An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling [version 1; peer review: 2 approved] by Jiahuai Han, Jianfeng Wu, John Silke

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Future Therapeutic Directions for Smac-Mimetics by Emma Morrish, Gabriela Brumatti, John Silke

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Digesting the Role of JAK-STAT and Cytokine Signaling in Oral and Gastric Cancers by Yanhong Ni, Jun T. Low, Jun T. Low, John Silke, John Silke, Lorraine A. O’Reilly, Lorraine A. O’Reilly

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The Immuno-Modulatory Effects of Inhibitor of Apoptosis Protein Antagonists in Cancer Immunotherapy by Jessica Michie, Conor J. Kearney, Edwin D. Hawkins, John Silke, Jane Oliaro

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Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo by Emma Morrish, Liana Mackiewicz, Natasha Silke, Marc Pellegrini, John Silke, Gabriela Brumatti, Gregor Ebert

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Deletion of Gpatch2 does not alter Tnf expression in mice by Destiny Dalseno, Holly Anderton, Andrew Kueh, Marco J Herold, John Silke, Andreas Strasser, Philippe Bouillet

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Effect of Immunosuppressive Agents on Hepatocyte Apoptosis Post-Liver Transplantation. by Eu Jin Lim, Ruth Chin, Ueli Nachbur, John Silke, Zhiyuan Jia, Peter W Angus, Joseph Torresi

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Determination of Pseudokinase-ligand Interaction by a Fluorescence-based Thermal Shift Assay by Isabelle Lucet, Joanne Hildebrand, Peter Czabotar, Jian-Guo Zhang, Nicos Nicola, John Silke, Jeffrey Babon, James Murphy

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IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans by Che A. Stafford, Kate E. Lawlor, Valentin J. Heim, Aleksandra Bankovacki, Jonathan P. Bernardini, John Silke, Ueli Nachbur

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The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family by Xiangyi S. Wang, Thomas R. Cotton, Sarah J. Trevelyan, Lachlan W. Richardson, Wei Ting Lee, John Silke, Bernhard C. Lechtenberg

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High molecular weight hyaluronic acid drastically reduces chemotherapy-induced mucositis and apoptotic cell death by Ali I. Mohammed, Antonio Celentano, Rita Paolini, Jun T. Low, John Silke, Lorraine A. O’ Reilly, Michael McCullough, Nicola Cirillo

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Convolutional neural networks for accurate real-time diagnosis of oral epithelial dysplasia and oral squamous cell carcinoma using high-resolution in vivo confocal microscopy by Rishi S. Ramani, Ivy Tan, Lindsay Bussau, Lorraine A. O’Reilly, John Silke, Christopher Angel, Antonio Celentano, Lachlan Whitehead, Michael McCullough, Tami Yap

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The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis by Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James M. Murphy, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Warren S. Alexander, Emma C. Josefsson

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HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death by Nieves Peltzer, Eva Rieser, Lucia Taraborrelli, Peter Draber, Maurice Darding, Barbara Pernaute, Yutaka Shimizu, Aida Sarr, Helena Draberova, Antonella Montinaro, Juan Pedro Martinez-Barbera, John Silke, Tristan A. Rodriguez, Henning Walczak

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OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling by Liang Ding, Yong Fu, Nisha Zhu, Mengxiang Zhao, Zhuang Ding, Xiaoxin Zhang, Yuxian Song, Yue Jing, Qian Zhang, Sheng Chen, Xiaofeng Huang, Lorraine A O’Reilly, John Silke, Qingang Hu, Yanhong Ni

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TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL. by Josep Maria Lluis, Ulrich Nachbur, Wendy Diane Cook, Ian Edward Gentle, Donia Moujalled, Maryline Moulin, Wendy Wei-Lynn Wong, Nufail Khan, Diep Chau, Bernard Andrew Callus, James Edward Vince, John Silke, David Lawrence Vaux

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Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs by Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, Ryodai Shindo, Joanne M. Hildebrand, Ryosuke Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, Satomi Adachi-Akahane, Sotaro Uemura, John Silke, Hideo Yagita, Masayuki Miura, Hiroyasu Nakano

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Correction: TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-κB Dependent Induction of cFLIPL. by Josep Maria Lluis, Ulrich Nachbur, Wendy Diane Cook, Ian Edward Gentle, Donia Moujalled, Maryline Moulin, Wendy Wei-Lynn Wong, Nufail Khan, Diep Chau, Bernard Andrew Callus, James Edward Vince, John Silke, David Lawrence Vaux

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Transplantable programmed death ligand 1 expressing gastroids from gastric cancer prone Nfkb1 −/− mice by Jun T. Low, Gwo-Yaw Ho, Mark Scott, Chin Wee Tan, Lachlan Whitehead, Kathy Barber, Hon Y. K. Yip, Johanna F. Dekkers, Yumiko Hirokawa, John Silke, Antony W. Burgess, Andreas Strasser, Tracy L. Putoczki, Lorraine A. O’Reilly

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Complex IIa formation and ABC transporters determine sensitivity of OSCC to Smac mimetics by Yuhan Wang, Zijian Liu, Qian Si, Wanqiu Lu, Yuxian Song, Wanyong Jin, Xihu Yang, Zihui Li, Xinyang Hu, Liang Ding, Yue Jing, Pei Weng, Qiuya Yu, Lorraine A. O’Reilly, John Silke, Xiaoxin Zhang, Qingang Hu, Yanhong Ni

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