Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry by Kristina Zalevskaja, Kristina Zalevskaja, Jukka-Pekka Mecklin, Jukka-Pekka Mecklin, Toni T. Seppälä, Toni T. Seppälä

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Descriptive study on subjective experience of genetic testing with respect to relationship, family planning and psychosocial wellbeing among women with lynch syndrome by Mari Kalamo, Johanna Mäenpää, Toni Seppälä, Jukka-Pekka Mecklin, Kirsi Pylvänäinen, Synnöve Staff

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Circulating metabolome landscape in Lynch syndrome by Tiina A. Jokela, Jari E. Karppinen, Minta Kärkkäinen, Jukka-Pekka Mecklin, Simon Walker, Toni T. Seppälä, Eija K. Laakkonen

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Molecular Basis of Mismatch Repair Protein Deficiency in Tumors from Lynch Suspected Cases with Negative Germline Test Results by Alisa Olkinuora, Annette Gylling, Henrikki Almusa, Samuli Eldfors, Anna Lepistö, Jukka-Pekka Mecklin, Taina Tuulikki Nieminen, Päivi Peltomäki

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Testing for Lynch Syndrome in Endometrial Carcinoma: From Universal to Age-Selective <i>MLH1</i> Methylation Analysis by Annukka Pasanen, Mikko Loukovaara, Elina Kaikkonen, Alisa Olkinuora, Kirsi Pylvänäinen, Pia Alhopuro, Päivi Peltomäki, Jukka-Pekka Mecklin, Ralf Bützow

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Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions by Erkki-Ville Wirta, Säde Szeto, Ulrika Hänninen, Maarit Ahtiainen, Jan Böhm, Jukka-Pekka Mecklin, Lauri A. Aaltonen, Toni T. Seppälä

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Impact of Age and Comorbidity on Multimodal Management and Survival from Colorectal Cancer: A Population-Based Study by Ilmo Kellokumpu, Matti Kairaluoma, Jukka-Pekka Mecklin, Henrik Kellokumpu, Ville Väyrynen, Erkki-Ville Wirta, Eero Sihvo, Teijo Kuopio, Toni T. Seppälä

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Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer by Kyösti Tahkola, Maarit Ahtiainen, Jukka-Pekka Mecklin, Ilmo Kellokumpu, Johanna Laukkarinen, Markku Tammi, Raija Tammi, Juha P. Väyrynen, Jan Böhm

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Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome by Tero Sievänen, Timo Törmäkangas, Eija K. Laakkonen, Jukka-Pekka Mecklin, Kirsi Pylvänäinen, Toni T. Seppälä, Päivi Peltomäki, Sarianna Sipilä, Elina Sillanpää

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Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases by Maarit Ahtiainen, Hanna Elomaa, Juha P. Väyrynen, Erkki-Ville Wirta, Teijo Kuopio, Olli Helminen, Toni T. Seppälä, Ilmo Kellokumpu, Jukka-Pekka Mecklin

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Immunoprofiles and DNA Methylation of Inflammatory Marker Genes in Ulcerative Colitis-Associated Colorectal Tumorigenesis by Satu Mäki-Nevala, Sanjeevi Ukwattage, Erkki-Ville Wirta, Maarit Ahtiainen, Ari Ristimäki, Toni T. Seppälä, Anna Lepistö, Jukka-Pekka Mecklin, Päivi Peltomäki

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A comparative pan-genome perspective of niche-adaptable cell-surface protein phenotypes in Lactobacillus rhamnosus. by Ravi Kant, Johanna Rintahaka, Xia Yu, Pia Sigvart-Mattila, Lars Paulin, Jukka-Pekka Mecklin, Maria Saarela, Airi Palva, Ingemar von Ossowski

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DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expressionResearch in context by Satu Mäki-Nevala, Satu Valo, Ari Ristimäki, Virinder Sarhadi, Sakari Knuutila, Minna Nyström, Laura Renkonen-Sinisalo, Anna Lepistö, Jukka-Pekka Mecklin, Päivi Peltomäki

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CD3⁺ and CD8⁺ T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer by Topias Karjula, Hanna Elomaa, Anne Niskakangas, Olli Mustonen, Iiris Puro, Teijo Kuopio, Maarit Ahtiainen, Jukka-Pekka Mecklin, Toni T. Seppälä, Erkki-Ville Wirta, Eero Sihvo, Juha P. Väyrynen, Fredrik Yannopoulos, Olli Helminen

