Characterization of rare histological subtypes of ovarian cancer based on molecular profiling by Nobutaka Takahashi, Keiichi Hatakeyama, Takeshi Nagashima, Keiichi Ohshima, Kenichi Urakami, Ken Yamaguchi, Yasuyuki Hirashima

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A Fragrant Environment Containing α-Pinene Suppresses Tumor Growth in Mice by Modulating the Hypothalamus/Sympathetic Nerve/Leptin Axis and Immune System by Masatoshi Kusuhara MD, Koji Maruyama PhD, Hidee Ishii, Yoko Masuda, Kazutoshi Sakurai PhD, Eiko Tamai, Kenichi Urakami PhD

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Metachronous ovarian endometrioid carcinomas in a patient with a PTEN variant: case report of incidentally detected Cowden syndrome by Hiroyuki Matsubayashi, Satomi Higashigawa, Yoshimi Kiyozumi, Yasue Horiuchi, Yasuyuki Hirashima, Nobuhiro Kado, Masato Abe, Takuma Ohishi, Sumiko Ohnami, Kenichi Urakami, Ken Yamaguchi

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Report of two patients in whom comparisons of the somatic mutation profile were useful for the diagnosis of metastatic tumors by Kenichiro Furukawa, Keiichi Hatakeyama, Masanori Terashima, Keiichi Fujiya, Yutaka Tanizawa, Etsuro Bando, Takashi Sugino, Kenichi Urakami, Tateaki Naito, Hiroyasu Kagawa, Ken Yamaguchi

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Germline mismatch repair gene variants analyzed by universal sequencing in Japanese cancer patients by Yoshimi Kiyozumi, Hiroyuki Matsubayashi, Yasue Horiuchi, Satomi Higashigawa, Takuma Oishi, Masato Abe, Sumiko Ohnami, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Hidehiko Miyake, Ken Yamaguchi

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Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene by Hitoshi Hino, Akio Shiomi, Masatoshi Kusuhara, Hiroyasu Kagawa, Yushi Yamakawa, Keiichi Hatakeyama, Takanori Kawabata, Takuma Oishi, Kenichi Urakami, Takeshi Nagashima, Yusuke Kinugasa, Ken Yamaguchi

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Tumor cell enrichment by tissue suspension enables detection of mutations with low variant allele frequency and estimation of germline mutations by Keiichi Hatakeyama, Koji Muramatsu, Takeshi Nagashima, Yuichi Kawanishi, Ryutaro Fukumura, Keiichi Ohshima, Yuji Shimoda, Hirotsugu Kenmotsu, Tohru Mochizuki, Kenichi Urakami, Yasuto Akiyama, Takashi Sugino, Ken Yamaguchi

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Characterization of pancreatic cancer with ultra-low tumor mutational burden by Taisuke Imamura, Ryo Ashida, Keiichi Ohshima, Katsuhiko Uesaka, Teiichi Sugiura, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Keiichi Hatakeyama, Takeshi Nagashima, Takashi Sugino, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi

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Two Japanese families with familial pancreatic cancer with suspected pathogenic variants of CDKN2A: a case report by Yoshimi Kiyozumi, Hiroyuki Matsubayashi, Akiko Todaka, Ryo Ashida, Seiichiro Nishimura, Nobuhiro Kado, Satomi Higashigawa, Rina Harada, Eiko Ishihara, Yasue Horiuchi, Goichi Honda, Hirotsugu Kenmotsu, Masakuni Serizawa, Kenichi Urakami

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JCGA: the Japanese version of the Cancer Genome Atlas and its contribution to the interpretation of gene alterations detected in clinical cancer genome sequencing by Masakuni Serizawa, Maki Mizuguchi, Kenichi Urakami, Takeshi Nagashima, Keiichi Ohshima, Keiichi Hatakeyama, Sumiko Ohnami, Shumpei Ohnami, Koji Maruyama, Tadashi Ashizawa, Akira Iizuka, Yasue Horiuchi, Akane Naruoka, Hirotsugu Kenmotsu, Yasuto Akiyama, Ken Yamaguchi

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Tumor cell enrichment by tissue suspension improves sensitivity to copy number variation in diffuse gastric cancer with low tumor content by Keiichi Hatakeyama, Koji Muramatsu, Takeshi Nagashima, Hiroyuki Ichida, Yuichi Kawanishi, Ryutaro Fukumura, Keiichi Ohshima, Yuji Shimoda, Sumiko Ohnami, Shumpei Ohnami, Koji Maruyama, Akane Naruoka, Hirotsugu Kenmotsu, Kenichi Urakami, Yasuto Akiyama, Takashi Sugino, Ken Yamaguchi

