Interval estimation of the overall treatment effect in a meta-analysis of a few small studies with zero events by Konstantinos Pateras, Stavros Nikolakopoulos, Dimitris Mavridis, Kit C.B. Roes

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Evaluation of gene expression classification studies: factors associated with classification performance. by Putri W Novianti, Kit C B Roes, Marinus J C Eijkemans

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The Trial within Cohorts (TwiCs) study design in oncology: experience and methodological reflections by Rob Kessels, Anne M. May, Miriam Koopman, Kit C. B. Roes

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Subgroup analyses in confirmatory clinical trials: time to be specific about their purposes by Julien Tanniou, Ingeborg van der Tweel, Steven Teerenstra, Kit C. B. Roes

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Meta-analysis approach as a gene selection method in class prediction: does it improve model performance? A case study in acute myeloid leukemia by Putri W. Novianti, Victor L. Jong, Kit C. B. Roes, Marinus J. C. Eijkemans

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Towards an appropriate framework to facilitate responsible inclusion of pregnant women in drug development programs by Kit C. B. Roes, Indira S. E. van der Zande, Maarten van Smeden, Rieke van der Graaf

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An Application of Sequential Meta-Analysis to Gene Expression Studies by Putri W. Novianti, Ingeborg van der Tweel, Victor L. Jong, Kit C. B. Roes, Marinus J. C. Eijkemans

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Room for improvement in conducting and reporting non-inferiority randomized controlled trials on drugs: a systematic review. by Grace Wangge, Olaf H Klungel, Kit C B Roes, Anthonius de Boer, Arno W Hoes, Mirjam J Knol

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Predicting enrollment performance of investigational centers in phase III multi-center clinical trials by Rutger M. van den Bor, Diederick E. Grobbee, Bas J. Oosterman, Petrus W.J. Vaessen, Kit C.B. Roes

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In-silico trial of intracranial flow diverters replicates and expands insights from conventional clinical trials by Ali Sarrami-Foroushani, Toni Lassila, Michael MacRaild, Joshua Asquith, Kit C. B. Roes, James V. Byrne, Alejandro F. Frangi

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In silico cancer immunotherapy trials uncover the consequences of therapy-specific response patterns for clinical trial design and outcome by Jeroen H. A. Creemers, Ankur Ankan, Kit C. B. Roes, Gijs Schröder, Niven Mehra, Carl G. Figdor, I. Jolanda M. de Vries, Johannes Textor

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The STEPWISE study: study protocol for a smartphone-based exercise solution for people with Parkinson’s Disease (randomized controlled trial) by Sabine Schootemeijer, Nienke M. de Vries, Eric A. Macklin, Kit C.B. Roes, Hilde Joosten, Larsson Omberg, Alberto Ascherio, Michael A. Schwarzschild, Bastiaan R. Bloem

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Multiple N-of-1 trials to investigate hypoxia therapy in Parkinson’s disease: study rationale and protocol by Jules M. Janssen Daalen, Marjan J. Meinders, Federica Giardina, Kit C. B. Roes, Bas C. Stunnenberg, Soania Mathur, Philip N. Ainslie, Dick H. J. Thijssen, Bastiaan R. Bloem

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Rare disease registries: potential applications towards impact on development of new drug treatments by Marijke C. Jansen-van der Weide, Charlotte M. W. Gaasterland, Kit C. B. Roes, Caridad Pontes, Roser Vives, Arantxa Sancho, Stavros Nikolakopoulos, Eric Vermeulen, Johanna H. van der Lee

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Applicability and added value of novel methods to improve drug development in rare diseases by Marian Mitroiu, Katrien Oude Rengerink, Caridad Pontes, Aranzazu Sancho, Roser Vives, Stella Pesiou, Juan Manuel Fontanet, Ferran Torres, Stavros Nikolakopoulos, Konstantinos Pateras, Gerd Rosenkranz, Martin Posch, Susanne Urach, Robin Ristl, Armin Koch, Spineli Loukia, Johanna H. van der Lee, Kit C. B. Roes

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A Road Map for Remote Digital Health Technology for Motor Neuron Disease by Ruben P A van Eijk, Anita Beelen, Esther T Kruitwagen, Deirdre Murray, Ratko Radakovic, Esther Hobson, Liam Knox, Jochem Helleman, Tom Burke, Miguel Ángel Rubio Pérez, Evy Reviers, Angela Genge, Frederik J Steyn, Shyuan Ngo, John Eaglesham, Kit C B Roes, Leonard H van den Berg, Orla Hardiman, Christopher J McDermott

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Lithium carbonate in amyotrophic lateral sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A: protocol for a confirmatory, randomized, group-sequential, even... by Sean W. Willemse, Kit C. B. Roes, Philip Van Damme, Orla Hardiman, Caroline Ingre, Monica Povedano, Naomi R. Wray, Marleen Gijzen, Mirjam S. de Pagter, Koen C. Demaegd, Annemarie F. C. Janse, Roel G. Vink, Boudewijn T. H. M. Sleutjes, Adriano Chiò, Philippe Corcia, Evy Reviers, Ammar Al-Chalabi, Matthew C. Kiernan, Leonard H. van den Berg, Michael A. van Es, Ruben P. A. van Eijk

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