HIGH THROUGHPUT SOMATIC PROFILING OF THE RAS-RAF-MAP AND PI3K-PTEN-AKT PATHWAYS IN ADVANCED COLORECTAL CANCER AND CORRELATIONS WITH RESPONSE TO CETUXIMAB by Smith, C, Claes, B, Fisher, D, Adams, R, Kaplan, R, Meade, A, Lambrechts, D, Maughan, T, Cheadle, J

Somatic profiling of the epidermal growth factor receptor pathway in tumors from patients with advanced colorectal cancer treated with chemotherapy ± cetuximab. by Smith, C, Fisher, D, Claes, B, Maughan, T, Idziaszczyk, S, Peuteman, G, Harris, R, James, MD, Meade, A, Jasani, B, Adams, R, Kenny, S, Kaplan, R, Lambrechts, D, Cheadle, J

Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis. by Es, V, Van Vught, P, Veldink, J, Andersen, P, Birve, A, Lemmens, R, Cronin, S, Van Der Kooi, A, Visser, MD, Schelhaas, H, Hardiman, O, Ragoussis, I, Lambrechts, D, Robberecht, W, Wokke, J, Ophoff, R, Van Den Berg, L

Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis. by Es, V, Van Vught, P, Veldink, J, Andersen, P, Birve, A, Lemmens, R, Cronin, S, Van Der Kooi, A, De Visser, M, Schelhaas, H, Hardiman, O, Ragoussis, I, Lambrechts, D, Robberecht, W, Wokke, J, Ophoff, R, Van Den Berg, L

Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. by Maughan, T, Adams, R, Smith, C, Meade, A, Seymour, M, Wilson, R, Idziaszczyk, S, Harris, R, Fisher, D, Kenny, S, Kay, E, Mitchell, J, Madi, A, Jasani, B, James, MD, Bridgewater, J, Kennedy, M, Claes, B, Lambrechts, D, Kaplan, R, Cheadle, J

Olmsted syndrome: exploration of the immunological phenotype. by Danso-Abeam, D, Zhang, J, Dooley, J, Staats, K, Van Eyck, L, Van Brussel, T, Zaman, S, Hauben, E, Van de Velde, M, Morren, M, Renard, M, Van Geet, C, Schaballie, H, Lambrechts, D, Tao, J, Franckaert, D, Humblet-Baron, S, Meyts, I, Liston, A

Germline copy number variants and endometrial cancer risk by Stylianou, CE, Wiggins, GAR, Lau, VL, Dennis, J, Shelling, AN, Wilson, M, Sykes, P, Amant, F, Annibali, D, De Wispelaere, W, Easton, DF, Fasching, PA, Glubb, DM, Goode, EL, Lambrechts, D, Pharoah, PDP, Scott, RJ, Tham, E, Tomlinson, I, Bolla, MK, Couch, FJ, Czene, K, Dörk, T, Dunning, AM

Genome-wide association study identifies a common variant associated with risk of endometrial cancer by Spurdle, AB, Thompson, D, Ahmed, S, Ferguson, K, Healey, C, O'Mara, T, Walker, L, Montgomery, S, Dermitzakis, E, Fahey, P, Montgomery, G, Webb, P, Fasching, P, Beckmann, M, Ekici, AB, Hein, A, Lambrechts, D, Coenegrachts, L, Vergote, I, Amant, F, Salvesen, H, Trovik, J, Njolstad, T, Helland, H, Scott, R

Genome-wide association study identifies a common variant associated with risk of endometrial cancer. by Spurdle, AB, Thompson, D, Ahmed, S, Ferguson, K, Healey, C, O'Mara, T, Walker, L, Montgomery, S, Dermitzakis, E, Fahey, P, Montgomery, G, Webb, P, Fasching, P, Beckmann, M, Ekici, AB, Hein, A, Lambrechts, D, Coenegrachts, L, Vergote, I, Amant, F, Salvesen, H, Trovik, J, Njolstad, T, Helland, H, Scott, R

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. by Aragonés, J, Schneider, M, Van Geyte, K, Fraisl, P, Dresselaers, T, Mazzone, M, Dirkx, R, Zacchigna, S, Lemieux, H, Jeoung, N, Lambrechts, D, Bishop, T, Lafuste, P, Diez-Juan, A, Harten, S, Van Noten, P, De Bock, K, Willam, C, Tjwa, M, Grosfeld, A, Navet, R, Moons, L, Vandendriessche, T, Deroose, C, Wijeyekoon, B

