1016 Enforcement of exhausted T cell epigenetic fate by HMG-box transcription factor TOX by Omar Khan, Sasikanth Manne, E John Wherry, Josephine R Giles, Amy E Baxter, Shin Foong Ngiow, Yinghui Jane Huang, Simone L Park, Jennifer E Wu

The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade by Susan E. McClory, Oishi Bardhan, Kelly S. Rome, Josephine R. Giles, Amy E. Baxter, Lanwei Xu, Phyllis A. Gimotty, Robert B. Faryabi, E. John Wherry, Warren S. Pear, Martha S. Jordan

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1522 Revitalizing systemic immune responses in progressive NSCLC using FLT3L and SBRT by Tibor Keler, Balazs Halmos, Divij Mathew, Chandan Guha, Jeffrey M Levsky, E John Wherry, Josephine R Giles, Nitin Ohri, Shin Foong Ngiow, KC Wumesh, Madhur Garg, Haiying Cheng, Rasim Gucalp, William Bodner, Rafi Kabarriti, Claudia Gutierrez-Chavez, Adel Zakharia, Shalom Kalnicki, Michael J Yellin

Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction by Caroline Diorio, Rawan Shraim, Laura A. Vella, Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Scott W. Canna, Sarah E. Henrickson, Kevin O. McNerney, Frances Balamuth, Chakkapong Burudpakdee, Jessica Lee, Tomas Leng, Alvin Farrel, Michele P. Lambert, Kathleen E. Sullivan, E. John Wherry, David T. Teachey, Hamid Bassiri, Edward M. Behrens

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Correction for Merenstein et al., “Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome” by Carter Merenstein, Guanxiang Liang, Samantha A. Whiteside, Ana G. Cobián-Güemes, Madeline S. Merlino, Louis J. Taylor, Abigail Glascock, Kyle Bittinger, Ceylan Tanes, Jevon Graham-Wooten, Layla A. Khatib, Ayannah S. Fitzgerald, Shantan Reddy, Amy E. Baxter, Josephine R. Giles, Derek A. Oldridge, Nuala J. Meyer, E. John Wherry, John E. McGinniss, Frederic D. Bushman, Ronald G. Collman

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Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome by Carter Merenstein, Guanxiang Liang, Samantha A. Whiteside, Ana G. Cobián-Güemes, Madeline S. Merlino, Louis J. Taylor, Abigail Glascock, Kyle Bittinger, Ceylan Tanes, Jevon Graham-Wooten, Layla A. Khatib, Ayannah S. Fitzgerald, Shantan Reddy, Amy E. Baxter, Josephine R. Giles, Derek A. Oldridge, Nuala J. Meyer, E. John Wherry, John E. McGinniss, Frederic D. Bushman, Ronald G. Collman

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579-C Reinvigoration of progenitor-exhausted CD8 T cells by anti-CTLA-4 contributes to the sustained activity of combination checkpoint blockade by Xiaowei Xu, Wei Xu, Alexander Huang, Jeffrey Weber, Andy Minn, Kevin Wang, Tara Mitchell, Sasikanth Manne, Divij Mathew, E John Wherry, Daniel Tenney, Paulina Coutifaris, David Brocks, Sabrina Solis, Nicholas Han, Evgeny Kiner, Chirag Sachar, Sangeeth George, Patrick Yan, Melanie W Kiner, Amy I Laughlin, Shawn Kothari, Josephine R Giles, Rheem Ghinnagow, Cecile Alanio, Ahron Flowers, Ravi K Amaravadi, Giorgos C Karakousis, Lynn M Schuchter, Marcus Buggert, Ramin S Herati

Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19 by Sokratis A. Apostolidis, Sokratis A. Apostolidis, Amrita Sarkar, Heather M. Giannini, Rishi R. Goel, Divij Mathew, Aae Suzuki, Amy E. Baxter, Amy E. Baxter, Allison R. Greenplate, Allison R. Greenplate, Cécile Alanio, Cécile Alanio, Cécile Alanio, Mohamed Abdel-Hakeem, Mohamed Abdel-Hakeem, Derek A. Oldridge, Derek A. Oldridge, Derek A. Oldridge, Josephine R. Giles, Josephine R. Giles, Josephine R. Giles, Jennifer E. Wu, Jennifer E. Wu, Jennifer E. Wu, Zeyu Chen, Zeyu Chen, Yinghui Jane Huang, Yinghui Jane Huang, Jonathan Belman, Jonathan Belman, Ajinkya Pattekar, Ajinkya Pattekar, Sasikanth Manne, Sasikanth Manne, Oliva Kuthuru, Oliva Kuthuru, Jeanette Dougherty, Jeanette Dougherty, Brittany Weiderhold, Ariel R. Weisman, Caroline A. G. Ittner, Sigrid Gouma, Debora Dunbar, Ian Frank, Alexander C. Huang, Alexander C. Huang, Alexander C. Huang, Laura A. Vella, Laura A. Vella, The UPenn COVID Processing Unit, John P. Reilly, Scott E. Hensley, Scott E. Hensley, Lubica Rauova, Lubica Rauova, Liang Zhao, Nuala J. Meyer, Mortimer Poncz, Mortimer Poncz, Charles S. Abrams, E. John Wherry, E. John Wherry, E. John Wherry, E. John Wherry, Sharon Adamski, Zahidul Alam, Mary M. Addison, Katelyn T. Byrne, Aditi Chandra, Hélène C. Descamps, Nicholas Han, Yaroslav Kaminskiy, Shane C. Kammerman, Justin Kim, Jacob T. Hamilton, Nune Markosyan, Julia Han Noll, Dalia K. Omran, Eric Perkey, Elizabeth M. Prager, Dana Pueschl, Austin Rennels, Jennifer B. Shah, Jake S. Shilan, Nils Wilhausen, Ashley N. Vanderbeck

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