Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation af Aleksandra Levina, Kaelin D. Fleming, John E. Burke, Thomas A. Leonard

Få fuldtekst

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors af Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris, Brandon E Moeller, Matthias P Wymann, Rommie E Amaro, John E Burke

Få fuldtekst

The middle lipin domain adopts a membrane-binding dimeric protein fold af Weijing Gu, Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang, Nimi M. Patel, Yong Mi Choi, John E. Burke, Karen Reue, Michael V. Airola

Få fuldtekst

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation af Yong Mi Choi, Dalila Ajjaji, Kaelin D. Fleming, Peter P. Borbat, Meredith L. Jenkins, Brandon E. Moeller, Shaveen Fernando, Surita R. Bhatia, Jack H. Freed, John E. Burke, Abdou Rachid Thiam, Michael V. Airola

Få fuldtekst

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs af Manoj K. Rathinaswamy, Meredith L. Jenkins, Benjamin R. Duewell, Xuxiao Zhang, Noah J. Harris, John T. Evans, Jordan T.B. Stariha, Udit Dalwadi, Kaelin D. Fleming, Harish Ranga-Prasad, Calvin K. Yip, Roger L. Williams, Scott D. Hansen, John E. Burke

Få fuldtekst