PI3K Signaling in Mechanisms and Treatments of Pulmonary Fibrosis Following Sepsis and Acute Lung Injury by Jean Piero Margaria, Lucia Moretta, Jose Carlos Alves-Filho, Emilio Hirsch

Get full text

Failure of neutrophil migration toward infectious focus in severe sepsis: a critical event for the outcome of this syndrome by José Carlos Alves-Filho, Claudia Benjamim, Beatriz Martins Tavares-Murta, Fernando Q Cunha

Get full text

Purinergic Cooperation Between P2Y2 and P2X7 Receptors Promote Cutaneous Leishmaniasis Control: Involvement of Pannexin-1 and Leukotrienes by Maria Luiza Thorstenberg, Marcos Vinícius Rangel Ferreira, Natália Amorim, Claudio Canetti, Fernanda B. Morrone, José Carlos Alves Filho, Robson Coutinho-Silva

Get full text

Nitric oxide favours tumour-promoting inflammation through mitochondria-dependent and -independent actions on macrophages by Daiana Drehmer, João Paulo Mesquita Luiz, Cesar Augusto Speck Hernandez, José Carlos Alves-Filho, Tracy Hussell, Paul Andrew Townsend, Salvador Moncada

Get full text

CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis. by Raphael Molinaro, Cyntia Pecli, Rafael F Guilherme, José Carlos Alves-Filho, Fernando Q Cunha, Claudio Canetti, Steven L Kunkel, Marcelo T Bozza, Claudia F Benjamim

Get full text

Blockage of Eosinopoiesis by IL-17A Is Prevented by Cytokine and Lipid Mediators of Allergic Inflammation by Pedro Xavier-Elsas, Bianca de Luca, Túlio Queto, Bruno Marques Vieira, Daniela Masid-de-Brito, Elizabeth Chen Dahab, José Carlos Alves Filho, Fernando Q. Cunha, Maria Ignez C. Gaspar-Elsas

Get full text

Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis. by Cristiano Xavier Lima, Danielle Gloria Souza, Flavio Almeida Amaral, Caio Tavares Fagundes, Irla Paula Stopa Rodrigues, Jose Carlos Alves-Filho, Marie Kosco-Vilbois, Walter Ferlin, Limin Shang, Greg Elson, Mauro Martins Teixeira

Get full text

Interleukin-10 rs2227307 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock by Cristina Padre Cardoso, Argenil José de Assis de Oliveira, Fernando Antônio Botoni, Isabela Cristina Porto Rezende, Jose Carlos Alves-Filho, Fernando de Queiroz Cunha, Juliana de Assis Silva Gomes Estanislau, Luiz Alexandre Viana Magno, Fabricio Rios-Santos

Get full text

The Role of ST2 Receptor in the Regulation of <i>Brucella abortus</i> Oral Infection by Raiany Santos, Priscila C. Campos, Marcella Rungue, Victor Rocha, David Santos, Viviani Mendes, Fabio V. Marinho, Flaviano Martins, Mayra F. Ricci, Diego C. dos Reis, Geovanni D. Cassali, José Carlos Alves-Filho, Angelica T. Vieira, Sergio C. Oliveira

Get full text

Acute Increase in O-GlcNAc Improves Survival in Mice With LPS-Induced Systemic Inflammatory Response Syndrome by Josiane Fernandes Silva, Vania C. Olivon, Fabiola Leslie A. C. Mestriner, Camila Ziliotto Zanotto, Raphael Gomes Ferreira, Nathanne Santos Ferreira, Carlos Alberto Aguiar Silva, João Paulo Mesquita Luiz, Juliano Vilela Alves, Rubens Fazan, Fernando Queiróz Cunha, Jose Carlos Alves-Filho, Rita C. Tostes

Get full text

Paradoxical interaction between cancer and long-term postsepsis disorder: impairment of de novo carcinogenesis versus favoring the growth of established tumors by Vladmir Claudio Cordeiro de Lima, Maria Dirlei Begnami, Carlos Wagner Wanderley, Roberto César Pereira Lima-Júnior, Fernando Queiroz Cunha, Vinicius Kannen, Caio Abner Leite, Jose Mauricio Mota, Kalil Alves de Lima, Leticia Almeida Nascimento, Marcela Davoli Ferreira, Camila Meirelles Souza Silva, David Fernando Colon, Juliana Yumi Sakita, Paula Ramos Viacava, Jose Carlos Alves-Filho, Ronaldo Albuquerque Ribeiro

