Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation nork Aleksandra Levina, Kaelin D. Fleming, John E. Burke, Thomas A. Leonard

Testu osoa

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors nork Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris, Brandon E Moeller, Matthias P Wymann, Rommie E Amaro, John E Burke

Testu osoa

The middle lipin domain adopts a membrane-binding dimeric protein fold nork Weijing Gu, Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang, Nimi M. Patel, Yong Mi Choi, John E. Burke, Karen Reue, Michael V. Airola

Testu osoa

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation nork Yong Mi Choi, Dalila Ajjaji, Kaelin D. Fleming, Peter P. Borbat, Meredith L. Jenkins, Brandon E. Moeller, Shaveen Fernando, Surita R. Bhatia, Jack H. Freed, John E. Burke, Abdou Rachid Thiam, Michael V. Airola

Testu osoa

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs nork Manoj K. Rathinaswamy, Meredith L. Jenkins, Benjamin R. Duewell, Xuxiao Zhang, Noah J. Harris, John T. Evans, Jordan T.B. Stariha, Udit Dalwadi, Kaelin D. Fleming, Harish Ranga-Prasad, Calvin K. Yip, Roger L. Williams, Scott D. Hansen, John E. Burke

Testu osoa