Cross-population applications of genomics to understand the risk of multifactorial traits involving inflammation and immunity by Bana Alamad, Kate Elliott, Julian C. Knight

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Optimized protocol for CRISPR knockout of human iPSC-derived macrophages by Elena Navarro-Guerrero, Roberta Baronio, Chwen Tay, Julian C. Knight, Daniel V. Ebner

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SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile by Jia-Yuan Zhang, Justin P. Whalley, Julian C. Knight, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira

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Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis by Connor Davidson, Connor Davidson, B. Paul Wordsworth, Carla J. Cohen, Carla J. Cohen, Julian C. Knight, Matteo Vecellio, Matteo Vecellio

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Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance by Harindra E. Amarasinghe, Ping Zhang, Justin P. Whalley, Alice Allcock, Gabriele Migliorini, Andrew C. Brown, Giuseppe Scozzafava, Julian C. Knight

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Association between age and the host response in critically ill patients with sepsis by Erik H. A. Michels, Joe M. Butler, Tom D. Y. Reijnders, Olaf L. Cremer, Brendon P. Scicluna, Fabrice Uhel, Hessel Peters-Sengers, Marcus J. Schultz, Julian C. Knight, Lonneke A. van Vught, Tom van der Poll, MARS consortium

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Mortality-associated plasma proteome dynamics in a prospective multicentre sepsis cohortResearch in context by Lars Palmowski, Maike Weber, Malte Bayer, Yuxin Mi, Karin Schork, Martin Eisenacher, Hartmuth Nowak, Tim Rahmel, Lars Bergmann, Andrea Witowski, Björn Koos, Katharina Rump, Dominik Ziehe, Ulrich Limper, Dietrich Henzler, Stefan Felix Ehrentraut, Alexander Zarbock, Roman Fischer, Julian C. Knight, Michael Adamzik, Barbara Sitek, Thilo Bracht

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Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination by Zixi Yin, Ji-Li Chen, Yongxu Lu, Beibei Wang, Leila Godfrey, Alexander J. Mentzer, Xuan Yao, Guihai Liu, Dannielle Wellington, Yiqi Zhao, Peter A.C. Wing, Wanwisa Dejnirattisa, Piyada Supasa, Chang Liu, Philip Hublitz, Ryan Beveridge, Craig Waugh, Sally-Ann Clark, Kevin Clark, Paul Sopp, Timothy Rostron, Juthathip Mongkolsapaya, Gavin R. Screaton, Graham Ogg, Katie Ewer, Andrew J. Pollard, Sarah Gilbert, Julian C. Knight, Teresa Lambe, Geoffrey L. Smith, Tao Dong, Yanchun Peng

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A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology by Parsa Akbari, Dragana Vuckovic, Luca Stefanucci, Tao Jiang, Kousik Kundu, Roman Kreuzhuber, Erik L. Bao, Janine H. Collins, Kate Downes, Luigi Grassi, Jose A. Guerrero, Stephen Kaptoge, Julian C. Knight, Stuart Meacham, Jennifer Sambrook, Denis Seyres, Oliver Stegle, Jeffrey M. Verboon, Klaudia Walter, Nicholas A. Watkins, John Danesh, David J. Roberts, Emanuele Di Angelantonio, Vijay G. Sankaran, Mattia Frontini, Stephen Burgess, Taco Kuijpers, James E. Peters, Adam S. Butterworth, Willem H. Ouwehand, Nicole Soranzo, William J. Astle

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Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs by Praveen Weeratunga, Laura Denney, Joshua A. Bull, Emmanouela Repapi, Martin Sergeant, Rachel Etherington, Chaitanya Vuppussetty, Gareth D. H. Turner, Colin Clelland, Jeongmin Woo, Amy Cross, Fadi Issa, Carlos Eduardo de Andrea, Ignacio Melero Bermejo, David Sims, Simon McGowan, Yasemin-Xiomara Zurke, David J. Ahern, Eddie C. Gamez, Justin Whalley, Duncan Richards, Paul Klenerman, Claudia Monaco, Irina A. Udalova, Tao Dong, Agne Antanaviciute, Graham Ogg, Julian C. Knight, Helen M. Byrne, Stephen Taylor, Ling-Pei Ho

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Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection by Martina Milighetti, Yanchun Peng, Cedric Tan, Michal Mark, Gayathri Nageswaran, Suzanne Byrne, Tahel Ronel, Tom Peacock, Andreas Mayer, Aneesh Chandran, Joshua Rosenheim, Matthew Whelan, Xuan Yao, Guihai Liu, Suet Ling Felce, Tao Dong, Alexander J. Mentzer, Julian C. Knight, Francois Balloux, Erez Greenstein, Shlomit Reich-Zeliger, Corinna Pade, Joseph M. Gibbons, Amanda Semper, Tim Brooks, Ashley Otter, Daniel M. Altmann, Rosemary J. Boyton, Mala K. Maini, Aine McKnight, Charlotte Manisty, Thomas A. Treibel, James C. Moon, Mahdad Noursadeghi, Benny Chain

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SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections by Joshua Rosenheim, Rishi K. Gupta, Clare Thakker, Tiffeney Mann, Lucy C. K. Bell, Claire M. Broderick, Kieran Madon, Loukas Papargyris, Pete Dayananda, Andrew J. Kwok, James Greenan-Barrett, Helen R. Wagstaffe, Emily Conibear, Joe Fenn, Seran Hakki, Rik G. H. Lindeboom, Lisa M. Dratva, Briac Lemetais, Caroline M. Weight, Cristina Venturini, Myrsini Kaforou, Michael Levin, Mariya Kalinova, Alex J. Mann, Andrew Catchpole, Julian C. Knight, Marko Z. Nikolić, Sarah A. Teichmann, Ben Killingley, Wendy Barclay, Benjamin M. Chain, Ajit Lalvani, Robert S. Heyderman, Christopher Chiu, Mahdad Noursadeghi

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