MDM2-Based Proteolysis-Targeting Chimeras (PROTACs): An Innovative Drug Strategy for Cancer Treatment by André T. S. Vicente, Jorge A. R. Salvador

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Recent advances in oridonin derivatives with anticancer activity by Pedro J. M. Sobral, Pedro J. M. Sobral, André T. S. Vicente, Jorge A. R. Salvador, Jorge A. R. Salvador

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Highlights in USP7 inhibitors for cancer treatment by Rita I. Oliveira, Rita I. Oliveira, Romina A. Guedes, Romina A. Guedes, Jorge A. R. Salvador, Jorge A. R. Salvador

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Bioactive Bismuth Compounds: Is Their Toxicity a Barrier to Therapeutic Use? by Ângela Gonçalves, Mariana Matias, Jorge A. R. Salvador, Samuel Silvestre

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Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives by Daniela P.S. Alho, Jorge A.R. Salvador, Marta Cascante, Silvia Marin

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Bismuth(III) Reagents in Steroid and Terpene Chemistry by Jorge A. R. Salvador, Rui M. A. Pinto, Samuel M. Silvestre

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Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling by Ana S. C. Valdeira, Ana S. C. Valdeira, Daniel A. Ritt, Deborah K. Morrison, James B. McMahon, Kirk R. Gustafson, Jorge A. R. Salvador, Jorge A. R. Salvador

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Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview by Romina A. Guedes, Patrícia Serra, Jorge A. R. Salvador, Rita C. Guedes

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Decoding the secrets: how conformational and structural regulators inhibit the human 20S proteasome by Pedro M. P. Fernandes, Pedro M. P. Fernandes, Pedro M. P. Fernandes, Romina A. Guedes, Romina A. Guedes, Romina A. Guedes, Bruno L. Victor, Jorge A. R. Salvador, Jorge A. R. Salvador, Rita C. Guedes

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Editorial: Head & Neck Cancer and Esophageal Cancer: From Biosignatures to Therapeutics by Victor C. Kok, Victor C. Kok, Cheng-Chia Yu, Cheng-Chia Yu, Jorge A.R. Salvador

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6β-Chloro-5α-hydroxy-20-oxopregnan-3β-yl acetate by Rui M. A. Pinto, Jorge A. R. Salvador, José A. Paixão, Ana Matos Beja, Manuela Ramos Silva

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Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach. by Salete J Baptista, Maria M C Silva, Elisabetta Moroni, Massimiliano Meli, Giorgio Colombo, Teresa C P Dinis, Jorge A R Salvador

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Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance by Carlota Leonardo-Sousa, Andreia Neves Carvalho, Romina A. Guedes, Pedro M. P. Fernandes, Natália Aniceto, Jorge A. R. Salvador, Maria João Gama, Rita C. Guedes

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Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors by Judite R. M. Coimbra, Salete J. Baptista, Teresa C. P. Dinis, Maria M. C. Silva, Paula I. Moreira, Armanda E. Santos, Jorge A. R. Salvador

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Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment by Judite R. M. Coimbra, Judite R. M. Coimbra, Daniela F. F. Marques, Daniela F. F. Marques, Salete J. Baptista, Salete J. Baptista, Salete J. Baptista, Cláudia M. F. Pereira, Cláudia M. F. Pereira, Paula I. Moreira, Paula I. Moreira, Teresa C. P. Dinis, Teresa C. P. Dinis, Armanda E. Santos, Armanda E. Santos, Jorge A. R. Salvador, Jorge A. R. Salvador

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New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies by Romina A. Guedes, Jorge H. Grilo, Andreia N. Carvalho, Pedro M. P. Fernandes, Ana S. Ressurreição, Vanessa Brito, Adriana O. Santos, Samuel Silvestre, Eleonora Gallerani, Maria João Gama, Riccardo Gavioli, Jorge A. R. Salvador, Rita C. Guedes

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Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment by Luís Costa, Luis Graca, Rita C. Acúrcio, Sabina Pozzi, Barbara Carreira, Marta Pojo, Nuria Gómez-Cebrián, Sandra Casimiro, Adelaide Fernandes, Andreia Barateiro, Vitor Farricha, Joaquim Brito, Ana Paula Leandro, Jorge A R Salvador, Leonor Puchades-Carrasco, Ronit Satchi-Fainaro, Rita C. Guedes, Helena F. Florindo

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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7 by Michael Gütschow, Jean Jacques Vanden Eynde, Josef Jampilek, CongBao Kang, Arduino A. Mangoni, Paola Fossa, Rafik Karaman, Andrea Trabocchi, Peter J. H. Scott, Jóhannes Reynisson, Simona Rapposelli, Stefania Galdiero, Jean-Yves Winum, Chiara Brullo, Katalin Prokai-Tatrai, Arun K. Sharma, Matthieu Schapira, Yasu-Taka Azuma, Laura Cerchia, Mariana Spetea, Giangiacomo Torri, Simona Collina, Athina Geronikaki, Alfonso T. García-Sosa, M. Helena Vasconcelos, Maria Emília Sousa, Ivan Kosalec, Tiziano Tuccinardi, Iola F. Duarte, Jorge A. R. Salvador, Massimo Bertinaria, Maurizio Pellecchia, Jussara Amato, Giulio Rastelli, Paula A. C. Gomes, Rita C. Guedes, Jean-Marc Sabatier, Ana Estévez-Braun, Bruno Pagano, Stefano Mangani, Rino Ragno, George Kokotos, Margherita Brindisi, Florenci V. González, Fernanda Borges, Mariarosaria Miloso, Jarkko Rautio, Diego Muñoz-Torrero

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