The Most Common <i>VHL</i> Point Mutation R167Q in Hereditary VHL Disease Interferes with Cell Plasticity Regulation by Stéphanie Buart, Stéphane Terry, M’boyba Khadija Diop, Philippe Dessen, Sophie Couvé, Abdérémane Abdou, Julien Adam, Jérôme Thiery, Pierre Savagner, Salem Chouaib

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Lung microwave ablation – an in vivo swine tumor model experiment to evaluate ablation zones by Clara Prud’homme, Christophe Teriitehau, Julien Adam, Jimmy Kyaw Tun, Charles Roux, Antoine Hakime, Alexandre Delpla, Fréderic Deschamps, Thierry de Baere, Lambros Tselikas

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Multicenter automatic detection of invasive carcinoma on breast whole slide images. by Rémy Peyret, Nicolas Pozin, Stéphane Sockeel, Solène-Florence Kammerer-Jacquet, Julien Adam, Claire Bocciarelli, Yoan Ditchi, Christophe Bontoux, Thomas Depoilly, Loris Guichard, Elisabeth Lanteri, Marie Sockeel, Sophie Prévot

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Multicenter automatic detection of invasive carcinoma on breast whole slide images by Rémy Peyret, Nicolas Pozin, Stéphane Sockeel, Solène-Florence Kammerer-Jacquet, Julien Adam, Claire Bocciarelli, Yoan Ditchi, Christophe Bontoux, Thomas Depoilly, Loris Guichard, Elisabeth Lanteri, Marie Sockeel, Sophie Prévot

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Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade by Ines Malenica, Julien Adam, Stéphanie Corgnac, Laura Mezquita, Edouard Auclin, Isabelle Damei, Laetitia Grynszpan, Gwendoline Gros, Vincent de Montpréville, David Planchard, Nathalie Théret, Benjamin Besse, Fathia Mami-Chouaib

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Changes in DNA Damage Response Markers with Treatment in Advanced Ovarian Cancer by Paul Kubelac, Catherine Genestie, Aurelie Auguste, Soizick Mesnage, Audrey Le Formal, Patricia Pautier, Sebastien Gouy, Philippe Morice, Enrica Bentivegna, Amandine Maulard, Julien Adam, Patriciu Achimas-Cadariu, Alexandra Leary

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CD8+ T Lymphocytes Immune Depletion and LAG-3 Overexpression in Hodgkin Lymphoma Tumor Microenvironment Exposed to Anti-PD-1 Immunotherapy by Jean-Marie Michot, Severine Mouraud, Julien Adam, Julien Lazarovici, Camille Bigenwald, Charlotte Rigaud, Lambros Tselikas, Peggy Dartigues, Alina Danu, Amélie Bigorgne, Veronique Minard, David Ghez, Aurélien Marabelle, Laurence Zitvogel, Vincent Ribrag

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IDO Targeting in Sarcoma: Biological and Clinical Implications by Imane Nafia, Maud Toulmonde, Doriane Bortolotto, Assia Chaibi, Dominique Bodet, Christophe Rey, Valerie Velasco, Claire B. Larmonier, Loïc Cerf, Julien Adam, François Le Loarer, Ariel Savina, Alban Bessede, Antoine Italiano, Antoine Italiano

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Prognostic Factors of Long-Term Outcomes after Primary Chemo-Radiotherapy in Non-Metastatic Anal Squamous Cell Carcinoma: An International Bicentric Cohort by Soledad Iseas, Diego Prost, Sarah Bouchereau, Mariano Golubicki, Juan Robbio, Ana Oviedo, Mariana Coraglio, Mirta Kujaruk, Guillermo Méndez, Marcela Carballido, Enrique Roca, Louis Gros, Vincent De Parades, Nabil Baba-Hamed, Julien Adam, Martín Carlos Abba, Eric Raymond

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Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker? by Patricia Martin-Romano, Julien Adam, Jean-Yves Scoazec, Sébastien Gouy, Antonin Levy, Capucine Baldini, Stéphane Champiat, Jean-Charles Soria, Jean-Charles Soria, Jean-Charles Soria, Christophe Massard, Aurélien Marabelle, Eric Deutsch, Eric Deutsch, Eric Deutsch, Antoine Hollebecque

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Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibitio... by Florine A. Eggink, Inge C. Van Gool, Alexandra Leary, Pamela M. Pollock, Emma J. Crosbie, Linda Mileshkin, Ekaterina S. Jordanova, Julien Adam, Luke Freeman-Mills, David N. Church, Carien L. Creutzberg, Marco De Bruyn, Hans W. Nijman, Tjalling Bosse

