Pattern recognition analysis of proton nuclear magnetic resonance spectra of brain tissue extracts from rats anesthetized with propofol or isoflurane. by Hiroshi Kawaguchi, Keiko Hirakawa, Kensuke Miyauchi, Kaoru Koike, Youkichi Ohno, Atsuhiro Sakamoto

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Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression. by Masato Ooka, Takuya Abe, Kosai Cho, Kaoru Koike, Shunichi Takeda, Kouji Hirota

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Predictive Factors of the Fatality of Motor Vehicle Passengers Involved in Far-Side Lateral Collisions: A National Crash Database Study by Akane Masumitsu, Masahito Hitosugi, Mineko Baba, Mami Nakamura, Kaoru Koike, Hitoshi Ida, Masashi Aoki

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Time–frequency analysis of serum with proton nuclear magnetic resonance for diagnosis of pancreatic cancer by Asahi Sato, Toshihiko Masui, Akitada Yogo, Takashi Ito, Keiko Hirakawa, Yoshimasa Kanawaku, Kaoru Koike, Shinji Uemoto

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The development and validation of a “5A” severity scale for predicting in-hospital mortality after accidental hypothermia from J-point registry data by Yohei Okada, Tasuku Matsuyama, Sachiko Morita, Naoki Ehara, Nobuhiro Miyamae, Takaaki Jo, Yasuyuki Sumida, Nobunaga Okada, Makoto Watanabe, Masahiro Nozawa, Ayumu Tsuruoka, Yoshihiro Fujimoto, Yoshiki Okumura, Tetsuhisa Kitamura, Shungo Yamamoto, Ryoji Iiduka, Kaoru Koike

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Correction to: The development and validation of a “5A” severity scale for predicting in-hospital mortality after accidental hypothermia from J-point registry data by Yohei Okada, Tasuku Matsuyama, Sachiko Morita, Naoki Ehara, Nobuhiro Miyamae, Takaaki Jo, Yasuyuki Sumida, Nobunaga Okada, Makoto Watanabe, Masahiro Nozawa, Ayumu Tsuruoka, Yoshihiro Fujimoto, Yoshiki Okumura, Tetsuhisa Kitamura, Shungo Yamamoto, Ryoji Iiduka, Kaoru Koike

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ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair. by Masataka Tsuda, Kosai Cho, Masato Ooka, Naoto Shimizu, Reiko Watanabe, Akira Yasui, Yuka Nakazawa, Tomoo Ogi, Hiroshi Harada, Keli Agama, Jun Nakamura, Ryuta Asada, Haruna Fujiike, Tetsushi Sakuma, Takashi Yamamoto, Junko Murai, Masahiro Hiraoka, Kaoru Koike, Yves Pommier, Shunichi Takeda, Kouji Hirota

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Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2‐mutation carriers by Tomoharu Mori, Yusuke Okamoto, Anfeng Mu, Yoshimi Ide, Akiyo Yoshimura, Noriko Senda, Yukiko Inagaki‐Kawata, Masahiro Kawashima, Hiroyuki Kitao, Eriko Tokunaga, Yasuo Miyoshi, Shozo Ohsumi, Koichiro Tsugawa, Tomohiko Ohta, Toyomasa Katagiri, Shigeru Ohtsuru, Kaoru Koike, Seishi Ogawa, Masakazu Toi, Hiroji Iwata, Seigo Nakamura, Keitaro Matsuo, Minoru Takata

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Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: a prospective observational cohort study in Japan by Yohei Okada, Takeyuki Kiguchi, Taro Irisawa, Kazuhisa Yoshiya, Tomoki Yamada, Koichi Hayakawa, Kazuo Noguchi, Tetsuro Nishimura, Takuya Ishibe, Yoshiki Yagi, Masafumi Kishimoto, Hiroshi Shintani, Yasuyuki Hayashi, Taku Sogabe, Takaya Morooka, Haruko Sakamoto, Keitaro Suzuki, Fumiko Nakamura, Norihiro Nishioka, Tasuku Matsuyama, Satoshi Matsui, Takeshi Shimazu, Kaoru Koike, Takashi Kawamura, Tetsuhisa Kitamura, Taku Iwami