Get full text

Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine by Juliana Escher Toller-Kawahisa, Paula Ramos Viacava, Eva Margareta Palsson-McDermott, Daniele Carvalho Nascimento, Mariana Patricia Cervantes-Silva, Shane Myles O'Carroll, Alessia Zotta, Luis Eduardo Alves Damasceno, Gabriel Azevedo Públio, Pedro Forti, João Paulo Mesquita Luiz, Bruno Marcel Silva de Melo, Timna Varela Martins, Vitor Marcel Faça, Annie Curtis, Thiago Mattar Cunha, Fernando de Queiroz Cunha, Luke Anthony John O'Neill, José Carlos Alves-Filho

Get full text

Tissue-specific metabolic profile drives iNKT cell function during obesity and liver injury by Cristhiane Favero Aguiar, Felipe Corrêa-da-Silva, Michelangelo Bauwelz Gonzatti, Monara Kaelle Angelim, Marco Antonio Pretti, Gustavo Gastão Davanzo, Bianca Gazieri Castelucci, Lauar Brito Monteiro, Gisele Castro, João Victor Virgilio-da-Silva, Guilherme Ribeiro, Vitor Jaccomo, Mirella C. Pereira Andrade, Webster Leonardo Costa, Victor Gambarini, Fernanda Fernandes Terra, José Carlos Alves-Filho, Niels Olsen Saraiva Câmara, Mariana Boroni, Alexandre Castro Keller, Pedro M. Moraes-Vieira

Get full text

The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils by Juliana Escher Toller-Kawahisa, Carlos Hiroji Hiroki, Camila Meirelles de Souza Silva, Daniele Carvalho Nascimento, Gabriel Azevedo Públio, Timna Varela Martins, Luis Eduardo Alves Damasceno, Flávio Protásio Veras, Paula Ramos Viacava, Fábio Yuji Sukesada, Emily Anne Day, Alessia Zotta, Tristram Alexander Jasper Ryan, Rodrigo Moreira da Silva, Thiago Mattar Cunha, Norberto Peporine Lopes, Fernando de Queiroz Cunha, Luke Anthony John O’Neill, José Carlos Alves-Filho

Get full text

T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections by Igor Santiago-Carvalho, Gislane Almeida-Santos, Bruna Gois Macedo, Caio Cesar Barbosa-Bomfim, Fabricio Moreira Almeida, Marcos Vinícios Pinheiro Cione, Trupti Vardam-Kaur, Mia Masuda, Sarah Van Dijk, Bruno Marcel Melo, Rogério Silva do Nascimento, Rebeka da Conceição Souza, Alba Lucínia Peixoto-Rangel, Robson Coutinho-Silva, Mario Hiroyuki Hirata, José Carlos Alves-Filho, José Maria Álvarez, Elena Lassounskaia, Henrique Borges da Silva, Maria Regina D’Império-Lima

Get full text

Impact of Microbiota Depletion by Antibiotics on SARS-CoV-2 Infection of K18-hACE2 Mice by Patrícia Brito Rodrigues, Giovanni Freitas Gomes, Monara K. S. C. Angelim, Gabriela F. Souza, Stefanie Primon Muraro, Daniel A. Toledo-Teixeira, Bruna Amanda Cruz Rattis, Amanda Stephane Passos, Laís Passarielo Pral, Vinícius de Rezende Rodovalho, Arilson Bernardo dos Santos P. Gomes, Valquíria Aparecida Matheus, André Saraiva Leão Marcelo Antunes, Fernanda Crunfli, Krist Helen Antunes, Ana Paula Duarte de Souza, Sílvio Roberto Consonni, Luiz Osório Leiria, José Carlos Alves-Filho, Thiago M. Cunha, Pedro M. M. Moraes-Vieira, José Luiz Proença-Módena, Marco Aurélio R. Vinolo

Get full text