CD8+ regulatory T cells, and not CD4+ T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells. by Mardi C Boer, Krista E van Meijgaarden, Simone A Joosten, Tom H M Ottenhoff

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C-Terminal PEGylation Improves SAAP-148 Peptide’s Immunomodulatory Activities by Miriam E. van Gent, Bep Schonkeren-Ravensbergen, Asma Achkif, Daan Beentjes, Natasja Dolezal, Krista E. van Meijgaarden, Jan Wouter Drijfhout, Peter H. Nibbering

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Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment. by Simone A Joosten, Krista E van Meijgaarden, Franca Del Nonno, Andrea Baiocchini, Linda Petrone, Valentina Vanini, Hermelijn H Smits, Fabrizio Palmieri, Delia Goletti, Tom H M Ottenhoff

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Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies... by Krista E van Meijgaarden, Bhagwati Khatri, Steven G Smith, Anne M F H Drittij, Roelof A de Paus, Jelle J Goeman, Mei M Ho, Hazel M Dockrell, Helen McShane, Simone A Joosten, Tom H M Ottenhoff

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Longitudinal soluble marker profiles reveal strong association between cytokine storms resulting from macrophage activation and disease severity in COVID-19 disease by Krista E. van Meijgaarden, Suzanne van Veen, Roula Tsonaka, Paula Ruibal, Anna H. E. Roukens, Sesmu M. Arbous, Judith Manniën, Suzanne C. Cannegieter, Tom H. M. Ottenhoff, Simone A. Joosten, BEAT-COVID group, COVID-19 LUMC group

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BCG revaccination in adults enhances pro-inflammatory markers of trained immunity along with anti-inflammatory pathways by Asma Ahmed, Himanshu Tripathi, Krista E. van Meijgaarden, Nirutha Chetan Kumar, Vasista Adiga, Srabanti Rakshit, Chaitra Parthiban, Sharon Eveline J, George D’Souza, Mary Dias, Tom H.M. Ottenhoff, Mihai G. Netea, Simone A. Joosten, Annapurna Vyakarnam

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Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method. by Susanna Commandeur, Mariateresa Coppola, Karin Dijkman, Annemieke H Friggen, Krista E van Meijgaarden, Susan J F van den Eeden, Louis Wilson, Jolien J van der Ploeg-van Schip, Kees L M C Franken, Annemieke Geluk, Tom H M Ottenhoff

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HLA-E/Mtb specific CD4+ and CD8+ T cells have a memory phenotype in individuals with TB infection by Linda Voogd, Catherine Riou, Catherine Riou, Thomas J. Scriba, Marjolein van Wolfswinkel, Krista E. van Meijgaarden, Kees L. M. C. Franken, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Robert J. Wilkinson, Tom H. M. Ottenhoff, Simone A. Joosten

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BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination by Krista E. van Meijgaarden, Wenchao Li, Simone J. C. F. M. Moorlag, Valerie A. C. M. Koeken, Hans J. P. M. Koenen, Leo A. B. Joosten, Annapurna Vyakarnam, Asma Ahmed, Srabanti Rakshit, Vasista Adiga, Tom H. M. Ottenhoff, Yang Li, Mihai G. Netea, Simone A. Joosten

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<em>Mtb</em>-Specific HLA-E-Restricted T Cells Are Induced during <em>Mtb</em> Infection but Not after BCG Administration in Non-Human Primates and Humans by Linda Voogd, Marjolein van Wolfswinkel, Iman Satti, Andrew D. White, Karin Dijkman, Anele Gela, Krista E. van Meijgaarden, Kees L. M. C. Franken, Julia L. Marshall, Tom H. M. Ottenhoff, Thomas J. Scriba, Helen McShane, Sally A. Sharpe, Frank A. W. Verreck, Simone A. Joosten

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Identification of circulating monocytes as producers of tuberculosis disease biomarker C1q by Paula Niewold, Douwe J. Dijkstra, Yi Cai, Delia Goletti, Fabrizio Palmieri, Krista E. van Meijgaarden, Frank A. W. Verreck, Onno W. Akkerman, Regina W. Hofland, Eveline M. Delemarre, Stefan Nierkens, Marije K. Verheul, Andrew J. Pollard, Jaap T. van Dissel, Tom H. M. Ottenhoff, Leendert A. Trouw, Simone A. Joosten

