Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism by Nathanael A Caveney, Naotaka Tsutsumi, K Christopher Garcia

Get full text

Structure of the IL-27 quaternary receptor signaling complex by Nathanael A Caveney, Caleb R Glassman, Kevin M Jude, Naotaka Tsutsumi, K Christopher Garcia

Get full text

Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling. by Vincent C Luca, Yi Miao, Xingnan Li, Michael J Hollander, Calvin J Kuo, K Christopher Garcia

Get full text

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers by Ignacio Moraga, Jamie B Spangler, Juan L Mendoza, Milica Gakovic, Tom S Wehrman, Peter Krutzik, K Christopher Garcia

Get full text

Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag. by Aimee Shen, Patrick J Lupardus, Montse Morell, Elizabeth L Ponder, A Masoud Sadaghiani, K Christopher Garcia, Matthew Bogyo

Get full text

Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform by Dirk H Siepe, Lukas T Henneberg, Steven C Wilson, Gaelen T Hess, Michael C Bassik, Kai Zinn, K Christopher Garcia

Get full text

Structural basis of Janus kinase trans-activation by Nathanael A. Caveney, Robert A. Saxton, Deepa Waghray, Caleb R. Glassman, Naotaka Tsutsumi, Stevan R. Hubbard, K. Christopher Garcia

Get full text

Structural insights into the mechanism of leptin receptor activation by Robert A. Saxton, Nathanael A. Caveney, Maria Dolores Moya-Garzon, Karsten D. Householder, Grayson E. Rodriguez, Kylie A. Burdsall, Jonathan Z. Long, K. Christopher Garcia

Get full text

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance. by Kalliopi Pervolaraki, Soheil Rastgou Talemi, Dorothee Albrecht, Felix Bormann, Connor Bamford, Juan L Mendoza, K Christopher Garcia, John McLauchlan, Thomas Höfer, Megan L Stanifer, Steeve Boulant

Get full text

Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling by Naotaka Tsutsumi, Somnath Mukherjee, Deepa Waghray, Claudia Y Janda, Kevin M Jude, Yi Miao, John S Burg, Nanda Gowtham Aduri, Anthony A Kossiakoff, Cornelius Gati, K Christopher Garcia

Get full text

Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity by Juan L Mendoza, Suzanne Fischer, Marvin H Gee, Lilian H Lam, Simon Brackenridge, Fiona M Powrie, Michael Birnbaum, Andrew J McMichael, K Christopher Garcia, Geraldine M Gillespie

Get full text

A structural blueprint for interleukin-21 signal modulation by Gita C. Abhiraman, Theodora U.J. Bruun, Nathanael A. Caveney, Leon L. Su, Robert A. Saxton, Qian Yin, Shaogeng Tang, Mark M. Davis, Kevin M. Jude, K. Christopher Garcia

Get full text

Localized ablative immunotherapy drives de novo CD8+ T-cell responses to poorly immunogenic tumors by Mark M Davis, Saghar Kaabinejadian, Abdul Rafeh Naqash, Ashley R Hoover, Jason R Krawic, Xiao-Hong Sun, Qian Yin, Xinbo Yang, K Christopher Garcia, William H Hildebrand, Wei R Chen

Get full text

Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo by Ricardo A Fernandes, Chaoran Li, Gang Wang, Xinbo Yang, Christina S Savvides, Caleb R Glassman, Shen Dong, Eric Luxenberg, Leah V Sibener, Michael E Birnbaum, Christophe Benoist, Diane Mathis, K Christopher Garcia

Get full text

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy by Timothy F Miles, Katja Spiess, Kevin M Jude, Naotaka Tsutsumi, John S Burg, Jessica R Ingram, Deepa Waghray, Gertrud M Hjorto, Olav Larsen, Hidde L Ploegh, Mette M Rosenkilde, K Christopher Garcia

Get full text

A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages. by Connor G G Bamford, Elihu Aranday-Cortes, Ines Cordeiro Filipe, Swathi Sukumar, Daniel Mair, Ana da Silva Filipe, Juan L Mendoza, K Christopher Garcia, Shaohua Fan, Sarah A Tishkoff, John McLauchlan

Get full text

Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development by Hanqing Li, Ash Watson, Agnieszka Olechwier, Michael Anaya, Siamak K Sorooshyari, Dermott P Harnett, Hyung-Kook (Peter) Lee, Jost Vielmetter, Mario A Fares, K Christopher Garcia, Engin Özkan, Juan-Pablo Labrador, Kai Zinn

Get full text

Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling by Martti Maimets, Marianne Terndrup Pedersen, Jordi Guiu, Jes Dreier, Malte Thodberg, Yasuko Antoku, Pawel J. Schweiger, Leonor Rib, Raul Bardini Bressan, Yi Miao, K. Christopher Garcia, Albin Sandelin, Palle Serup, Kim B. Jensen

Get full text

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments by David Richter, Ignacio Moraga, Hauke Winkelmann, Oliver Birkholz, Stephan Wilmes, Markos Schulte, Michael Kraich, Hella Kenneweg, Oliver Beutel, Philipp Selenschik, Dirk Paterok, Martynas Gavutis, Thomas Schmidt, K. Christopher Garcia, Thomas D. Müller, Jacob Piehler

Get full text

Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2 by Brendan L. Horton, Alicia D. D’Souza, Maria Zagorulya, Chloe V. McCreery, Gita C. Abhiraman, Lora Picton, Allison Sheen, Yash Agarwal, Noor Momin, K. Dane Wittrup, Forest M. White, K. Christopher Garcia, Stefani Spranger

Get full text