LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation[S] by Cornelia Pipper, Natalie Bordag, Bernadette Reiter, Kyriakos Economides, Peter Florian, Thomas Birngruber, Frank Sinner, Manfred Bodenlenz, Anita Eberl

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1074 PK/RO modeling of WTX-124, a tumor-activated IL-2 prodrug, highlights the potential for a substantially improved therapeutic index compared to other IL-2 molecules by Christopher J Nirschl, Kyriakos Economides, Kristin Morris, Andres Salmeron, Daniel J Hicklin, Cynthia Seidel-Dugan, Kulandayan K Subramanian, Randi Isaacs, Sameer Chopra, Celesztina Domonkos

1075 Development of WTX-712, a conditionally active IL-21 INDUKINETM molecule for the treatment of cancer by Kyriakos Economides, Nesreen Ismail, Andres Salmeron, Jenna M Sullivan, Pam Aderhold, Heather R Brodkin, Celesztina Nagy-Domonkos, Daniel J Hicklin, Cynthia Seidel-Dugan, William M Winston

252 The combination of ACT and INDUKINE therapy leads to improved antitumor immunity in solid tumors by Kyriakos Economides, Kristin Morris, Andres Salmeron, Connor J Dwyer, Heather R Brodkin, Daniel J Hicklin, Cynthia Seidel-Dugan, William M Winston, Olivia G Donovan, Julie LePrevost

709 Exosome surface display of IL-12 results in tumor-retained pharmacology with superior potency and limited systemic exposure by Michael Doherty, Ke Xu, Tong Zi, Sriram Sathyanaryanan, Nuruddeen Lewis, Chang Ling Sia, Katherine Kirwin, Sonya Haupt, Gauri Mahimkar, Kevin Dooley, Su Chul Jang, Bryan Choi, Andrew Grube, Christine McCoy, Jorge Sanchez-Salazar, Scott Estes, Kyriakos Economides, Douglas Williams