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Association between low pH and unfavorable neurological outcome among out-of-hospital cardiac arrest patients treated by extracorporeal CPR: a prospective observational cohort stud... by Yohei Okada, Takeyuki Kiguchi, Taro Irisawa, Kazuhisa Yoshiya, Tomoki Yamada, Koichi Hayakawa, Kazuo Noguchi, Tetsuro Nishimura, Takuya Ishibe, Yoshiki Yagi, Masafumi Kishimoto, Hiroshi Shintani, Yasuyuki Hayashi, Taku Sogabe, Takaya Morooka, Haruko Sakamoto, Keitaro Suzuki, Fumiko Nakamura, Norihiro Nishioka, Tasuku Matsuyama, Junya Sado, Satoshi Matsui, Takeshi Shimazu, Kaoru Koike, Takashi Kawamura, Tetsuhisa Kitamura, Taku Iwami, on behalf of the CRITICAL Study Group Investigators

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Assessing and managing frailty in emergency laparotomy: a WSES position paper by Brian W. C. A. Tian, Philip F. Stahel, Edoardo Picetti, Giampiero Campanelli, Salomone Di Saverio, Ernest Moore, Denis Bensard, Boris Sakakushev, Joseph Galante, Gustavo P. Fraga, Kaoru Koike, Isidoro Di Carlo, Giovanni D. Tebala, Ari Leppaniemi, Edward Tan, Dimitris Damaskos, Nicola De’Angelis, Andreas Hecker, Michele Pisano, YunfengCui, Ron V. Maier, Belinda De Simone, Francesco Amico, Marco Ceresoli, Manos Pikoulis, Dieter G. Weber, Walt Biffl, Solomon Gurmu Beka, Fikri M. Abu-Zidan, Massimo Valentino, Federico Coccolini, Yoram Kluger, Massimo Sartelli, Vanni Agnoletti, Mircea Chirica, Francesca Bravi, Ibrahima Sall, Fausto Catena

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Management of complicated diaphragmatic hernia in the acute setting: a WSES position paper by Mario Giuffrida, Gennaro Perrone, Fikri Abu-Zidan, Vanni Agnoletti, Luca Ansaloni, Gian Luca Baiocchi, Cino Bendinelli, Walter L. Biffl, Luigi Bonavina, Francesca Bravi, Paolo Carcoforo, Marco Ceresoli, Alain Chichom-Mefire, Federico Coccolini, Raul Coimbra, Nicola de’Angelis, Marc de Moya, Belinda De Simone, Salomone Di Saverio, Gustavo Pereira Fraga, Joseph Galante, Rao Ivatury, Jeffry Kashuk, Michael Denis Kelly, Andrew W. Kirkpatrick, Yoram Kluger, Kaoru Koike, Ari Leppaniemi, Ronald V. Maier, Ernest Eugene Moore, Andrew Peitzmann, Boris Sakakushev, Massimo Sartelli, Michael Sugrue, Brian W. C. A. Tian, Richard Ten Broek, Carlo Vallicelli, Imtaz Wani, Dieter G. Weber, Giovanni Docimo, Fausto Catena

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Enhanced perioperative care in emergency general surgery: the WSES position paper by Marco Ceresoli, Marco Braga, Nicola Zanini, Fikri M. Abu-Zidan, Dario Parini, Thomas Langer, Massimo Sartelli, Dimitrios Damaskos, Walter L. Biffl, Francesco Amico, Luca Ansaloni, Zsolt J. Balogh, Luigi Bonavina, Ian Civil, Enrico Cicuttin, Mircea Chirica, Yunfeng Cui, Belinda De Simone, Isidoro Di Carlo, Andreas Fette, Giuseppe Foti, Michele Fogliata, Gustavo P. Fraga, Paola Fugazzola, Joseph M. Galante, Solomon Gurmu Beka, Andreas Hecker, Johannes Jeekel, Andrew W. Kirkpatrick, Kaoru Koike, Ari Leppäniemi, Ingo Marzi, Ernest E. Moore, Edoardo Picetti, Emmanouil Pikoulis, Michele Pisano, Mauro Podda, Boris E. Sakakushev, Vishal G. Shelat, Edward Tan, Giovanni D. Tebala, George Velmahos, Dieter G. Weber, Vanni Agnoletti, Yoram Kluger, Gianluca Baiocchi, Fausto Catena, Federico Coccolini

