Structure of the human mTOR Complex I and its implications for rapamycin inhibition by Yip, Calvin K., Murata, Kazuyoshi, Walz, Thomas, Kang, Seong A., Sabatini, David

Get full text
Get full text

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway by Peterson, Timothy R., Sengupta, Shomit S., Harris, Thurl E., Carpenter, Anne E., Kang, Seong A., Balderas, Eric, Guertin, David A., Madden, Katherine L., Finck, Brian N., Sabatini, David M., Kang, Seong A., Peterson, Timothy Richard, Sengupta, Shomit, Sabatini, David

Get full text
Get full text

Discovery of 9-(6-aminopyridin-3-yl)-1-(3- (trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treat... by Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Ahmed, Tausif, Gray, Nathanael S., Sabatini, David

Get full text
Get full text

Native capillary isoelectric focusing for the separation of protein complex isoforms and subcomplexes by Fonslow, Bryan R., Kang, Seong A., Gestaut, Daniel R., Graczyk, Beth, Davis, Trisha N., Yates III, John R., Sabatini, David

Get full text
Get full text

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival by Peterson, Timothy R., Laplante, Mathieu, Thoreen, Carson C., Sancak, Yasemin, Kang, Seong A., Kuehl, W. Michael, Gray, Nathanael S., Sabatini, David M.

Get full text
Get full text

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapa... by Liu, Qingsong, Chang, Jae Won, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Markhard, Andrew L., Hur, Wooyoung, Zhang, Jianming, Sim, Taebo, Gray, Nathanael S., Sabatini, David

Get full text
Get full text

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin by Kang, Seong A., Cervantes, Christopher L., Lim, Daniel Cham-Chin, Ottina, Kathleen, Lou, Hua Jane, Gray, Nathanael S., Turk, Benjamin E., Pacold, Michael Edward, Yaffe, Michael B, Sabatini, David

Get full text
Get full text
Get full text
Get full text

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin by Cervantes, Christopher L., Lim, Daniel Cham-Chin, Kang, Seong A., Pacold, Michael E., Lou, Hua Jane, Ottina, Kathleen, Gray, Nathanael S., Turk, Benjamin E., Yaffe, Michael B, Sabatini, David

Get full text
Get full text
Get full text

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling by Rameseder, J., Zhang, Y., Ottina, Kathleen, Lim, D., Choi, Y., Gray, Nathanael S., Yaffe, M. B., Marto, Jarrod A., Hsu, Peggy P., Kang, Seong A., Peterson, Timothy R., Sabatini, David M.

Get full text
Get full text

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR by Liu, Qingsong, Xu, Chunxiao, Kirubakaran, Sivapriya, Zhang, Xin, Hur, Wooyoung, Kwiatkowski, Nicholas P., Wang, Jinhua, Westover, Kenneth D., Gao, Peng, Ercan, Dalia, Niepel, Mario, Thoreen, Carson C., Kang, Seong A., Patricelli, Matthew P., Wang, Yuchuan, Tupper, Tanya, Altabef, Abigail, Kawamura, Hidemasa, Held, Kathryn D., Chou, Danny M., Elledge, Stephen J., Janne, Pasi A., Wong, Kwok-Kin, Gray, Nathanael S., Sabatini, David, Liu, Yan

Get full text
Get full text