Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viability. by Emily Peak, Iain W Chalmers, Karl F Hoffmann

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Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities [version 1; peer review: 1 approved, 2 approved with reservations... by Gilda Padalino, Iain W. Chalmers, Andrea Brancale, Karl F. Hoffmann

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Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni by Gilda Padalino, Salvatore Ferla, Andrea Brancale, Iain W. Chalmers, Karl F. Hoffmann

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Identification of anti-schistosomal, anthelmintic and anti-parasitic compounds curated and text-mined from the scientific literature [version 1; peer review: 2 approved] by Noel M. O'Boyle, Gilda Padalino, Matthew Berriman, Karl F. Hoffmann, Avril Coghlan

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The diterpenoid 7-keto-sempervirol, derived from Lycium chinense, displays anthelmintic activity against both Schistosoma mansoni and Fasciola hepatica. by Jennifer Edwards, Martha Brown, Emily Peak, Barbara Bartholomew, Robert J Nash, Karl F Hoffmann

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Using ChEMBL to Complement Schistosome Drug Discovery by Gilda Padalino, Avril Coghlan, Giampaolo Pagliuca, Josephine E. Forde-Thomas, Matthew Berriman, Karl F. Hoffmann

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Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni. by Kathrin K Geyer, Sabrina E Munshi, Helen L Whiteland, Narcis Fernandez-Fuentes, Dylan W Phillips, Karl F Hoffmann

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Use of genomic DNA as an indirect reference for identifying gender-associated transcripts in morphologically identical, but chromosomally distinct, Schistosoma mansoni cercariae. by Jennifer M Fitzpatrick, Anna V Protasio, Andrew J McArdle, Gary A Williams, David A Johnston, Karl F Hoffmann

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The Anti-mycobacterial Activity of a Diterpenoid-Like Molecule Operates Through Nitrogen and Amino Acid Starvation by Alessandra Crusco, Alessandra Crusco, Rafael Baptista, Sumana Bhowmick, Manfred Beckmann, Luis A. J. Mur, Andrew D. Westwell, Karl F. Hoffmann

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Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses. by Jennifer M Fitzpatrick, Emily Peak, Samirah Perally, Iain W Chalmers, John Barrett, Timothy P Yoshino, Alasdair C Ivens, Karl F Hoffmann

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Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal. by Helen Whiteland, Alessandra Crusco, Lisa W Bloemberg, Jamie Tibble-Howlings, Josephine Forde-Thomas, Avril Coghlan, Patrick J Murphy, Karl F Hoffmann

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The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses. by Colin M Fitzsimmons, Frances M Jones, Alex Stearn, Iain W Chalmers, Karl F Hoffmann, Jakub Wawrzyniak, Shona Wilson, Narcis B Kabatereine, David W Dunne

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Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni. by David Roquis, Aaron Taudt, Kathrin K Geyer, Gilda Padalino, Karl F Hoffmann, Nancy Holroyd, Matt Berriman, Benoît Aliaga, Cristian Chaparro, Christoph Grunau, Ronaldo de Carvalho Augusto

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The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets. by Kezia C L Whatley, Gilda Padalino, Helen Whiteland, Kathrin K Geyer, Benjamin J Hulme, Iain W Chalmers, Josephine Forde-Thomas, Salvatore Ferla, Andrea Brancale, Karl F Hoffmann

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Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae. by Thomas A Gasan, Marije E Kuipers, Grisial H Roberts, Gilda Padalino, Josephine E Forde-Thomas, Shona Wilson, Jakub Wawrzyniak, Edridah M Tukahebwa, Karl F Hoffmann, Iain W Chalmers

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Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment. by Iain W Chalmers, Colin M Fitzsimmons, Martha Brown, Christine Pierrot, Frances M Jones, Jakub M Wawrzyniak, Narcis Fernandez-Fuentes, Edridah M Tukahebwa, David W Dunne, Jamal Khalife, Karl F Hoffmann

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Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes [version 1; peer review: 2 approved] by Iain W. Chalmers, Christoph Grunau, Josephine Forde-Thomas, Karl F. Hoffmann, Andrea Brancale, Cassandra A. Celatka, Gilda Padalino, Jay H. Kalin, Hugh Y. Rienhoff Jr., Damien Lassalle, Philip A. Cole

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An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistoso... by Helen L. Whiteland, Anand Chakroborty, Josephine E. Forde-Thomas, Alessandra Crusco, Alan Cookson, Jackie Hollinshead, Caroline A. Fenn, Barbara Bartholomew, Peter A. Holdsworth, Maggie Fisher, Robert J. Nash, Karl F. Hoffmann

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Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7. by Natalie Reimers, Arne Homann, Beate Höschler, Kristina Langhans, R Alan Wilson, Christine Pierrot, Jamal Khalife, Christoph G Grevelding, Iain W Chalmers, Maria Yazdanbakhsh, Karl F Hoffmann, Cornelis H Hokke, Helmut Haas, Gabriele Schramm

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The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with... by Kathrin K Geyer, Umar H Niazi, David Duval, Céline Cosseau, Chad Tomlinson, Iain W Chalmers, Martin T Swain, David J Cutress, Utibe Bickham-Wright, Sabrina E Munshi, Christoph Grunau, Timothy P Yoshino, Karl F Hoffmann

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