Analysis and functional validation of candidate variants arising from human whole genome sequencing by Lange, L

Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. by Guo, Y, Lanktree, M, Taylor, K, Hakonarson, H, Lange, L, Keating, B

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. by Asselbergs, F, Guo, Y, van Iperen, E, Sivapalaratnam, S, Tragante, V, Lanktree, M, Lange, L, Almoguera, B, Appelman, Y, Barnard, J, Baumert, J, Beitelshees, A, Bhangale, T, Chen, Y, Gaunt, T, Gong, Y, Hopewell, J, Johnson, T, Kleber, M, Langaee, T, Li, M, Li, Y, Liu, K, McDonough, C, Meijs, M

Genome-wide Comparison of African-Ancestry Populations from CARe and Other Cohorts Reveals Signals of Natural Selection by Bhatia, G, Patterson, N, Pasaniuc, B, Zaitlen, N, Genovese, G, Pollack, S, Mallick, S, Myers, S, Tandon, A, Spencer, C, Palmer, C, Adeyemo, A, Akylbekova, E, Cupples, L, Divers, J, Fornage, M, Kao, W, Lange, L, Li, M, Musani, S, Mychaleckyj, J, Ogunniyi, A, Papanicolaou, G, Rotimi, C, Rotter, J

Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables. by Burgess, S, Thompson, S, Burgess, S, Thompson, S, Andrews, G, Samani, N, Hall, A, Whincup, P, Morris, R, Lawlor, D, Davey Smith, G, Timpson, N, Ebrahim, S, Ben-Shlomo, Y, Davey Smith, G, Timpson, N, Brown, M, Ricketts, S, Sandhu, M, Reiner, A, Psaty, B, Lange, L, Cushman, M, Hung, J, Thompson, P

Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection. by Bhatia, G, Patterson, N, Pasaniuc, B, Zaitlen, N, Genovese, G, Pollack, S, Mallick, S, Myers, S, Tandon, A, Spencer, C, Palmer, C, Adeyemo, A, Akylbekova, E, Cupples, L, Divers, J, Fornage, M, Kao, W, Lange, L, Li, M, Musani, S, Mychaleckyj, J, Ogunniyi, A, Papanicolaou, G, Rotimi, C, Rotter, J

Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia. by Stitziel, N, Fouchier, S, Sjouke, B, Peloso, G, Moscoso, A, Auer, P, Goel, A, Gigante, B, Barnes, T, Melander, O, Orho-Melander, M, Duga, S, Sivapalaratnam, S, Nikpay, M, Martinelli, N, Girelli, D, Jackson, R, Kooperberg, C, Lange, L, Ardissino, D, McPherson, R, Farrall, M, Watkins, H, Reilly, M, Rader, D

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci by Asselbergs, F, Asselbergs, F, Asselbergs, F, Guo, Y, Guo, Y, Van Iperen, E, Van Iperen, E, Sivapalaratnam, S, Tragante, V, Tragante, V, Lanktree, M, Lange, L, Almoguera, B, Appelman, Y, Barnard, J, Baumert, J, Beitelshees, A, Bhangale, T, Chen, Y, Gaunt, T, Gong, Y, Hopewell, J, Johnson, T, Kleber, M, Kleber, M

Loss-of-function mutations in APOC3, triglycerides, and coronary disease. by Crosby, J, Peloso, G, Auer, P, Crosslin, DR, Stitziel, N, Lange, L, Lu, Y, Tang, Z, Zhang, H, Hindy, G, Masca, N, Stirrups, K, Kanoni, S, Do, R, Jun, G, Hu, Y, Kang, H, Xue, C, Goel, A, Farrall, M, Duga, S, Merlini, P, Asselta, R, Girelli, D, Olivieri, O

Inactivating mutations in NPC1L1 and protection from coronary heart disease. by Stitziel, N, Won, H, Morrison, A, Peloso, G, Do, R, Lange, L, Fontanillas, P, Gupta, N, Duga, S, Goel, A, Farrall, M, Saleheen, D, Ferrario, P, König, I, Asselta, R, Merlini, P, Marziliano, N, Notarangelo, M, Schick, U, Auer, P, Assimes, T, Reilly, M, Wilensky, R, Rader, D, Hovingh, G

Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia by Stitziel, N, Fouchier, S, Sjouke, B, Peloso, G, Moscoso, A, Auer, P, Goel, A, Gigante, B, Barnes, T, Melander, O, Orho-Melander, M, Duga, S, Sivapalaratnam, S, Nikpay, M, Martinelli, N, Girelli, D, Jackson, R, Kooperberg, C, Lange, L, Ardissino, D, McPherson, R, Farrall, M, Watkins, H, Reilly, M, Rader, D

Association of exome sequences with plasma C-reactive protein levels in >9000 participants. by Schick, U, Auer, P, Bis, J, Lin, H, Wei, P, Pankratz, N, Lange, L, Brody, J, Stitziel, N, Kim, D, Carlson, C, Fornage, M, Haessler, J, Hsu, L, Jackson, R, Kooperberg, C, Leal, S, Psaty, B, Boerwinkle, E, Tracy, R, Ardissino, D, Shah, S, Willer, C, Loos, R, Melander, O

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. by Do, R, Stitziel, N, Won, H, Jørgensen, AB, Duga, S, Angelica Merlini, P, Kiezun, A, Farrall, M, Goel, A, Zuk, O, Guella, I, Asselta, R, Lange, L, Peloso, G, Auer, P, Girelli, D, Martinelli, N, Farlow, D, DePristo, M, Roberts, R, Stewart, A, Saleheen, D, Danesh, J, Epstein, SE, Sivapalaratnam, S

Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation by Danesh, J, Collaborat, C, Hingorani, A, Wensley, F, Casas, J, Smeeth, L, Samani, N, Hall, A, Whincup, P, Morris, R, Lawlor, D, Smith, G, Timpson, N, Ebrahim, S, Brown, M, Sandhu, M, Reiner, A, Psaty, B, Lange, L, Cushman, M, Tracy, R, Nordestgaard, BG, Tybjaerg-Hansen, A, Zacho, J, Hung, J

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. by Freathy, R, Mook-Kanamori, DO, Sovio, U, Prokopenko, I, Timpson, N, Berry, D, Warrington, N, Widen, E, Hottenga, J, Kaakinen, M, Lange, L, Bradfield, J, Kerkhof, M, Marsh, J, Mägi, R, Chen, C, Lyon, H, Kirin, M, Adair, L, Aulchenko, Y, Bennett, A, Borja, J, Bouatia-Naji, N, Charoen, P, Coin, L

Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. by Pasaniuc, B, Zaitlen, N, Lettre, G, Chen, G, Tandon, A, Kao, W, Ruczinski, I, Fornage, M, Siscovick, D, Zhu, X, Larkin, E, Lange, L, Cupples, L, Yang, Q, Akylbekova, E, Musani, S, Divers, J, Mychaleckyj, J, Li, M, Papanicolaou, G, Millikan, R, Ambrosone, C, John, E, Bernstein, L, Zheng, W, Hu, J, Ziegler, R, Nyante, S, Bandera, E, Ingles, SA, Press, M, Chanock, S, Deming, S, Rodriguez-Gil, J, Palmer, C, Buxbaum, S, Ekunwe, L, Hirschhorn, J, Henderson, B, Myers, S, Haiman, C, Reich, D, Patterson, N, Wilson, J, Price, A

Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases by Pagnamenta, AT, Camps, C, Giacopuzzi, E, Taylor, JM, Hashim, M, Calpena, E, Kaisaki, PJ, Hashimoto, A, Yu, J, Sanders, E, Schwessinger, R, Hughes, JR, Lunter, G, Dreau, H, Ferla, M, Lange, L, Kesim, Y, Ragoussis, V, Vavoulis, DV, Allroggen, H, Ansorge, O, Babbs, C, Banka, S, Baños-Piñero, B, Beeson, D, Ben-Ami, T, Bennett, DL, Bento, C, Blair, E, Brasch-Andersen, C, Bull, KR, Cario, H, Cilliers, D, Conti, V, Davies, EG, Dhalla, F, Dacal, BD, Dong, Y, Dunford, JE, Guerrini, R, Harris, AL, Hartley, J, Hollander, G, Javaid, K, Kane, M, Kelly, D, Kelly, D, Knight, SJL, Kreins, AY, Kvikstad, EM, Lines, KE, Lord, SR, Lu, X, Marsden, B, Ormondroyd, E, Stevenson, M, Twigg, SRF, Uhlig, HH, Watkins, H, Schuh, AH, Wilkie, AOM, Taylor, JC

Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? by Heid, I, Huth, C, Loos, R, Kronenberg, F, Adamkova, V, Anand, S, Ardlie, K, Biebermann, H, Bjerregaard, P, Boeing, H, Bouchard, C, Ciullo, M, Cooper, J, Corella, D, Dina, C, Engert, J, Fisher, E, Francès, F, Froguel, P, Hebebrand, J, Hegele, R, Hinney, A, Hoehe, MR, Hu, F, Hubacek, J, Humphries, SE, Hunt, S, Illig, T, Järvelin, MR, Kaakinen, M, Kollerits, B, Krude, H, Kumar, J, Lange, L, Langer, B, Li, S, Luchner, A, Lyon, H, Meyre, D, Mohlke, K, Mooser, V, Nebel, A, Nguyen, T, Paulweber, B, Perusse, L, Qi, L, Rankinen, T, Rosskopf, D, Schreiber, S, Sengupta, S, Sorice, R, Suk, A, Thorleifsson, G, Thorsteinsdottir, U, Völzke, H, Vimaleswaran, K, Wareham, N, Waterworth, D, Yusuf, S, Lindgren, C, McCarthy, M, Lange, C, Hirschhorn, J, Laird, N, Wichmann, H

Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation by Chu, A, Deng, X, Fisher, V, Drong, A, Zhang, Y, Feitosa, M, Liu, C, Weeks, O, Choh, A, Duan, Q, Dyer, T, Eicher, J, Guo, X, Heard-Costa, N, Kacprowski, T, Kent, J, Lange, L, Liu, X, Lohman, K, Lu, L, Mahajan, A, O'Connell, J, Parihar, A, Peralta, J, Smith, A, Zhang, Y, Homuth, G, Kissebah, A, Kullberg, J, Laqua, R, Launer, L, Nauck, M, Olivier, M, Peyser, P, Terry, J, Wojczynski, M, Yao, J, Bielak, L, Blangero, J, Borecki, I, Bowden, D, Carr, J, Czerwinski, S, Ding, J, Friedrich, N, Gudnason, V, Harris, T, Ingelsson, E, Johnson, A, Kardia, S, Langefeld, C, Lind, L, Liu, Y, Mitchell, B, Morris, A, Mosley, T, Rotter, J, Shuldiner, A, Towne, B, Völzke, H, Wallaschofski, H, Wilson, J, Allison, M, Lindgren, C, Goessling, W, Cupples, L, Steinhauser, M, Fox, C

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. by Lange, L, Hu, Y, Zhang, H, Xue, C, Schmidt, E, Tang, Z, Bizon, C, Lange, E, Smith, J, Turner, E, Jun, G, Kang, H, Peloso, G, Auer, P, Li, K, Flannick, J, Zhang, J, Fuchsberger, C, Gaulton, K, Lindgren, C, Locke, A, Manning, A, Sim, X, Rivas, M, Holmen, O, Gottesman, O, Lu, Y, Ruderfer, D, Stahl, E, Duan, Q, Li, Y, Durda, P, Jiao, S, Isaacs, A, Hofman, A, Bis, J, Correa, A, Griswold, M, Jakobsdottir, J, Smith, A, Schreiner, P, Feitosa, M, Zhang, Q, Huffman, J, Crosby, J, Wassel, C, Do, R, Franceschini, N, Martin, L, Robinson, J, Assimes, T, Crosslin, DR, Rosenthal, E, Tsai, M, Rieder, M, Farlow, D, Folsom, A, Lumley, T, Fox, E, Carlson, C, Peters, U, Jackson, R, van Duijn, C, Uitterlinden, A, Levy, D, Rotter, J, Taylor, H, Gudnason, V, Siscovick, D, Fornage, M, Borecki, I, Hayward, C, Rudan, I, Chen, Y, Bottinger, E, Loos, R, Sætrom, P, Hveem, K, Boehnke, M, Groop, L, McCarthy, M, Meitinger, T, Ballantyne, C, Gabriel, S, O'Donnell, C, Post, W, North, K, Reiner, A, Boerwinkle, E, Psaty, B, Altshuler, D, Kathiresan, S, Lin, D, Jarvik, G, Cupples, L, Kooperberg, C, Wilson, J, Nickerson, D, Abecasis, G, Rich, S, Tracy, R, Willer, C