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Mtb HLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire by Linda Voogd, Anne M.H.F. Drittij, Calinda K.E. Dingenouts, Kees L.M.C. Franken, Vincent van Unen, Krista E. van Meijgaarden, Paula Ruibal, Renate S. Hagedoorn, Judith A. Leitner, Peter Steinberger, Mirjam H.M. Heemskerk, Mark M. Davis, Thomas J. Scriba, Tom H.M. Ottenhoff, Simone A. Joosten

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A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity by Wenchao Li, Simone J.C.F.M. Moorlag, Valerie A.C.M. Koeken, Rutger J. Röring, L. Charlotte J. de Bree, Vera P. Mourits, Manoj K. Gupta, Bowen Zhang, Jianbo Fu, Zhenhua Zhang, Inge Grondman, Krista E. van Meijgaarden, Liang Zhou, Ahmed Alaswad, Leo A.B. Joosten, Reinout van Crevel, Cheng-Jian Xu, Mihai G. Netea, Yang Li

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Immune Determinants of Viral Clearance in Hospitalised COVID-19 Patients: Reduced Circulating Naïve CD4+ T Cell Counts Correspond with Delayed Viral Clearance by Mihaela Zlei, Igor A. Sidorov, Simone A. Joosten, Mirjam H. M. Heemskerk, Sebenzile K. Myeni, Cilia R. Pothast, Caroline S. de Brouwer, A. Linda Boomaars-van der Zanden, Krista E. van Meijgaarden, Shessy T. Morales, Els Wessels, Jacqueline J. Janse, Jelle J. Goeman, Christa M. Cobbaert, Aloys C. M. Kroes, Suzanne C. Cannegieter, Meta Roestenberg, Leonardus G. Visser, Marjolein Kikkert, Mariet C. W. Feltkamp, Sesmu M. Arbous, Frank J. T. Staal, Tom H. M. Ottenhoff, Jacques J. M. van Dongen, Anna H. E. Roukens, Jutte J. C. de Vries, in collaboration with BEAT-COVID, in collaboration with LUMC COVID

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Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults by Srabanti Rakshit, Srabanti Rakshit, Vasista Adiga, Vasista Adiga, Vasista Adiga, Asma Ahmed, Asma Ahmed, Chaitra Parthiban, Chaitra Parthiban, Nirutha Chetan Kumar, Nirutha Chetan Kumar, Pratibha Dwarkanath, Sudarshan Shivalingaiah, Srishti Rao, George D’Souza, Mary Dias, Thomas J. A. Maguire, Katie J. Doores, Martijn Zoodsma, Martijn Zoodsma, Busranur Geckin, Prokar Dasgupta, Sudhir Babji, Krista E. van Meijgaarden, Simone A. Joosten, Tom H. M. Ottenhoff, Yang Li, Yang Li, Mihai G. Netea, Kenneth D. Stuart, Stephen C. De Rosa, M. Juliana McElrath, M. Juliana McElrath, Annapurna Vyakarnam, Annapurna Vyakarnam, Annapurna Vyakarnam

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Host biomarker-based quantitative rapid tests for detection and treatment monitoring of tuberculosis and COVID-19 by Louise Pierneef, Anouk van Hooij, Danielle de Jong, Elisa M. Tjon Kon Fat, Krista E. van Meijgaarden, Elisa Petruccioli, Valentina Vanini, Anna H.E. Roukens, Delia Goletti, Paul L.A.M. Corstjens, Simone A. Joosten, Annemieke Geluk, M.S. Arbous, B.M. van den Berg, S. Cannegieter, C.M. Cobbaert, A. van der Does, J.J.M. van Dongen, J. Eikenboom, M.C.M. Feltkamp, A. Geluk, J.J. Goeman, M. Giera, T. Hankemeier, M.H.M. Heemskerk, P.S. Hiemstra, C.H. Hokke, J.J. Janse, S.P. Jochems, S.A. Joosten, M. Kikkert, L. Lamont, J. Manniën, T.H.M. Ottenhoff, M.R. del Prado, N. Queralt Rosinach, M. Roestenberg, M. Roos, A.H.E. Roukens, H.H. Smits, E.J. Snijder, F.J.T. Staal, L.A. Trouw, R. Tsonaka, A. Verhoeven, L.G. Visser, J.J.C. de Vries, D.J. van Westerloo, J. Wigbers, H.J. van der Wijk, R.C. van Wissen, M. Wuhrer, M. Yazdanbakhsh, M. Zlei

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