11q13 is a susceptibility locus for hormone receptor positive breast cancer by Lambrechts, D, Truong, T, Justenhoven, C, Humphreys, M, Wang, J, Hopper, J, Dite, G, Apicella, C, Southey, M, Schmidt, M, Broeks, A, Cornelissen, S, van Hien, R, Sawyer, E, Tomlinson, I, Kerin, M, Miller, N, Milne, R, Zamora, M, Pérez, J, Benítez, J, Hamann, U, Ko, Y, Brüning, T, Chang-Claude, J

11q13 is a susceptibility locus for hormone receptor positive breast cancer. by Lambrechts, D, Truong, T, Justenhoven, C, Humphreys, M, Wang, J, Hopper, J, Dite, G, Apicella, C, Southey, M, Schmidt, M, Broeks, A, Cornelissen, S, van Hien, R, Sawyer, E, Tomlinson, I, Kerin, M, Miller, N, Milne, R, Zamora, M, Pérez, J, Benítez, J, Hamann, U, Ko, Y, Brüning, T, Chang-Claude, J

Genome-wide association study identifies a possible susceptibility locus for endometrial cancer. by Long, J, Zheng, W, Xiang, Y, Lose, F, Thompson, D, Tomlinson, I, Yu, H, Wentzensen, N, Lambrechts, D, Dörk, T, Dubrowinskaja, N, Goodman, M, Salvesen, H, Fasching, P, Scott, R, Delahanty, R, Zheng, Y, O'Mara, T, Healey, C, Hodgson, S, Risch, H, Yang, H, Amant, F, Turmanov, N, Schwake, A

Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study. by Healey, C, Ahmed, S, O'Mara, T, Ferguson, K, Lambrechts, D, Garcia-Dios, D, Vergote, I, Amant, F, Howarth, K, Gorman, M, Hodgson, S, Tomlinson, I, Yang, H, Lissowska, J, Brinton, L, Chanock, S, Garcia-Closas, M, Hall, P, Liu, J, Shah, M, Pharoah, P, Thompson, D, Rebbeck, T, Strom, B, Dunning, A

Polymorphisms in inflammation pathway genes and endometrial cancer risk. by Delahanty, R, Xiang, Y, Spurdle, A, Beeghly-Fadiel, A, Long, J, Thompson, D, Tomlinson, I, Yu, H, Lambrechts, D, Dörk, T, Goodman, M, Zheng, Y, Salvesen, H, Bao, P, Amant, F, Beckmann, M, Coenegrachts, L, Coosemans, A, Dubrowinskaja, N, Dunning, A, Runnebaum, I, Easton, D, Ekici, AB, Fasching, P, Halle, M

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neo-antigen burden... by Temko, D, Van Gool, IC, Rayner, E, Glaire, M, Makino, S, Brown, MW, Chegwidden, L, Palles, C, Depreeuw, J, Beggs, A, Stathopoulou, C, Mason, J, Baker, A-M, Williams, M, Cerundolo, E, Rei, M, Taylor, J, Schuh, A, Ahmed, A, Amant, F, Lambrechts, D, Smit, VTHBM, Bosse, T, Graham, TA, Church, DN, Tomlinson, I

Multiomics and spatial mapping characterizes human CD8+ T cell states in cancer by Naulaerts, S, Datsi, A, Borras, DM, Antoranz Martinez, A, Messiaen, J, Vanmeerbeek, I, Sprooten, J, Laureano, RS, Govaerts, J, Panovska, D, Derweduwe, M, Sabel, MC, Rapp, M, Ni, W, Mackay, S, Van Herck, Y, Gelens, L, Venken, T, More, S, Bechter, O, Bergers, G, Liston, A, De Vleeschouwer, S, Van Den Eynde, BJ, Lambrechts, D, Verfaillie, M, Bosisio, F, Tejpar, S, Borst, J, Sorg, RV, De Smet, F, Garg, AD

