Veethika Pandey, Kay Foos, Sergey Medvedev, Daniel J. Powell Jr, Akshata Udyavar, Eric Gschweng, Ruben Rodriguez, Mark E. Dudley, Robert E. Hawkins, Gray Kueberuwa, John S. Bridgeman

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Cellular-level versus receptor-level response threshold hierarchies in T-cell activation by Hugo Antonius van den Berg, Kristin eLadell, Kelly eMiners, Bruno eLaugel, Sian eLlewellyn-Lacey, Mathew eClement, David K Cole, Emma eGostick, Linda eWooldridge, Andrew Kelvin Sewell, John Stephen Bridgeman, David A Price, David A Price

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Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope by David K. Cole, Anna Fuller, Garry Dolton, Efthalia Zervoudi, Mateusz Legut, Kim Miles, Lori Blanchfield, Florian Madura, Christopher J. Holland, Anna M. Bulek, John S. Bridgeman, John J. Miles, John J. Miles, Andrea J. A. Schauenburg, Konrad Beck, Brian D. Evavold, Pierre J. Rizkallah, Andrew K. Sewell

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Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells by Frances E Pearson, Kirsteen M Tullett, Ingrid M Leal‐Rojas, Oscar L Haigh, Kelly‐Anne Masterman, Carina Walpole, John S Bridgeman, James E McLaren, Kristin Ladell, Kelly Miners, Sian Llewellyn‐Lacey, David A Price, Antje Tunger, Marc Schmitz, John J Miles, Mireille H Lahoud, Kristen J Radford

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