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The LIFE TRIAD of emergency general surgery by Federico Coccolini, Massimo Sartelli, Yoram Kluger, Aleksei Osipov, Yunfeng Cui, Solomon Gurmu Beka, Andrew Kirkpatrick, Ibrahima Sall, Ernest E. Moore, Walter L. Biffl, Andrey Litvin, Michele Pisano, Stefano Magnone, Edoardo Picetti, Nicola de Angelis, Philip Stahel, Luca Ansaloni, Edward Tan, Fikri Abu-Zidan, Marco Ceresoli, Andreas Hecker, Osvaldo Chiara, Gabriele Sganga, Vladimir Khokha, Salomone di Saverio, Boris Sakakushev, Giampiero Campanelli, Gustavo Fraga, Imtiaz Wani, Richard ten Broek, Enrico Cicuttin, Camilla Cremonini, Dario Tartaglia, Kjetil Soreide, Joseph Galante, Marc de Moya, Kaoru Koike, Belinda De Simone, Zsolt Balogh, Francesco Amico, Vishal Shelat, Emmanouil Pikoulis, Isidoro Di Carlo, Luigi Bonavina, Ari Leppaniemi, Ingo Marzi, Rao Ivatury, Jim Khan, Ronald V. Maier, Timothy C. Hardcastle, Arda Isik, Mauro Podda, Matti Tolonen, Kemal Rasa, Pradeep H. Navsaria, Zaza Demetrashvili, Antonio Tarasconi, Paolo Carcoforo, Maria Grazia Sibilla, Gian Luca Baiocchi, Nikolaos Pararas, Dieter Weber, Massimo Chiarugi, Fausto Catena

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2017 update of the WSES guidelines for emergency repair of complicated abdominal wall hernias by Arianna Birindelli, Massimo Sartelli, Salomone Di Saverio, Federico Coccolini, Luca Ansaloni, Gabrielle H. van Ramshorst, Giampiero Campanelli, Vladimir Khokha, Ernest E. Moore, Andrew Peitzman, George Velmahos, Frederick Alan Moore, Ari Leppaniemi, Clay Cothren Burlew, Walter L. Biffl, Kaoru Koike, Yoram Kluger, Gustavo P. Fraga, Carlos A. Ordonez, Matteo Novello, Ferdinando Agresta, Boris Sakakushev, Igor Gerych, Imtiaz Wani, Michael D. Kelly, Carlos Augusto Gomes, Mario Paulo Faro, Antonio Tarasconi, Zaza Demetrashvili, Jae Gil Lee, Nereo Vettoretto, Gianluca Guercioni, Roberto Persiani, Cristian Tranà, Yunfeng Cui, Kenneth Y. Y. Kok, Wagih M. Ghnnam, Ashraf El-Sayed Abbas, Norio Sato, Sanjay Marwah, Muthukumaran Rangarajan, Offir Ben-Ishay, Abdul Rashid K Adesunkanmi, Helmut Alfredo Segovia Lohse, Jakub Kenig, Stefano Mandalà, Raul Coimbra, Aneel Bhangu, Nigel Suggett, Antonio Biondi, Nazario Portolani, Gianluca Baiocchi, Andrew W Kirkpatrick, Rodolfo Scibé, Michael Sugrue, Osvaldo Chiara, Fausto Catena

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Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery by Miklosh Bala, Fausto Catena, Jeffry Kashuk, Belinda De Simone, Carlos Augusto Gomes, Dieter Weber, Massimo Sartelli, Federico Coccolini, Yoram Kluger, Fikri M. Abu-Zidan, Edoardo Picetti, Luca Ansaloni, Goran Augustin, Walter L. Biffl, Marco Ceresoli, Osvaldo Chiara, Massimo Chiarugi, Raul Coimbra, Yunfeng Cui, Dimitris Damaskos, Salomone Di Saverio, Joseph M. Galante, Vladimir Khokha, Andrew W. Kirkpatrick, Kenji Inaba, Ari Leppäniemi, Andrey Litvin, Andrew B. Peitzman, Vishal G. Shelat, Michael Sugrue, Matti Tolonen, Sandro Rizoli, Ibrahima Sall, Solomon G. Beka, Isidoro Di Carlo, Richard Ten Broek, Chirika Mircea, Giovanni Tebala, Michele Pisano, Harry van Goor, Ronald V. Maier, Hans Jeekel, Ian Civil, Andreas Hecker, Edward Tan, Kjetil Soreide, Matthew J. Lee, Imtiaz Wani, Luigi Bonavina, Mark A. Malangoni, Kaoru Koike, George C. Velmahos, Gustavo P. Fraga, Andreas Fette, Nicola de’Angelis, Zsolt J. Balogh, Thomas M. Scalea, Gabriele Sganga, Michael D. Kelly, Jim Khan, Philip F. Stahel, Ernest E. Moore