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Overview and clinical significance of multiple mutations in individual genes in hepatocellular carcinoma by Taisuke Imamura, Yukiyasu Okamura, Keiichi Ohshima, Katsuhiko Uesaka, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhisa Ohgi, Shimpei Otsuka, Sumiko Ohnami, Takeshi Nagashima, Keiichi Hatakeyama, Takashi Sugino, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi

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Hepatocellular carcinoma after a sustained virological response by direct‐acting antivirals harbors TP53 inactivation by Taisuke Imamura, Yukiyasu Okamura, Keiichi Ohshima, Katsuhiko Uesaka, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhisa Ohgi, Shimpei Otsuka, Sumiko Ohnami, Takeshi Nagashima, Keiichi Hatakeyama, Yuko Kakuda, Takashi Sugino, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi

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Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors by Keiichi Ohshima, Keiichi Hatakeyama, Takeshi Nagashima, Yuko Watanabe, Kaori Kanto, Yuki Doi, Tomomi Ide, Yuji Shimoda, Tomoe Tanabe, Sumiko Ohnami, Shumpei Ohnami, Masakuni Serizawa, Koji Maruyama, Yasuto Akiyama, Kenichi Urakami, Masatoshi Kusuhara, Tohru Mochizuki, Ken Yamaguchi

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Comparison of genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma in Japanese patients using a novel panel for cancer-related drug-metabolizing enzyme genes by Sumiko Ohnami, Akane Naruoka, Mitsuhiro Isaka, Maki Mizuguchi, Sou Nakatani, Fukumi Kamada, Yuji Shimoda, Ai Sakai, Keiichi Ohshima, Keiichi Hatakeyama, Kouji Maruyama, Yasuhisa Ohde, Hirotsugu Kenmotsu, Toshiaki Takahashi, Yasuto Akiyama, Takeshi Nagashima, Kenichi Urakami, Shumpei Ohnami, Ken Yamaguchi

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Metabolic Profiling of Human Gastric Cancer Cells Treated With Salazosulfapyridine by Kohei Takizawa MD, Koji Muramatsu PA, Kouji Maruyama PhD, Kenichi Urakami MD, PhD, Takashi Sugino MD, PhD, Masatoshi Kusuhara MD, PhD, Ken Yamaguchi MD, PhD, Hiroyuki Ono MD, PhD, Yuko Kitagawa MD, PhD

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Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to wh... by Akira Ono, Yukihiro Terada, Takuya Kawata, Masakuni Serizawa, Mitsuhiro Isaka, Takanori Kawabata, Toru Imai, Keita Mori, Koji Muramatsu, Isamu Hayashi, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Yasuhisa Ohde, Ken Yamaguchi, Toshiaki Takahashi

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Molecular genetic positioning of small intestine and papilla of Vater carcinomas including clinicopathological classification by Masanori Nakamura, Yukiyasu Okamura, Keiichi Ohshima, Teiichi Sugiura, Ryo Ashida, Katsuhisa Ohgi, Etsuro Bando, Keiichi Fujiya, Akio Shiomi, Hiroyasu Kagawa, Taisuke Imamura, Goro Nakayama, Yasuhiro Kodera, Katsuhiko Uesaka, Nobuyuki Ohike, Tomoko Norose, Keiko Sasaki, Takashi Sugino, Sumiko Ohnami, Takeshi Nagashima, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi

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Evaluation of whole genome sequencing utility in identifying driver alterations in cancer genome by Takeshi Nagashima, Ken Yamaguchi, Kenichi Urakami, Yuji Shimoda, Sumiko Ohnami, Keiichi Ohshima, Tomoe Tanabe, Akane Naruoka, Fukumi Kamada, Masakuni Serizawa, Keiichi Hatakeyama, Shumpei Ohnami, Koji Maruyama, Tohru Mochizuki, Maki Mizuguchi, Akio Shiomi, Yasuhisa Ohde, Etsuro Bando, Teiichi Sugiura, Takashi Mukaigawa, Seiichiro Nishimura, Yasuyuki Hirashima, Koichi Mitsuya, Shusuke Yoshikawa, Yoshio Kiyohara, Yasuhiro Tsubosa, Hirohisa Katagiri, Masashi Niwakawa, Kaoru Takahashi, Hiroya Kashiwagi, Yoshichika Yasunaga, Yuji Ishida, Takashi Sugino, Hirotsugu Kenmotsu, Masanori Terashima, Mitsuru Takahashi, Katsuhiko Uesaka, Yasuto Akiyama

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