John S. Lazo

John Stephen Lazo is an American pharmacologist noted for his work discovering the fundamental mechanisms of action of small molecule therapeutics and the factors that confer drug resistance. He is a professor emeritus of pharmacology at University of Virginia. Provided by Wikipedia
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  1. 1
    The hubris and humility of cancer pharmacology in the post immuno‐oncology era

    The hubris and humility of cancer pharmacology in the post immuno‐oncology era by John S. Lazo

    Published 2019-12-01
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  2. 2
    Cutting down the time to identify challenging tumor therapeutic targets and drug combinations using synthetic lethal approaches [version 1; referees: 2 approved]

    Cutting down the time to identify challenging tumor therapeutic targets and drug combinations using synthetic lethal approaches [version 1; referees: 2 approved] by John S. Lazo

    Published 2018-03-01
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  3. 3
    An acute respiratory distress syndrome drug development collaboration stimulated by the Virginia Drug Discovery Consortium

    An acute respiratory distress syndrome drug development collaboration stimulated by the Virginia Drug Discovery Consortium by John S. Lazo, Ruben M.L. Colunga-Biancatelli, Pavel. A. Solopov, John D. Catravas

    Published 2023-09-01
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  4. 4
    Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice

    Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice by Julie M. Cramer, Mark W. Zimmerman, Tim Thompson, Gregg E. Homanics, John S. Lazo, Eric Lagasse

    Published 2014-07-01
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  5. 5
    High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons

    High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons by Elizabeth R. Sharlow, Danielle C. Llaneza, William E. Grever, Garnett A. Mingledorff, Anna J. Mendelson, George S. Bloom, John S. Lazo

    Published 2023-09-01
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  6. 6
    Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production

    Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production by Oscar Aguilar-Sopeña, Sara Hernández-Pérez, Sergio Alegre-Gómez, Patricia Castro-Sánchez, Alba Iglesias-Ceacero, John S. Lazo, Pedro Roda-Navarro

    Published 2020-04-01
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  7. 7
    Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators

    Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators by Joel S Greenberger, David eClump, Valerian eKagan, Hulya eBayir, John S Lazo, Peter eWipf, Song eLi, Xiang eGao, Michael Wayne Epperly

    Published 2012-01-01
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  8. 8
    Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity.

    Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. by Elizabeth R Sharlow, Gabriela Mustata Wilson, David Close, Stephanie Leimgruber, Manuj Tandon, Robyn B Reed, Tong Ying Shun, Q Jane Wang, Peter Wipf, John S Lazo

    Published 2011-01-01
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  9. 9
    Design, Synthesis, and Biological Evaluation of PKD Inhibitors

    Design, Synthesis, and Biological Evaluation of PKD Inhibitors by Marie-Céline Frantz, Karla Bravo-Altamirano, Courtney R. LaValle, Manuj Tandon, Stephanie Leimgruber, Elizabeth R. Sharlow, John S. Lazo, Q. Jane Wang, Peter Wipf, Kara M. George

    Published 2011-04-01
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  10. 10
    Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer

    Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer by John S. Lazo, Elizabeth R. Sharlow, Robert Cornelison, Duncan J. Hart, Danielle C. Llaneza, Anna J. Mendelson, Ettore J. Rastelli, Nikhil R. Tasker, Charles N. Landen, Peter Wipf

    Published 2021-06-01
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  11. 11
    Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z.

    Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z. by Sager J Gosai, Joon Hyeok Kwak, Cliff J Luke, Olivia S Long, Dale E King, Kevin J Kovatch, Paul A Johnston, Tong Ying Shun, John S Lazo, David H Perlmutter, Gary A Silverman, Stephen C Pak

    Published 2010-11-01
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