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The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections by Massimo Sartelli, Alain Chichom-Mefire, Francesco M. Labricciosa, Timothy Hardcastle, Fikri M. Abu-Zidan, Abdulrashid K. Adesunkanmi, Luca Ansaloni, Miklosh Bala, Zsolt J. Balogh, Marcelo A. Beltrán, Offir Ben-Ishay, Walter L. Biffl, Arianna Birindelli, Miguel A. Cainzos, Gianbattista Catalini, Marco Ceresoli, Asri Che Jusoh, Osvaldo Chiara, Federico Coccolini, Raul Coimbra, Francesco Cortese, Zaza Demetrashvili, Salomone Di Saverio, Jose J. Diaz, Valery N. Egiev, Paula Ferrada, Gustavo P. Fraga, Wagih M. Ghnnam, Jae Gil Lee, Carlos A. Gomes, Andreas Hecker, Torsten Herzog, Jae Il Kim, Kenji Inaba, Arda Isik, Aleksandar Karamarkovic, Jeffry Kashuk, Vladimir Khokha, Andrew W. Kirkpatrick, Yoram Kluger, Kaoru Koike, Victor Y. Kong, Ari Leppaniemi, Gustavo M. Machain, Ronald V. Maier, Sanjay Marwah, Michael E. McFarlane, Giulia Montori, Ernest E. Moore, Ionut Negoi, Iyiade Olaoye, Abdelkarim H. Omari, Carlos A. Ordonez, Bruno M. Pereira, Gerson A. Pereira Júnior, Guntars Pupelis, Tarcisio Reis, Boris Sakakushev, Norio Sato, Helmut A. Segovia Lohse, Vishal G. Shelat, Kjetil Søreide, Waldemar Uhl, Jan Ulrych, Harry Van Goor, George C. Velmahos, Kuo-Ching Yuan, Imtiaz Wani, Dieter G. Weber, Sanoop K. Zachariah, Fausto Catena

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Raising concerns about the Sepsis-3 definitions by Massimo Sartelli, Yoram Kluger, Luca Ansaloni, Timothy C. Hardcastle, Jordi Rello, Richard R. Watkins, Matteo Bassetti, Eleni Giamarellou, Federico Coccolini, Fikri M. Abu-Zidan, Abdulrashid K. Adesunkanmi, Goran Augustin, Gian L. Baiocchi, Miklosh Bala, Oussema Baraket, Marcelo A. Beltran, Asri Che Jusoh, Zaza Demetrashvili, Belinda De Simone, Hamilton P. de Souza, Yunfeng Cui, R. Justin Davies, Sameer Dhingra, Jose J. Diaz, Salomone Di Saverio, Agron Dogjani, Mutasim M. Elmangory, Mushira A. Enani, Paula Ferrada, Gustavo P. Fraga, Sabrina Frattima, Wagih Ghnnam, Carlos A. Gomes, Souha S. Kanj, Aleksandar Karamarkovic, Jakub Kenig, Faryal Khamis, Vladimir Khokha, Kaoru Koike, Kenneth Y. Y. Kok, Arda Isik, Francesco M. Labricciosa, Rifat Latifi, Jae G. Lee, Andrey Litvin, Gustavo M. Machain, Ramiro Manzano-Nunez, Piotr Major, Sanjay Marwah, Michael McFarlane, Ziad A. Memish, Cristian Mesina, Ernest E. Moore, Frederick A. Moore, Noel Naidoo, Ionut Negoi, Richard Ofori-Asenso, Iyiade Olaoye, Carlos A. Ordoñez, Mouaqit Ouadii, Ciro Paolillo, Edoardo Picetti, Tadeja Pintar, Alfredo Ponce-de-Leon, Guntars Pupelis, Tarcisio Reis, Boris Sakakushev, Hossein Samadi Kafil, Norio Sato, Jay N. Shah, Boonying Siribumrungwong, Peep Talving, Cristian Tranà, Jan Ulrych, Kuo-Ching Yuan, Fausto Catena

