T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology by Guillermo Rodríguez-Hernández, Sanil Bhatia, Carolina Vicente-Dueñas, Arndt Borkhardt, Julia Hauer, Isidro Sánchez-García

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YB-1-based oncolytic virotherapy in combination with CD47 blockade enhances phagocytosis of pediatric sarcoma cells by Anna Josefine von Ofen, Uwe Thiel, Jennifer Eck, Hendrik Gassmann, Melanie Thiede, Julia Hauer, Per Sonne Holm, Per Sonne Holm, Sebastian J. Schober

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Potential role of STAG1 mutations in genetic predisposition to childhood hematological malignancies by Claudia Saitta, Stefano Rebellato, Laura Rachele Bettini, Giovanni Giudici, Nicolò Panini, Eugenio Erba, Valentina Massa, Franziska Auer, Ulrike Friedrich, Julia Hauer, Andrea Biondi, Grazia Fazio, Giovanni Cazzaniga

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T Cells Directed against the Metastatic Driver Chondromodulin-1 in Ewing Sarcoma: Comparative Engineering with CRISPR/Cas9 vs. Retroviral Gene Transfer for Adoptive Transfer by Busheng Xue, Kristina von Heyking, Hendrik Gassmann, Mansour Poorebrahim, Melanie Thiede, Kilian Schober, Josef Mautner, Julia Hauer, Jürgen Ruland, Dirk H. Busch, Uwe Thiel, Stefan E. G. Burdach

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Correlation of Transcriptomics and FDG-PET SUVmax Indicates Reciprocal Expression of Stemness-Related Transcription Factor and Neuropeptide Signaling Pathways in Glucose Metabolism... by Carolin Prexler, Marie Sophie Knape, Janina Erlewein-Schweizer, Wolfgang Roll, Katja Specht, Klaus Woertler, Wilko Weichert, Irene von Luettichau, Claudia Rossig, Julia Hauer, Guenther H. S. Richter, Wolfgang Weber, Stefan Burdach

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A rare PALB2 germline variant causing G2/M cell cycle arrest is associated with isolated myelosarcoma in infancy by Angelina Beer, Ricardo Beck, Anne Schedel, Malte vonBonin, Jörn Meinel, Ulrike Anne Friedrich, Maria Menzel, Meinolf Suttorp, Sebastian Brenner, Guido Fitze, Björn Lange, Ralf Knöfler, Julia Hauer, Franziska Auer

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TCR-transgenic T cells and YB-1-based oncolytic virotherapy improve survival in a preclinical Ewing sarcoma xenograft mouse model by Sebastian J. Schober, Melanie Thiede, Hendrik Gassmann, Anna Josefine von Ofen, Pia Knoch, Jennifer Eck, Carolin Prexler, Corazon Kordass-Wally, Julia Hauer, Stefan Burdach, Stefan Burdach, Per Sonne Holm, Per Sonne Holm, Uwe Thiel

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Cancer Stem Cells in Pheochromocytoma and Paraganglioma by Laura D. Scriba, Stefan R. Bornstein, Stefan R. Bornstein, Alice Santambrogio, Alice Santambrogio, Gregor Mueller, Angela Huebner, Julia Hauer, Andreas Schedl, Ben Wielockx, Graeme Eisenhofer, Graeme Eisenhofer, Cynthia L. Andoniadou, Cynthia L. Andoniadou, Charlotte Steenblock

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Germline POT1 Deregulation Can Predispose to Myeloid Malignancies in Childhood by Pia Michler, Anne Schedel, Martha Witschas, Ulrike Anne Friedrich, Rabea Wagener, Juha Mehtonen, Triantafyllia Brozou, Maria Menzel, Carolin Walter, Dalileh Nabi, Glen Pearce, Miriam Erlacher, Gudrun Göhring, Martin Dugas, Merja Heinäniemi, Arndt Borkhardt, Friedrich Stölzel, Julia Hauer, Franziska Auer

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Hyperdiploid acute lymphoblastic leukemia in children with LZTR1 germline variants by Lisa Zipper, Rabea Wagener, Ute Fischer, Anna Hoffmann, Layal Yasin, Danielle Brandes, Stavrieta Soura, Ammarah Anwar, Carolin Walter, Julian Varghese, Julia Hauer, Franziska Auer, Sanil Bhatia, Martin Dugas, Stefanie V. Junk, Martin Stanulla, Oskar A. Haas, Arndt Borkhardt, Tobias Reiff, Triantafyllia Brozou