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Chronic Plasma Exposure to Kinase Inhibitors in Patients with Oncogene-Addicted Non-Small Cell Lung Cancer by Arthur Geraud, Laura Mezquita, Edouard Auclin, David Combarel, Julia Delahousse, Paul Gougis, Christophe Massard, Cécile Jovelet, Caroline Caramella, Julien Adam, Charles Naltet, Pernelle Lavaud, Anas Gazzah, Ludovic Lacroix, Etienne Rouleau, Damien Vasseur, Olivier Mir, David Planchard, Angelo Paci, Benjamin Besse

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Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours by Aurélie Durgeau, Yasemin Virk, Gwendoline Gros, Elodie Voilin, Stéphanie Corgnac, Fayçal Djenidi, Jérôme Salmon, Julien Adam, Vincent de Montpréville, Pierre Validire, Soldano Ferrone, Salem Chouaib, Alexander Eggermont, Jean-Charles Soria, François Lemonnier, Eric Tartour, Nathalie Chaput, Benjamin Besse, Fathia Mami-Chouaib

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High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapie... by Maud Toulmonde, Carlo Lucchesi, Stéphanie Verbeke, Amandine Crombe, Julien Adam, Damien Geneste, Vanessa Chaire, Audrey Laroche-Clary, Raul Perret, François Bertucci, Frederic Bertolo, Laurence Bianchini, Bérengère Dadone-Montaudie, Todd Hembrough, Steve Sweet, Yeoun Jin Kim, Fabiola Cecchi, François Le Loarer, Antoine Italiano

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Impact of Intercurrent Introduction of Steroids on Clinical Outcomes in Advanced Non-Small-Cell Lung Cancer (NSCLC) Patients under Immune-Checkpoint Inhibitors (ICI) by Andrea De Giglio, Laura Mezquita, Edouard Auclin, Félix Blanc-Durand, Mariona Riudavets, Caroline Caramella, Gala Martinez, Jose Carlos Benitez, Patricia Martín-Romano, Lamiae El-Amarti, Lizza Hendriks, Roberto Ferrara, Charles Naltet, Pernelle Lavaud, Anas Gazzah, Julien Adam, David Planchard, Nathalie Chaput, Benjamin Besse

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378 Efficacy, safety and ancillary analyses of pembrolizumab in combination with nintedanib for the treatment of patients with relapsed advanced mesothelioma by Capucine Baldini, Francois-Xavier Danlos, Aurélien Marabelle, Jean-Charles Soria, Christophe Massard, Lydie Cassard, Julien Adam, David Planchard, Andreea Varga, Gérard Zalcman, Nathalie Chaput-Gras, Matthieu Texier, Severine Mouraud, Bastien Job, Diane Letourneur, Delphine Bredel, Salim Laghouati, Nathalie Droin, Aurelien Parpaleix, Audrey Rabeau

Single‐agent gemcitabine in patients with advanced, pre‐treated angiosarcoma: A multicenter, retrospective study by Sarah Watson, Benjamin Verret, Stanislas Ropert, Julien Adam, Rastislav Bahleda, Sylvain Briand, Andrea Cavalcanti, Ali N. Chamseddine, Charles Court, Elie Fadel, Matthieu Faron, Leila Haddag‐Miliani, Clémence Henon, Cécile Le Pechoux, Antonin Levy, Olaf Mercier, Carine Ngo, Charles Honoré, Axel Le Cesne, Olivier Mir

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Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti- PD1/PD-L1 immunotherapy in non-small cell lung can... by François Ghiringhelli, Frederic Bibeau, Laurent Greillier, Jean-David Fumet, Alis Ilie, Florence Monville, Caroline Laugé, Aurélie Catteau, Isabelle Boquet, Amine Majdi, Erwan Morgand, Youssef Oulkhouir, Nicolas Brandone, Julien Adam, Thomas Sbarrato, Alboukadel Kassambara, Jacques Fieschi, Stéphane Garcia, Anne Laure Lepage, Pascale Tomasini, Jérôme Galon

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CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched with Tc17 by Stéphanie Corgnac, Ines Malenica, Laura Mezquita, Edouard Auclin, Elodie Voilin, Jamila Kacher, Heloise Halse, Laetitia Grynszpan, Nicolas Signolle, Thibault Dayris, Marine Leclerc, Nathalie Droin, Vincent de Montpréville, Olaf Mercier, Pierre Validire, Jean-Yves Scoazec, Christophe Massard, Salem Chouaib, David Planchard, Julien Adam, Benjamin Besse, Fathia Mami-Chouaib

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Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome by Kim L. Brunekreeft, Sterre T. Paijens, Maartje C.A. Wouters, Fenne L. Komdeur, Florine A. Eggink, Joyce M. Lubbers, Hagma H. Workel, Elisabeth C. Van Der Slikke, Noor E.J. Pröpper, Ninke Leffers, Julien Adam, Harry Pijper, Annechien Plat, Arjan Kol, Hans W. Nijman, Marco De Bruyn

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