Editorial: Sepsis: studying the immune system to highlight biomarkers for diagnosis, prognosis and personalized treatments by Juan C. Cutrin, José C. Alves-Filho, José C. Alves-Filho, Bernhard Ryffel

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Sensor Placement in an Irregular 3D Surface for Improving Localization Accuracy Using a Multi-Objective Memetic Algorithm by Paula A. Graça, José C. Alves, Bruno M. Ferreira

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Data on the mechanisms underlying succinate-induced aortic contraction by Natália A. Gonzaga, Janaina A. Simplicio, Letícia N. Leite, Gabriel T. Vale, José M. Carballido, José C. Alves-Filho, Carlos R. Tirapelli

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Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw. by Igor L Calil, Ana C Zarpelon, Ana T G Guerrero, Jose C Alves-Filho, Sergio H Ferreira, Fernando Q Cunha, Thiago M Cunha, Waldiceu A Verri

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A Novel Simulation Platform for Underwater Data Muling Communications Using Autonomous Underwater Vehicles by Filipe B. Teixeira, Bruno M. Ferreira, Nuno Moreira, Nuno Abreu, Murillo Villa, João P. Loureiro, Nuno A. Cruz, José C. Alves, Manuel Ricardo, Rui Campos

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Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury. by Cristiana C Garcia, Wynne Weston-Davies, Remo C Russo, Luciana P Tavares, Milene A Rachid, José C Alves-Filho, Alexandre V Machado, Bernhard Ryffel, Miles A Nunn, Mauro M Teixeira

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MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. by Fabiane Sônego, Fernanda V S Castanheira, Paula G Czaikoski, Alexandre Kanashiro, Fabricio O Souto, Rafael O França, Daniele C Nascimento, Andressa Freitas, Fernando Spiller, Larissa D Cunha, Dario S Zamboni, José C Alves-Filho, Fernando Q Cunha

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Budlein A, a Sesquiterpene Lactone From Viguiera robusta, Alleviates Pain and Inflammation in a Model of Acute Gout Arthritis in Mice by Victor Fattori, Ana C. Zarpelon, Larissa Staurengo-Ferrari, Sergio M. Borghi, Tiago H. Zaninelli, Fernando B. Da Costa, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Nilton S. Arakawa, Waldiceu A. Verri

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IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10 by Miriam M. Fonseca, Marcela Davoli-Ferreira, Marcela Davoli-Ferreira, Flávia Santa-Cecília, Rafaela M. Guimarães, Rafaela M. Guimarães, Francisco F. B. Oliveira, Ricardo Kusuda, David W. Ferreira, José C. Alves-Filho, Fernando Q. Cunha, Thiago M. Cunha

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Paradoxical roles of the neutrophil in sepsis: protective and deleterious by Fabiane eSônego, Fabiane eSônego, Fernanda Vargas e Silva Castanheira, Raphael Gomes Ferreira, Alexandre eKanashiro, Caio Abner Vitorino Golçalves Leite, Daniele Carvalho Nascimento, David Fernando Colón, Vanessa Fátima Borges, José C Alves-Filho, Fernando Queiróz Cunha

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Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice by Larissa Staurengo-Ferrari, Kenji W. Ruiz-Miyazawa, Felipe A. Pinho-Ribeiro, Victor Fattori, Tiago H. Zaninelli, Stephanie Badaro-Garcia, Sergio M. Borghi, Thacyana T. Carvalho, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri

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Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells by Jhimmy Talbot, Raphael S. Peres, Larissa G. Pinto, Rene D. R. Oliveira, Kalil A. Lima, Paula B. Donate, Jaqueline R. Silva, Bernard Ryffel, Thiago M. Cunha, José C. Alves-Filho, Foo Y. Liew, Paulo Louzada-Junior, Fernando de Queiroz Cunha

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Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice by Sergio M. Borghi, Victor Fattori, Felipe A. Pinho-Ribeiro, Talita P. Domiciano, Milena M. Miranda-Sapla, Tiago H. Zaninelli, Rubia Casagrande, Phileno Pinge-Filho, Wander R. Pavanelli, Jose C. Alves-Filho, Fernando Q. Cunha, Thiago M. Cunha, Waldiceu A. Verri

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Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling by Rafaela M Guimarães, Conceição E Aníbal-Silva, Marcela Davoli-Ferreira, Francisco Isaac F Gomes, Atlante Mendes, Maria CM Cavallini, Miriam M Fonseca, Samara Damasceno, Larissa P Andrade, Marco Colonna, Cyril Rivat, Fernando Q Cunha, José C Alves-Filho, Thiago M Cunha

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IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population by Daniele C. Nascimento, Paulo H. Melo, Annie R. Piñeros, Raphael G. Ferreira, David F. Colón, Paula B. Donate, Fernanda V. Castanheira, Aline Gozzi, Paula G. Czaikoski, Wanda Niedbala, Marcos C. Borges, Dario S. Zamboni, Foo Y. Liew, Fernando Q. Cunha, Jose C. Alves-Filho

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IL-22 Promotes IFN-γ-Mediated Immunity against <i>Histoplasma capsulatum</i> Infection by Morgana K.B. Prado, Caroline Fontanari, Camila O.S. Souza, Luiz G. Gardinassi, Karina F. Zoccal, Francisco W.G. de Paula-Silva, Ana P.F. Peti, Carlos A. Sorgi, Alyne F.G. Meirelles, Simone G. Ramos, José C. Alves-Filho, Lúcia H. Faccioli

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Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model by Flavio P. Veras, Giovanni F. Gomes, Bruna M. S. Silva, Diego B. Caetité, Cicero J. L. R. Almeida, Camila Meirelles S. Silva, Ayda H. Schneider, Emily S. Corneo, Caio S. Bonilha, Sabrina S. Batah, Ronaldo Martins, Eurico Arruda, Alexandre T. Fabro, José C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha

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Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis by Fernanda S. Soares, Flávia C. Amaral, Natália L. C. Silva, Matheus R. Valente, Lorena K. R. Santos, Lívia H. Yamashiro, Mara C. Scheffer, Fernanda V. E. S. Castanheira, Raphael G. Ferreira, Laura Gehrke, José C. Alves-Filho, Luciano P. Silva, Luciano P. Silva, André Báfica, André Báfica, Fernando Spiller, Fernando Spiller

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Molecular basis of carrageenan-induced cytokines production in macrophages by Alexandre H. Lopes, Rangel L. Silva, Miriam D. Fonseca, Francisco I. Gomes, Alexandre G. Maganin, Lucas S. Ribeiro, Lucas Maciel Mauriz Marques, Fernando Q. Cunha, Jose C. Alves-Filho, Dario S. Zamboni, Norberto P. Lopes, Bernardo S. Franklin, Aurélie Gombault, Fernando Silva Ramalho, Valerie F. J. Quesniaux, Isabelle Couillin, Bernhard Ryffel, Thiago M. Cunha

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Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis by David F. Colón, Carlos W. Wanderley, Marcelo Franchin, Camila M. Silva, Carlos H. Hiroki, Fernanda V. S. Castanheira, Paula B. Donate, Alexandre H. Lopes, Leila C. Volpon, Silvia K. Kavaguti, Vanessa F. Borges, Cesar A. Speck-Hernandez, Fernando Ramalho, Ana P. Carlotti, Fabio Carmona, Jose C. Alves-Filho, Foo Y. Liew, Fernando Q. Cunha

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