Cardiac regeneration: Options for repairing the injured heart by Jun Wang, Meilin An, Bernhard Johannes Haubner, Bernhard Johannes Haubner, Josef M. Penninger, Josef M. Penninger

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Incorporating Immune Cells into Organoid Models: Essential for Studying Human Disease by Ania Bogoslowski, Meilin An, Josef M. Penninger

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Redirecting Imipramine against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study by Lijo John, Caroline Vernersson, Hyesoo Kwon, Ulrich Elling, Josef M. Penninger, Ali Mirazimi

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Recalibrating vascular malformations and mechanotransduction by pharmacological intervention by Salim Abdelilah-Seyfried, M. Luisa Iruela-Arispe, Josef M. Penninger, Elisabeth Tournier-Lasserve, Miikka Vikkula, Ondine Cleaver

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Non-targeted N-glycome profiling reveals multiple layers of organ-specific diversity in mice by Johannes Helm, Stefan Mereiter, Tiago Oliveira, Anna Gattinger, David M. Markovitz, Josef M. Penninger, Friedrich Altmann, Johannes Stadlmann

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ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury. by Takafumi Minato, Tomokazu Yamaguchi, Midori Hoshizaki, Satoru Nirasawa, Jianbo An, Saori Takahashi, Josef M Penninger, Yumiko Imai, Keiji Kuba

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PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. by Bernhard J Haubner, G Gregory Neely, Jakob G J Voelkl, Federico Damilano, Keiji Kuba, Yumiko Imai, Vukoslav Komnenovic, Agnes Mayr, Otmar Pachinger, Emilio Hirsch, Josef M Penninger, Bernhard Metzler

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Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection by Vanessa Monteil, Matheus Dyczynski, Volker M Lauschke, Hyesoo Kwon, Gerald Wirnsberger, Sonia Youhanna, Haibo Zhang, Arthur S Slutsky, Carmen Hurtado del Pozo, Moritz Horn, Nuria Montserrat, Josef M Penninger, Ali Mirazimi

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Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells by Elena Garreta, Daniel Moya-Rull, Megan L. Stanifer, Vanessa Monteil, Patricia Prado, Andrés Marco, Carolina Tarantino, Maria Gallo, Gustav Jonsson, Astrid Hagelkruys, Ali Mirazimi, Steeve Boulant, Josef M. Penninger, Nuria Montserrat

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FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice by Barizah Malik, Iva Vokic, Thomas Mohr, Marle Poppelaars, Martin Holcmann, Philipp Novoszel, Gerald Timelthaler, Thomas Lendl, Dana Krauss, Ulrich Elling, Michael Mildner, Josef M Penninger, Peter Petzelbauer, Maria Sibilia, Agnes Csiszar

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Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells by Sofia Appelberg, Soham Gupta, Sara Svensson Akusjärvi, Anoop T. Ambikan, Flora Mikaeloff, Elisa Saccon, Ákos Végvári, Rui Benfeitas, Maike Sperk, Marie Ståhlberg, Shuba Krishnan, Kamal Singh, Josef M. Penninger, Ali Mirazimi, Ujjwal Neogi

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ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. by Hai-Yan Jin, Bei Song, Gavin Y Oudit, Sandra T Davidge, Hui-Min Yu, Yan-Yan Jiang, Ping-Jin Gao, Ding-Liang Zhu, Guang Ning, Zamaneh Kassiri, Josef M Penninger, Jiu-Chang Zhong

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Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome by Peter Tsvetkov, Marc L Mendillo, Jinghui Zhao, Jan E Carette, Parker H Merrill, Domagoj Cikes, Malini Varadarajan, Ferdy R van Diemen, Josef M Penninger, Alfred L Goldberg, Thijn R Brummelkamp, Sandro Santagata, Susan Lindquist

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Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression by Daniel Andergassen, Christoph P Dotter, Daniel Wenzel, Verena Sigl, Philipp C Bammer, Markus Muckenhuber, Daniela Mayer, Tomasz M Kulinski, Hans-Christian Theussl, Josef M Penninger, Christoph Bock, Denise P Barlow, Florian M Pauler, Quanah J Hudson

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Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor by Tümay Capraz, Nikolaus F Kienzl, Elisabeth Laurent, Jan W Perthold, Esther Föderl-Höbenreich, Clemens Grünwald-Gruber, Daniel Maresch, Vanessa Monteil, Janine Niederhöfer, Gerald Wirnsberger, Ali Mirazimi, Kurt Zatloukal, Lukas Mach, Josef M Penninger, Chris Oostenbrink, Johannes Stadlmann

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Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models by Ke Song, Xinyan Yang, Geng An, Xinyu Xia, Jiexiang Zhao, Xiaoheng Xu, Cong Wan, Tianyuan Liu, Yi Zheng, Shaofang Ren, Mei Wang, Gang Chang, Shane J. F. Cronin, Josef M. Penninger, Tao Jing, Xianghong Ou, Shuan Rao, Zhaoting Liu, Xiao-Yang Zhao

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Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level by Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F. Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M. Penninger, Gerhard Hummer, Peter Hinterdorfer

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Author Correction: Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level by Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F. Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M. Penninger, Gerhard Hummer, Peter Hinterdorfer

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A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors by Jasmin Taubenschmid‐Stowers, Michael Orthofer, Anna Laemmerer, Christian Krauditsch, Marianna Rózsová, Christian Studer, Daniela Lötsch, Johannes Gojo, Lisa Gabler, Matheus Dyczynski, Thomas Efferth, Astrid Hagelkruys, Georg Widhalm, Andreas Peyrl, Sabine Spiegl‐Kreinecker, Dominic Hoepfner, Shan Bian, Walter Berger, Juergen A Knoblich, Ulrich Elling, Moritz Horn, Josef M Penninger

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A microfluidic platform integrating functional vascularized organoids-on-chip by Clément Quintard, Emily Tubbs, Gustav Jonsson, Jie Jiao, Jun Wang, Nicolas Werschler, Camille Laporte, Amandine Pitaval, Thierno-Sidy Bah, Gideon Pomeranz, Caroline Bissardon, Joris Kaal, Alexandra Leopoldi, David A. Long, Pierre Blandin, Jean-Luc Achard, Christophe Battail, Astrid Hagelkruys, Fabrice Navarro, Yves Fouillet, Josef M. Penninger, Xavier Gidrol

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