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The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardship—results from an international cross-sectional survey by Massimo Sartelli, Francesco M. Labricciosa, Pamela Barbadoro, Leonardo Pagani, Luca Ansaloni, Adrian J. Brink, Jean Carlet, Ashish Khanna, Alain Chichom-Mefire, Federico Coccolini, Salomone Di Saverio, Addison K. May, Pierluigi Viale, Richard R. Watkins, Luigia Scudeller, Lilian M. Abbo, Fikri M. Abu-Zidan, Abdulrashid K. Adesunkanmi, Sara Al-Dahir, Majdi N. Al-Hasan, Halil Alis, Carlos Alves, André R. Araujo da Silva, Goran Augustin, Miklosh Bala, Philip S. Barie, Marcelo A. Beltrán, Aneel Bhangu, Belefquih Bouchra, Stephen M. Brecher, Miguel A. Caínzos, Adrian Camacho-Ortiz, Marco Catani, Sujith J. Chandy, Asri Che Jusoh, Jill R. Cherry-Bukowiec, Osvaldo Chiara, Elif Colak, Oliver A. Cornely, Yunfeng Cui, Zaza Demetrashvili, Belinda De Simone, Jan J. De Waele, Sameer Dhingra, Francesco Di Marzo, Agron Dogjani, Gereltuya Dorj, Laurent Dortet, Therese M. Duane, Mutasim M. Elmangory, Mushira A. Enani, Paula Ferrada, J. Esteban Foianini, Mahir Gachabayov, Chinmay Gandhi, Wagih Mommtaz Ghnnam, Helen Giamarellou, Georgios Gkiokas, Harumi Gomi, Tatjana Goranovic, Ewen A. Griffiths, Rosio I. Guerra Gronerth, Julio C. Haidamus Monteiro, Timothy C. Hardcastle, Andreas Hecker, Adrien M. Hodonou, Orestis Ioannidis, Arda Isik, Katia A. Iskandar, Hossein S. Kafil, Souha S. Kanj, Lewis J. Kaplan, Garima Kapoor, Aleksandar R. Karamarkovic, Jakub Kenig, Ivan Kerschaever, Faryal Khamis, Vladimir Khokha, Ronald Kiguba, Hong B. Kim, Wen-Chien Ko, Kaoru Koike, Iryna Kozlovska, Anand Kumar, Leonel Lagunes, Rifat Latifi, Jae G. Lee, Young R. Lee, Ari Leppäniemi, Yousheng Li, Stephen Y. Liang, Warren Lowman, Gustavo M. Machain, Marc Maegele, Piotr Major, Sydney Malama, Ramiro Manzano-Nunez, Athanasios Marinis, Isidro Martinez Casas, Sanjay Marwah, Emilio Maseda, Michael E. McFarlane, Ziad Memish, Dominik Mertz, Cristian Mesina, Shyam K. Mishra, Ernest E. Moore, Akutu Munyika, Eleftherios Mylonakis, Lena Napolitano, Ionut Negoi, Milica D. Nestorovic, David P. Nicolau, Abdelkarim H. Omari, Carlos A. Ordonez, José-Artur Paiva, Narayan D. Pant, Jose G. Parreira, Michal Pędziwiatr, Bruno M. Pereira, Alfredo Ponce-de-Leon, Garyphallia Poulakou, Jacobus Preller, Céline Pulcini, Guntars Pupelis, Martha Quiodettis, Timothy M. Rawson, Tarcisio Reis, Miran Rems, Sandro Rizoli, Jason Roberts, Nuno Rocha Pereira, Jesús Rodríguez-Baño, Boris Sakakushev, James Sanders, Natalia Santos, Norio Sato, Robert G. Sawyer, Sandro Scarpelini, Loredana Scoccia, Nusrat Shafiq, Vishalkumar Shelat, Costi D. Sifri, Boonying Siribumrungwong, Kjetil Søreide, Rodolfo Soto, Hamilton P. de Souza, Peep Talving, Ngo Tat Trung, Jeffrey M. Tessier, Mario Tumbarello, Jan Ulrych, Selman Uranues, Harry Van Goor, Andras Vereczkei, Florian Wagenlehner, Yonghong Xiao, Kuo-Ching Yuan, Agnes Wechsler-Fördös, Jean-Ralph Zahar, Tanya L. Zakrison, Brian Zuckerbraun, Wietse P. Zuidema, Fausto Catena

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