Open questions: respiratory chain supercomplexes—why are they there and what do they do? by Judy Hirst

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Paracoccus denitrificans: a genetically tractable model system for studying respiratory complex I by Owen D. Jarman, Olivier Biner, John J. Wright, Judy Hirst

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Structure of the turnover-ready state of an ancestral respiratory complex I by Bozhidar S. Ivanov, Hannah R. Bridges, Owen D. Jarman, Judy Hirst

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Using a chimeric respiratory chain and EPR spectroscopy to determine the origin of semiquinone species previously assigned to mitochondrial complex I by John J. Wright, Justin G. Fedor, Judy Hirst, Maxie M. Roessler

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Mechanism of rotenone binding to respiratory complex I depends on ligand flexibility by Caroline S. Pereira, Murilo H. Teixeira, David A. Russell, Judy Hirst, Guilherme M. Arantes

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Deleting the IF1-like ζ subunit from Paracoccus denitrificans ATP synthase is not sufficient to activate ATP hydrolysis by Febin Varghese, James N. Blaza, Andrew J. Y. Jones, Owen D. Jarman, Judy Hirst

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Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster by Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst

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Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex. by Andrew E Maclean, Hannah R Bridges, Mariana F Silva, Shujing Ding, Jana Ovciarikova, Judy Hirst, Lilach Sheiner

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Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy by Injae Chung, John J. Wright, Hannah R. Bridges, Bozhidar S. Ivanov, Olivier Biner, Caroline S. Pereira, Guilherme M. Arantes, Judy Hirst

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Structural basis for a complex I mutation that blocks pathological ROS production by Zhan Yin, Nils Burger, Duvaraka Kula-Alwar, Dunja Aksentijević, Hannah R. Bridges, Hiran A. Prag, Daniel N. Grba, Carlo Viscomi, Andrew M. James, Amin Mottahedin, Thomas Krieg, Michael P. Murphy, Judy Hirst

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The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors by Rachel E. Hardy, Injae Chung, Yizhou Yu, Samantha H. Y. Loh, Nobuhiro Morone, Clement Soleilhavoup, Marco Travaglio, Riccardo Serreli, Lia Panman, Kelvin Cain, Judy Hirst, Luis M. Martins, Marion MacFarlane, Kenneth R. Pryde

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Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I by Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy EH Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst, Barrie Kellam, Anne E Willis

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Structure of inhibitor-bound mammalian complex I by Hannah R. Bridges, Justin G. Fedor, James N. Blaza, Andrea Di Luca, Alexander Jussupow, Owen D. Jarman, John J. Wright, Ahmed-Noor A. Agip, Ana P. Gamiz-Hernandez, Maxie M. Roessler, Ville R. I. Kaila, Judy Hirst

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Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis by Zijian Fang, Giuditta Corbizi Fattori, Thomas McKerrell, Rebecca H. Boucher, Aimee Jackson, Rachel S. Fletcher, Dorian Forte, Jose-Ezequiel Martin, Sonia Fox, James Roberts, Rachel Glover, Erica Harris, Hannah R. Bridges, Luigi Grassi, Alba Rodriguez-Meira, Adam J. Mead, Steven Knapper, Joanne Ewing, Nauman M. Butt, Manish Jain, Sebastian Francis, Fiona J. Clark, Jason Coppell, Mary F. McMullin, Frances Wadelin, Srinivasan Narayanan, Dragana Milojkovic, Mark W. Drummond, Mallika Sekhar, Hesham ElDaly, Judy Hirst, Maike Paramor, E. Joanna Baxter, Anna L. Godfrey, Claire N. Harrison, Simón Méndez-Ferrer

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