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Cytokine Hyperresponsiveness in Children With ETV6::RUNX1-positive Acute Lymphoblastic Leukemia After Challenge With Common Pathogens by Nadine Rüchel, Marina Oldenburg, Stefan Janssen, Aleksandra A. Pandyra, Wei Liu, Eleni Vasileiou, Daniel Hein, Vera Helena Jepsen, Ute Fischer, Daniel Picard, Gesine Kögler, Julia Hauer, Franziska Auer, Angelina Beer, Ortwin Adams, Colin MacKenzie, Martin Jaeger, Mihai G. Netea, Arndt Borkhardt, Katharina L. Gössling

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No Improvement of Survival for Alveolar Rhabdomyosarcoma Patients After HLA-Matched Versus -Mismatched Allogeneic Hematopoietic Stem Cell Transplantation Compared to Standard-of-Ca... by Sebastian Johannes Schober, Erika Hallmen, Florian Reßle, Hendrik Gassmann, Carolin Prexler, Angela Wawer, Irene von Luettichau, Ruth Ladenstein, Bernarda Kazanowska, Gustaf Ljungman, Felix Niggli, Olli Lohi, Julia Hauer, Bernd Gruhn, Thomas Klingebiel, Peter Bader, Stefan Burdach, Peter Lang, Monika Sparber-Sauer, Monika Sparber-Sauer, Ewa Koscielniak, Ewa Koscielniak, Uwe Thiel

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Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells by Melina Vogt, Niklas Dienstbier, Julian Schliehe-Diecks, Katerina Scharov, Jia-Wey Tu, Philip Gebing, Julian Hogenkamp, Berna-Selin Bilen, Silke Furlan, Daniel Picard, Marc Remke, Layal Yasin, David Bickel, Munishikha Kalia, Alfredo Iacoangeli, Thomas Lenz, Kai Stühler, Aleksandra A. Pandyra, Julia Hauer, Ute Fischer, Rabea Wagener, Arndt Borkhardt, Sanil Bhatia

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S111: TREATMENT OF POST-TRANSPLANT RELAPSE IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS WITH BCP ALL USING CD19-CAR-T: A EUROPEAN RETROSPECTIVE ANALYSIS OF REAL-WORLD DATA by Peter Bader, Anna Alsonso, Andishe Attarbaschi, Nicole Bodmer, Halvard Bonig, Saskia Burridge, Jean-Pierre Bourquin, Veit Bücklein, Gunnar Cario, Macarena Oporto Espuelas, Tobias Feuhtinger, Anna Fuereder, Julia Hauer, Martin Hutter, Krzysztof Kałwak, Annette Künkele, Roland Meisel, Monika Mielcarek-Siedziuk, Ingo Müller, Sara Napolitano, Olaf Penack, Susana Rives, Claudia Rossig, Arend von Stackelberg, Andrea Jarisch, Sara Ghorashian, Adriana Balduzzi

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Recurrent Germline Variant in <i>RAD21</i> Predisposes Children to Lymphoblastic Leukemia or Lymphoma by Anne Schedel, Ulrike Anne Friedrich, Mina N. F. Morcos, Rabea Wagener, Juha Mehtonen, Titus Watrin, Claudia Saitta, Triantafyllia Brozou, Pia Michler, Carolin Walter, Asta Försti, Arka Baksi, Maria Menzel, Peter Horak, Nagarajan Paramasivam, Grazia Fazio, Robert J Autry, Stefan Fröhling, Meinolf Suttorp, Christoph Gertzen, Holger Gohlke, Sanil Bhatia, Karin Wadt, Kjeld Schmiegelow, Martin Dugas, Daniela Richter, Hanno Glimm, Merja Heinäniemi, Rolf Jessberger, Gianni Cazzaniga, Arndt Borkhardt, Julia Hauer, Franziska Auer

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Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID by Guillermo Rodríguez-Hernández, Friederike V. Opitz, Pilar Delgado, Carolin Walter, Ángel F. Álvarez-Prado, Inés González-Herrero, Franziska Auer, Ute Fischer, Stefan Janssen, Christoph Bartenhagen, Javier Raboso-Gallego, Ana Casado-García, Alberto Orfao, Oscar Blanco, Diego Alonso-López, Javier De Las Rivas, Sara González de Tena-Dávila, Markus Müschen, Martin Dugas, Francisco Javier García Criado, María Begoña García Cenador, Carolina Vicente-Dueñas, Julia Hauer, Almudena R. Ramiro, Isidro Sanchez-Garcia, Arndt Borkhardt

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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti... by Arndt Borkhardt, Nan Qin, Stephen T Keir, Darell D Bigner, Allison Cole, Matthias Wölfl, Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Joselyn Cruz-Cruz, Claus M Graef, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Thomas Kurz, Marc Remke, Siddhartha Mitra

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