Genetic risk score Mendelian randomization shows that obesity measured as body mass index, but not waist:hip ratio, is causal for endometrial cancer. by Painter, J, O'Mara, T, Marquart, L, Webb, P, Attia, J, Medland, S, Cheng, T, Dennis, J, Holliday, E, McEvoy, M, Scott, R, Ahmed, S, Healey, C, Shah, M, Gorman, M, Martin, L, Hodgson, S, Beckmann, M, Ekici, A, Fasching, P, Hein, A, Rübner, M, Czene, K, Darabi, H, Hall, P, Li, J, Dork, T, Durst, M, Hillemanns, P, Runnebaum, I, Amant, F, Annibali, D, Depreeuw, J, Lambrechts, D, Neven, P, Cunningham, J, Dowdy, S, Goode, E, Fridley, B, Winham, S, Njolstad, T, Salvesen, H, Trovik, J, Werner, H, Ashton, K, Otton, G, Proietto, A, Mints, M, Tham, E, Bolla, M, Michailidou, K, Wang, Q, Tyrer, J, Hopper, J, Peto, J, Swerdlow, A, Burwinkel, B, Brenner, H, Meindl, A, Brauch, H, Lindblom, A, Chang-Claude, J, Couch, F, Giles, G, Kristensen, V, Cox, A, Pharoah, P, Tomlinson, I, Dunning, A, Easton, D, Thompson, D, Spurdle, A

Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses by Painter, JN, O'Mara, TA, Morris, AP, Cheng, THT, Gorman, M, Martin, L, Hodson, S, Jones, A, Martin, NG, Gordon, S, Henders, AK, Attia, J, McEvoy, M, Holliday, EG, Scott, RJ, Webb, PM, Fasching, PA, Beckmann, MW, Ekici, AB, Hein, A, Rübner, M, Hall, P, Czene, K, Dörk, T, Dürst, M, Hillemanns, P, Runnebaum, I, Lambrechts, D, Amant, F, Annibali, D, Depreeuw, J, Vanderstichele, A, Goode, EL, Cunningham, JM, Dowdy, SC, Winham, SJ, Trovik, J, Hoivik, E, Werner, HMJ, Krakstad, C, Ashton, K, Otton, G, Proietto, T, Tham, E, Mints, M, Ahmed, S, Healey, CS, Shah, M, Pharoah, PDP, Dunning, AM, Dennis, J, Bolla, MK, Michailidou, K, Wang, Q, Tyrer, JP, Hopper, JL, Peto, J, Swerdlow, AJ, Burwinkel, B, Brenner, H, Meindl, A, Brauch, H, Lindblom, A, Chang-Claude, J, Couch, FJ, Giles, GG, Kristensen, VN, Cox, A, Zondervan, KT, Nyholt, DR, MacGregor, S, Montgomery, GW, Tomlinson, I, Easton, DF, Thompson, DJ, Spurdle, AB

Five endometrial cancer risk loci identified through genome-wide association analysis. by Cheng, T, Thompson, D, O'Mara, T, Painter, J, Glubb, D, Flach, S, Lewis, A, French, J, Freeman-Mills, L, Church, D, Gorman, M, Martin, L, Hodgson, S, Webb, P, Attia, J, Holliday, E, McEvoy, M, Scott, R, Henders, A, Martin, N, Montgomery, G, Nyholt, D, Ahmed, S, Healey, C, Shah, M, Dennis, J, Fasching, P, Beckmann, M, Hein, A, Ekici, A, Hall, P, Czene, K, Darabi, H, Li, J, Dörk, T, Dürst, M, Hillemanns, P, Runnebaum, I, Amant, F, Schrauwen, S, Zhao, H, Lambrechts, D, Depreeuw, J, Dowdy, S, Goode, E, Fridley, B, Winham, S, Njølstad, T, Salvesen, H, Trovik, J, Werner, H, Ashton, K, Otton, G, Proietto, T, Liu, T, Mints, M, Tham, E, Li, M, Yip, S, Wang, J, Bolla, M, Michailidou, K, Wang, Q, Tyrer, J, Dunlop, M, Houlston, R, Palles, C, Hopper, J, Peto, J, Swerdlow, A, Burwinkel, B, Brenner, H, Meindl, A, Brauch, H, Lindblom, A, Chang-Claude, J, Couch, F, Giles, G, Kristensen, V, Cox, A, Cunningham, J, Pharoah, P, Dunning, A, Edwards, S, Easton, D, Tomlinson, I, Spurdle, A