Design considerations for early-phase clinical trials of immune-oncology agents by Nolan A. Wages, Cody Chiuzan, Katherine S. Panageas

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The Emotional Intelligence, Occupational Stress, and Coping Characteristics by Years of Nursing Experiences of Newly Hired Oncology Nurses by Ann M Mazzella-Ebstein, Kay See Tan, Katherine S Panageas, Judith E Arnetz, Margaret Barton-Burke

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128 staRgate: a flexible density-based automated gating pipeline for complex high-dimensional flow cytometry data by Matthew Adamow, Katherine S Panageas, Phillip Wong, Margaret K Callahan, Ronglai Shen, Fiona Ehrich, Colleen Maher, Jasme Lee, Xiyu Peng

Risks and benefits of reinduction ipilimumab/nivolumab in melanoma patients previously treated with ipilimumab/nivolumab by Alexander N Shoushtari, Katherine S Panageas, Jedd D Wolchok, Paul B Chapman, Margaret Callahan, Allison Betof Warner, Vetri Sudar Jayaprakasam

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Neutrophil to Lymphocyte Ratio is Associated With Outcome During Ipilimumab Treatment by Michael R. Cassidy, Rachel E. Wolchok, Junting Zheng, Katherine S. Panageas, Jedd D. Wolchok, Daniel Coit, Michael A. Postow, Charlotte Ariyan

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Assessment of variation in 30‐day mortality following cancer surgeries among older adults across US hospitals by Allison Lipitz‐Snyderman, Jessica A. Lavery, Peter B. Bach, Diane G. Li, Annie Yang, Vivian E. Strong, Ashley Russo, Katherine S. Panageas

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Addressing racial and ethnic disparities in AACR project GENIE by Shawn M. Sweeney, Jessica A. Lavery, Hannah E. Fuchs, Jocelyn A. Lee, Samantha Brown, Katherine S. Panageas, Charles L. Sawyers, Philippe L. Bedard

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135 Integration of T-cell activation and tumor mutation burden predicts anti-PD-1 response by Matthew Adamow, Katherine S Panageas, Michael Postow, Margaret K Callahan, James W Smithy, Ronglai Shen, Fiona Ehrich, Colleen Maher, Jasme Lee, Xiyu Peng, Samuel A Funt, Niamh Keegan

221 Digital assessment of stromal B cell aggregates as a biomarker of response to immune checkpoint inhibition in unresectable melanoma by Katherine S Panageas, Yanyun Li, Margaret K Callahan, James W Smithy, Andrea P Moy, Ronglai Shen, Fiona Ehrich, Colleen Maher, Jasme Lee, Xiyu Peng, Nathaniel Aleynick, Mingqiang Zhuang, Travis Hollmann

1303 Spatial topic modeling of tumor microenvironment with multiplexed imaging by Katherine S Panageas, Yanyun Li, Margaret K Callahan, James W Smithy, Andrea P Moy, Ronglai Shen, Fiona Ehrich, Colleen Maher, Jasme Lee, Xiyu Peng, Nathaniel Aleynick, Mingqiang Zhuang, Travis Hollmann

Challenges and positive impact of rare cancer caregiving: A mixed-methods study of caregivers of patients with Erdheim-Chester disease and other histiocytic neoplasms by Hannah-Rose Mitchell, Allison J. Applebaum, Kathleen A. Lynch, Anne S. Reiner, Thomas M. Atkinson, Justin J. Buthorn, Allison S. Sigler, Dana Bossert, Kathleen Brewer, Jessica Corkran, Deanna Fournier, Katherine S. Panageas, Eli L. Diamond

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Peripheral blood clinical laboratory variables associated with outcomes following combination nivolumab and ipilimumab immunotherapy in melanoma by Samuel Rosner, Erica Kwong, Alexander N. Shoushtari, Claire F. Friedman, Allison S. Betof, Mary Sue Brady, Daniel G. Coit, Margaret K. Callahan, Jedd D. Wolchok, Paul B. Chapman, Katherine S. Panageas, Michael A. Postow

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Phase I clinical trial of temsirolimus and perifosine for recurrent glioblastoma by Thomas J. Kaley, Katherine S. Panageas, Elena I. Pentsova, Ingo K. Mellinghoff, Craig Nolan, Igor Gavrilovic, Lisa M. DeAngelis, Lauren E. Abrey, Eric C. Holland, Antonio Omuro, Mario E. Lacouture, Emmy Ludwig, Andrew B. Lassman

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Ipilimumab alone or in combination with nivolumab in patients with advanced melanoma who have progressed or relapsed on PD-1 blockade: clinical outcomes and translational biomarker... by Antoni Ribas, Paul Chapman, Katherine S Panageas, Michael Postow, Joyson Karakunnel, Hussein Tawbi, Christine Spencer, Katy Tsai, Ramy Ibrahim, Jedd Wolchok, Theresa LaVallee, Travis J Hollmann, Alexander Shoushtari, Daniel K Wells, Margaret Callahan, Samantha Bucktrout, Claire F Friedman, Christopher R Cabanski, Pier Gherardini, Richard O Chen

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Intracranial Outcomes of De Novo Brain Metastases Treated With Osimertinib Alone in Patients With Newly Diagnosed EGFR-Mutant NSCLC by Brandon S. Imber, MD, MA, Ryka Sehgal, MD, Rachel Saganty, MD, Anne S. Reiner, MPH, A. Turan Ilica, MD, Emily Miao, PharmD, Bob T. Li, MD, Gregory J. Riely, MD, Helena A. Yu, MD, Katherine S. Panageas, DrPH, Robert J. Young, MD, Luke R.G. Pike, MD, DPhil, Nelson S. Moss, MD

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Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade by Arnab Ghosh, Judith Michels, Riccardo Mezzadra, Divya Venkatesh, Lauren Dong, Ricardo Gomez, Fadi Samaan, Yu-Jui Ho, Luis Felipe Campesato, Levi Mangarin, John Fak, Nathan Suek, Aliya Holland, Cailian Liu, Mohsen Abu-Akeel, Yonina Bykov, Hong Zhong, Kelly Fitzgerald, Sadna Budhu, Andrew Chow, Roberta Zappasodi, Katherine S. Panageas, Olivier de Henau, Marcus Ruscetti, Scott W. Lowe, Taha Merghoub, Jedd D. Wolchok

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878 T cell immunotherapies recruit and activate neutrophils to eliminate tumor antigen escape variants by David Ng, Katherine S Panageas, Jedd D Wolchok, Taha Merghoub, Sadna Budhu, Olivier De Henau, Yanyun Li, Billel Gasmi, Cailian Liu, Sara Schad, Rebekka Duhen, Andrew D Weinberg, Mathieu Gigoux, David Redmond, David Schroder, Andrew Chow, Daniel Hirschhorn, Lukas kraehenbuehl, Isabell Schulze, Aliya Holland, Jean Albrengues, Mikala Egeblad, Arshi Arora, Xue-Yan He, Linda Hamadene, Travis Hollmann, Jacob M Ricca, Levi Mark B Mangarin, Anne-Laure Flamar, Heyjin Choi, Czrina A Cortez, Allison Betof Warner, Gabrielle A Rizzuto, Christine N Spencer