Editorial: Mechanisms and strategies of unconventional antibody diversification for greater immune adaptability by Jordan D. Dimitrov, Waithaka Mwangi, Xiaotian Zhong

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Polyreactivity of antibodies from different B-cell subpopulations is determined by distinct sequence patterns of variable region by Maxime Lecerf, Robin V. Lacombe, Jordan D. Dimitrov

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Functional Changes of Therapeutic Antibodies upon Exposure to Pro-Oxidative Agents by Maxime Lecerf, Robin Lacombe, Alexia Kanyavuz, Jordan D. Dimitrov

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"Rational vaccine design" for HIV should take into account the adaptive potential of polyreactive antibodies. by Jordan D Dimitrov, Michel D Kazatchkine, Srinivas V Kaveri, Sebastien Lacroix-Desmazes

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Impact of Antigen Density on the Binding Mechanism of IgG Antibodies by Maya Hadzhieva, Anastas D. Pashov, Srinivas Kaveri, Sébastien Lacroix-Desmazes, Hugo Mouquet, Jordan D. Dimitrov

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Aromatic Guanylhydrazones for the Control of Heme-Induced Antibody Polyreactivity by Nina Božinović, Vladimir Ajdačić, Jelena Lazic, Maxime Lecerf, Victoria Daventure, Jasmina Nikodinovic-Runic, Igor M. Opsenica, Jordan D. Dimitrov

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Oxidized hemoglobin triggers polyreactivity and autoreactivity of human IgG via transfer of heme by Cyril Planchais, Remi Noe, Marie Gilbert, Maxime Lecerf, Srini V. Kaveri, Sébastien Lacroix-Desmazes, Lubka T. Roumenina, Jordan D. Dimitrov

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Hyperoxidized Species of Heme Have a Potent Capacity to Induce Autoreactivity of Human IgG Antibodies by Marie Wiatr, Maya Hadzhieva, Maxime Lecerf, Rémi Noé, Sune Justesen, Sébastien Lacroix-Desmazes, Marie-Agnès Dragon-Durey, Jordan D. Dimitrov

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Relevance of the Materno-Fetal Interface for the Induction of Antigen-Specific Immune Tolerance by Angelina Mimoun, Sandrine Delignat, Ivan Peyron, Victoria Daventure, Maxime Lecerf, Jordan D. Dimitrov, Srinivas V. Kaveri, Jagadeesh Bayry, Sébastien Lacroix-Desmazes

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Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1 by Olivia May, Olivia May, Olivia May, Nicolas S. Merle, Nicolas S. Merle, Nicolas S. Merle, Anne Grunenwald, Anne Grunenwald, Anne Grunenwald, Viviane Gnemmi, Juliette Leon, Juliette Leon, Cloé Payet, Cloé Payet, Tania Robe-Rybkine, Tania Robe-Rybkine, Tania Robe-Rybkine, Romain Paule, Florian Delguste, Simon C. Satchell, Peter W. Mathieson, Marc Hazzan, Marc Hazzan, Eric Boulanger, Jordan D. Dimitrov, Jordan D. Dimitrov, Jordan D. Dimitrov, Veronique Fremeaux-Bacchi, Veronique Fremeaux-Bacchi, Marie Frimat, Marie Frimat, Lubka T. Roumenina, Lubka T. Roumenina, Lubka T. Roumenina

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HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria by Cyril Planchais, Luis M. Molinos-Albert, Pierre Rosenbaum, Thierry Hieu, Alexia Kanyavuz, Dominique Clermont, Thierry Prazuck, Laurent Lefrou, Jordan D. Dimitrov, Sophie Hüe, Laurent Hocqueloux, Hugo Mouquet

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Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity by Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Oliver Ohlenschläger, Jordan D. Dimitrov, Hugo Mouquet

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Characterization of Renal Injury and Inflammation in an Experimental Model of Intravascular Hemolysis by Nicolas S. Merle, Nicolas S. Merle, Nicolas S. Merle, Anne Grunenwald, Anne Grunenwald, Anne Grunenwald, Marie-Lucile Figueres, Marie-Lucile Figueres, Marie-Lucile Figueres, Sophie Chauvet, Sophie Chauvet, Sophie Chauvet, Sophie Chauvet, Marie Daugan, Marie Daugan, Marie Daugan, Samantha Knockaert, Samantha Knockaert, Samantha Knockaert, Tania Robe-Rybkine, Tania Robe-Rybkine, Tania Robe-Rybkine, Remi Noe, Remi Noe, Remi Noe, Olivia May, Olivia May, Olivia May, Marie Frimat, Marie Frimat, Nathan Brinkman, Thomas Gentinetta, Sylvia Miescher, Pascal Houillier, Pascal Houillier, Pascal Houillier, Veronique Legros, Florence Gonnet, Olivier P. Blanc-Brude, Olivier P. Blanc-Brude, Marion Rabant, Regis Daniel, Jordan D. Dimitrov, Jordan D. Dimitrov, Jordan D. Dimitrov, Lubka T. Roumenina, Lubka T. Roumenina, Lubka T. Roumenina

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HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells by Cyril Planchais, Ayrin Kök, Alexia Kanyavuz, Valérie Lorin, Timothée Bruel, Florence Guivel-Benhassine, Tim Rollenske, Julie Prigent, Thierry Hieu, Thierry Prazuck, Laurent Lefrou, Hedda Wardemann, Olivier Schwartz, Jordan D. Dimitrov, Laurent Hocqueloux, Hugo Mouquet

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Enhanced Pro-apoptotic Effects of Fe(II)-Modified IVIG on Human Neutrophils by Stefanie Graeter, Christoph Schneider, Daniëlle Verschoor, Sandro von Däniken, Frank Seibold, Nikhil Yawalkar, Peter Villiger, Jordan D. Dimitrov, David F. Smith, Richard D. Cummings, Richard D. Cummings, Hans-Uwe Simon, Hans-Uwe Simon, Tchavdar Vassilev, Tchavdar Vassilev, Stephan von Gunten

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Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation by Alexandra Gerogianni, Alexandra Gerogianni, Jordan D. Dimitrov, Alessandra Zarantonello, Victoria Poillerat, Satheesh Chonat, Satheesh Chonat, Kerstin Sandholm, Karin E. McAdam, Kristina N. Ekdahl, Kristina N. Ekdahl, Kristina N. Ekdahl, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Camilla Mohlin, Camilla Mohlin, Lubka T. Roumenina, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson

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