BISPHOSPHONATES AFFECT HUMAN OSTEOCLAST DEVELOPMENT IN VITRO di Mabilleau, G, Kwaasi, A, Sabokbar, A, Tsoumpra, M, Ebetino, F, Russell, R

Alendronate and ibandronate affect osteoclast formation and size differently from risedronate and zoledronate di Mabilleau, G, Kwaasi, A, Tsoumpra, M, Sabokbar, A, Dunford, J, Ebetino, F, Russell, R

Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 23... di Tsoumpra, M, Barnett, B, Kwaasi, A, Walters, R, Ebetino, F, Russell, R, Oppermann, U, Dunford, J

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate syntha... di Dunford, J, Kwaasi, A, Rogers, M, Barnett, B, Ebetino, F, Russell, R, Oppermann, U, Kavanagh, K

Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase di Dunford, J, Kwaasi, A, Kavanagh, K, Rogers, M, Oppermann, U, Barnett, B, Ebetino, F, Graham, R, Russell, G

The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates di Dunford, J, Pilka, E, Kwaasi, A, Evdokimov, A, Barnett, B, Oppermann, U, Ebetino, F, Russell, R, Kavanagh, K

Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate... di Dunford, J, Pilka, E, Kwaasi, A, Evdokimov, A, Barnett, B, Oppermann, U, Ebetino, F, Russell, R, Kavanagh, K

The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates di Dunford, J, Pilka, E, Kwaasi, A, Evdokimov, A, Barnett, B, Oppermann, U, Ebetino, F, Graham, R, Russell, G, Kavanagh, K

The Successful Design Of A Novel Highly Potent Nitrogen-Containing Bisphosphonate With Lower Bone Affinity. di Ebetino, F, Ebetino, F, Lundy, M, Kwaasi, A, Dunford, J, Duan, X, Triffitt, J, Mazur, A, Jeans, G, Barnett, B, Russell, R

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using en... di Tsoumpra, M, Muniz, JR, Barnett, B, Kwaasi, A, Pilka, E, Kavanagh, K, Evdokimov, A, Walter, R, Von Delft, F, Ebetino, F, Oppermann, U, Russell, G, Dunford, J

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. di Russell, R, Xia, Z, Dunford, J, Oppermann, U, Kwaasi, A, Hulley, P, Kavanagh, K, Triffitt, J, Lundy, M, Phipps, R, Barnett, B, Coxon, F, Rogers, M, Watts, N, Ebetino, F

The relationship between the chemistry and biological activity of the bisphosphonates. di Ebetino, F, Hogan, A, Sun, S, Tsoumpra, M, Duan, X, Triffitt, J, Kwaasi, A, Dunford, J, Barnett, B, Oppermann, U, Lundy, M, Boyde, A, Kashemirov, B, McKenna, C, Russell, R

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. di Russell, R, Xia, Z, Dunford, J, Oppermann, U, Kwaasi, A, Hulley, P, Kavanagh, K, Triffitt, J, Lundy, M, Phipps, R, Barnett, B, Coxon, F, Rogers, M, Watts, N, Ebetino, F

Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism... di Simoni, D, Gebbia, N, Invidiata, F, Eleopra, M, Marchetti, P, Rondanin, R, Baruchello, R, Provera, S, Marchioro, C, Tolomeo, M, Marinelli, L, Limongelli, V, Novellino, E, Kwaasi, A, Dunford, J, Buccheri, S, Caccamo, N, Dieli, F

The pharmacological profile of a novel highly potent bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate) di Lawson, M, Ebetino, F, Mazur, A, Chantry, A, Paton-Hough, J, Evans, H, Lath, D, Tsoumpra, M, Lundy, M, Dobson, R, Quijano, M, Kwaasi, A, Dunford, J, Duan, X, Triffitt, J, Jeans, G, Russell, R