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Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesisResearch in context by Marjaana Pussila, Aleksi Laiho, Petri Törönen, Pauliina Björkbacka, Sonja Nykänen, Kirsi Pylvänäinen, Liisa Holm, Jukka-Pekka Mecklin, Laura Renkonen-Sinisalo, Taru Lehtonen, Anna Lepistö, Jere Linden, Satu Mäki-Nevala, Päivi Peltomäki, Minna Nyström

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Distinct Mutational Profile of Lynch Syndrome Colorectal Cancers Diagnosed under Regular Colonoscopy Surveillance by Aysel Ahadova, Pauline Luise Pfuderer, Maarit Ahtiainen, Alexej Ballhausen, Lena Bohaumilitzky, Svenja Kösegi, Nico Müller, Yee Lin Tang, Kosima Kosmalla, Johannes Witt, Volker Endris, Albrecht Stenzinger, Magnus von Knebel Doeberitz, Hendrik Bläker, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Toni T. Seppälä, Matthias Kloor

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Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival by Tatiana Cajuso, Päivi Sulo, Tomas Tanskanen, Riku Katainen, Aurora Taira, Ulrika A. Hänninen, Johanna Kondelin, Linda Forsström, Niko Välimäki, Mervi Aavikko, Eevi Kaasinen, Ari Ristimäki, Selja Koskensalo, Anna Lepistö, Laura Renkonen-Sinisalo, Toni Seppälä, Teijo Kuopio, Jan Böhm, Jukka-Pekka Mecklin, Outi Kilpivaara, Esa Pitkänen, Kimmo Palin, Lauri A. Aaltonen

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The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution by Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, Saskia Haupt, Elisabeth Pfaffendorf, Florian Seidler, Johannes Witt, Alejandro Hernandez Sanchez, Katharina Urban, Markus Draxlbauer, Sonja Krausert, Aysel Ahadova, Martin Simon Kalteis, Pauline L. Pfuderer, Daniel Heid, Damian Stichel, Johannes Gebert, Maria Bonsack, Sarah Schott, Hendrik Bläker, Toni Seppälä, Jukka-Pekka Mecklin, Sanne Ten Broeke, Maartje Nielsen, Vincent Heuveline, Julia Krzykalla, Axel Benner, Angelika Beate Riemer, Magnus von Knebel Doeberitz, Matthias Kloor

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Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer by Johanna Kondelin, Kari Salokas, Lilli Saarinen, Kristian Ovaska, Heli Rauanheimo, Roosa‐Maria Plaketti, Jiri Hamberg, Xiaonan Liu, Leena Yadav, Alexandra E Gylfe, Tatiana Cajuso, Ulrika A Hänninen, Kimmo Palin, Heikki Ristolainen, Riku Katainen, Eevi Kaasinen, Tomas Tanskanen, Mervi Aavikko, Minna Taipale, Jussi Taipale, Laura Renkonen‐Sinisalo, Anna Lepistö, Selja Koskensalo, Jan Böhm, Jukka‐Pekka Mecklin, Halit Ongen, Emmanouil T Dermitzakis, Outi Kilpivaara, Pia Vahteristo, Mikko Turunen, Sampsa Hautaniemi, Sari Tuupanen, Auli Karhu, Niko Välimäki, Markku Varjosalo, Esa Pitkänen, Lauri A Aaltonen

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Contribution of allelic imbalance to colorectal cancer by Kimmo Palin, Esa Pitkänen, Mikko Turunen, Biswajyoti Sahu, Päivi Pihlajamaa, Teemu Kivioja, Eevi Kaasinen, Niko Välimäki, Ulrika A. Hänninen, Tatiana Cajuso, Mervi Aavikko, Sari Tuupanen, Outi Kilpivaara, Linda van den Berg, Johanna Kondelin, Tomas Tanskanen, Riku Katainen, Marta Grau, Heli Rauanheimo, Roosa-Maria Plaketti, Aurora Taira, Päivi Sulo, Tuomo Hartonen, Kashyap Dave, Bernhard Schmierer, Sandeep Botla, Maria Sokolova, Anna Vähärautio, Kornelia Gladysz, Halit Ongen, Emmanouil Dermitzakis, Jesper Bertram Bramsen, Torben Falck Ørntoft, Claus Lindbjerg Andersen, Ari Ristimäki, Anna Lepistö, Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, Jussi Taipale, Lauri A. Aaltonen

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