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1074 PK/RO modeling of WTX-124, a tumor-activated IL-2 prodrug, highlights the potential for a substantially improved therapeutic index compared to other IL-2 molecules by Christopher J Nirschl, Kyriakos Economides, Kristin Morris, Andres Salmeron, Daniel J Hicklin, Cynthia Seidel-Dugan, Kulandayan K Subramanian, Randi Isaacs, Sameer Chopra, Celesztina Domonkos
Published 2023-11-01Article -
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737 A phase 1/1b study of the tumor-activated IL-2 prodrug WTX-124 alone or in combination with pembrolizumab in patients with immunotherapy-sensitive locally advanced or metastati... by Brendan Curti, Igor Puzanov, Mateusz Opyrchal, Christopher J Nirschl, Mehmet A Bilen, Kristin Morris, Justin C Moser, Ildefonso Rodriguez Rivera, Saero Park, Marissa Bruno, Paul Windt, Kulandayan K Subramanian, Sameer S Chopra, Randi Isaacs
Published 2023-11-01Article