Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin by Seok-Hyung Kim, Christina K. Speirs, Lilianna Solnica-Krezel, Kevin C. Ess

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Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin by Robert P. Carson, Dominic L. Van Nielen, Peggy A. Winzenburger, Kevin C. Ess

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Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish by Seok-Hyung Kim, Marie L. Kowalski, Robert P. Carson, L. Richard Bridges, Kevin C. Ess

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Reproducible and efficient generation of functionally active neurons from human hiPSCs for preclinical disease modeling by Yunyao Xie, Ryan J. Schutte, Nathan N. Ng, Kevin C. Ess, Philip H. Schwartz, Diane K. O'Dowd

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A rare cause of posterior reversible encephalopathy syndrome: Acute lymphoblastic leukemia by Jessica Hayes, Anne Byrd Mahoney, Claci Ayers, Asha Sarma, Kevin C. Ess, Tracy E. Hunley, Christine Moore Smith

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Multi-organ abnormalities and mTORC1 activation in zebrafish model of multiple acyl-CoA dehydrogenase deficiency. by Seok-Hyung Kim, Sarah A Scott, Michael J Bennett, Robert P Carson, Joshua Fessel, H Alex Brown, Kevin C Ess

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Non-canonical functions of a mutant TSC2 protein in mitotic division. by Mary-Bronwen L Chalkley, Rachel B Mersfelder, Maria Sundberg, Laura C Armstrong, Mustafa Sahin, Rebecca A Ihrie, Kevin C Ess

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Gammaretroviral vector encoding a fluorescent marker to facilitate detection of reprogrammed human fibroblasts during iPSC generation by Narasimhachar Srinivasakumar, Michail Zaboikin, Andrew M. Tidball, Asad A. Aboud, M. Diana Neely, Kevin C. Ess, Aaron B. Bowman, Friedrich G. Schuening

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Neuronal modeling of alternating hemiplegia of childhood reveals transcriptional compensation and replicates a trigger-induced phenotype by John P. Snow, Grant Westlake, Lindsay K. Klofas, Soyoun Jeon, Laura C. Armstrong, Kathryn J. Swoboda, Alfred L. George, Jr, Kevin C. Ess

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Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapam... by Veniamin Y. Sidorov, Tatiana N. Sidorova, Philip C. Samson, Ronald S. Reiserer, Clayton M. Britt, M. Diana Neely, Kevin C. Ess, John P. Wikswo

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Comparisons of dual isogenic human iPSC pairs identify functional alterations directly caused by an epilepsy associated SCN1A mutation by Yunyao Xie, Nathan N. Ng, Olga S. Safrina, Carmen M. Ramos, Kevin C. Ess, Philip H. Schwartz, Martin A. Smith, Diane K. O'Dowd

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Cerebral aquaporin-4 expression is independent of seizures in tuberous sclerosis complex by Brittany Short, Lindsay Kozek, Hannah Harmsen, Bo Zhang, Michael Wong, Kevin C. Ess, Cary Fu, Robert Naftel, Matthew M. Pearson, Robert P. Carson

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DEPDC5 haploinsufficiency drives increased mTORC1 signaling and abnormal morphology in human iPSC-derived cortical neurons by Lindsay K. Klofas, Brittany P. Short, John P. Snow, Justine Sinnaeve, Gabrielle V. Rushing, Grant Westlake, Will Weinstein, Rebecca A. Ihrie, Kevin C. Ess, Robert P. Carson

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Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells. by Andrew M Tidball, M Diana Neely, Reed Chamberlin, Asad A Aboud, Kevin K Kumar, Bingying Han, Miles R Bryan, Michael Aschner, Kevin C Ess, Aaron B Bowman

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Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination. by Mark D Grier, Kathryn L West, Nathaniel D Kelm, Cary Fu, Mark D Does, Brittany Parker, Eleanor McBrier, Andre H Lagrange, Kevin C Ess, Robert P Carson

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A Simplified, Fully Defined Differentiation Scheme for Producing Blood-Brain Barrier Endothelial Cells from Human iPSCs by Emma H. Neal, Nicholas A. Marinelli, Yajuan Shi, P. Mason McClatchey, Kylie M. Balotin, Dalton R. Gullett, Kameron A. Hagerla, Aaron B. Bowman, Kevin C. Ess, John P. Wikswo, Ethan S. Lippmann

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A post-developmental genetic screen for zebrafish models of inherited liver disease. by Seok-Hyung Kim, Shu-Yu Wu, Jeong-In Baek, Soo Young Choi, Yanhui Su, Charles R Flynn, Joshua T Gamse, Kevin C Ess, Gary Hardiman, Joshua H Lipschutz, Naji N Abumrad, Don C Rockey

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Genomic, transcriptomic, and metabolomic profiles of hiPSC-derived dopamine neurons from clinically discordant brothers with identical PRKN deletions by Holly N. Cukier, Hyunjin Kim, Anthony J. Griswold, Simona G. Codreanu, Lisa M. Prince, Stacy D. Sherrod, John A. McLean, Derek M. Dykxhoorn, Kevin C. Ess, Peter Hedera, Aaron B. Bowman, M. Diana Neely

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Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis. by Yeliz Boglev, Andrew P Badrock, Andrew J Trotter, Qian Du, Elsbeth J Richardson, Adam C Parslow, Sebastian J Markmiller, Nathan E Hall, Tanya A de Jong-Curtain, Annie Y Ng, Heather Verkade, Elke A Ober, Holly A Field, Donghun Shin, Chong H Shin, Katherine M Hannan, Ross D Hannan, Richard B Pearson, Seok-Hyung Kim, Kevin C Ess, Graham J Lieschke, Didier Y R Stainier, Joan K Heath

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