Pre-clinical modelling of rectal cancer to develop novel radiotherapy-based treatment strategies 由 Michael A. Gillespie, Colin W. Steele, Tamsin R.M. Lannagan, Owen J. Sansom, Campbell S.D. Roxburgh

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Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tum... 由 Reshmi Nair, Tamsin R. M. Lannagan, Rene Jackstadt, Anna Andrusaite, John Cole, Caitlin Boyne, Robert J. B. Nibbs, Owen J. Sansom, Simon Milling

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Enterocyte-like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability 由 Arezo Torang, Aleksandar B. Kirov, Veerle Lammers, Kate Cameron, Valérie M. Wouters, Rene F. Jackstadt, Tamsin R. M. Lannagan, Joan H. de Jong, Jan Koster, Owen Sansom, Jan Paul Medema

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Delineating proinflammatory microenvironmental signals by ex vivo modeling of the immature intestinal stroma 由 Mari Ichinose, Nobumi Suzuki, Tongtong Wang, Josephine A. Wright, Tamsin R. M. Lannagan, Laura Vrbanac, Hiroki Kobayashi, Krystyna Gieniec, Jia Q. Ng, Souzaburo Ihara, Chris Mavrangelos, Yoku Hayakawa, Patrick Hughes, Daniel L. Worthley, Susan L. Woods

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Molecular Subtyping Resource: a user-friendly tool for rapid biological discovery from transcriptional data 由 Baharak Ahmaderaghi, Raheleh Amirkhah, James Jackson, Tamsin R. M. Lannagan, Kathryn Gilroy, Sudhir B. Malla, Keara L. Redmond, Gerard Quinn, Simon S. McDade, ACRCelerate Consortium, Tim Maughan, Simon Leedham, Andrew S. D. Campbell, Owen J. Sansom, Mark Lawler, Philip D. Dunne

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Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification 由 Kleeman, S, Koelzar, V, Jones, HJS, Vazquez, E, Davis, H, East, JE, Arnold, R, Koppens, MAJ, Blake, A, Domingo, E, Cunningham, C, Beggs, AD, Pestinger, V, Loughrey, MB, Wang, L-M, Lannagan, TRM, Woods, SL, Worthley, D, Tomlinson, I, Dunne, PD, Maughan, T, Leedham, SJ

Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging 由 Eva C. Freckmann, Emma Sandilands, Erin Cumming, Matthew Neilson, Alvaro Román-Fernández, Konstantina Nikolatou, Marisa Nacke, Tamsin R. M. Lannagan, Ann Hedley, David Strachan, Mark Salji, Jennifer P. Morton, Lynn McGarry, Hing Y. Leung, Owen J. Sansom, Crispin J. Miller, David M. Bryant

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Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis 由 Lannagan, T, Lee, Y, Wang, T, Roper, J, Bettington, M, Fennell, L, Vrbanac, L, Jonavicius, L, Somashekar, R, Gieniec, K, Yang, M, Ng, J, Suzuki, N, Ichinose, M, Wright, J, Kobayashi, H, Putoczki, T, Hayakawa, Y, Leedham, S, Abud, H, Yilmaz, Ö, Marker, J, Klebe, S, Wirapati, P, Mukherjee, S, Tejpar, S, Leggett, B, Whitehall, V, Worthley, D, Woods, S

Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis 由 Jia Q. Ng, Toghrul H. Jafarov, Christopher B. Little, Tongtong Wang, Abdullah M. Ali, Yan Ma, Georgette A. Radford, Laura Vrbanac, Mari Ichinose, Samuel Whittle, David J. Hunter, Tamsin R. M. Lannagan, Nobumi Suzuki, Jarrad M. Goyne, Hiroki Kobayashi, Timothy C. Wang, David R. Haynes, Danijela Menicanin, Stan Gronthos, Daniel L. Worthley, Susan L. Woods, Siddhartha Mukherjee

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Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia 由 Catherine E. Bond, Cheng Liu, Futoshi Kawamata, Diane M. McKeone, Winnie Fernando, Saara Jamieson, Sally-Ann Pearson, Alexandra Kane, Susan L. Woods, Tamsin R. M. Lannagan, Roshini Somashekar, Young Lee, Troy Dumenil, Gunter Hartel, Kevin J. Spring, Jennifer Borowsky, Lochlan Fennell, Mark Bettington, Jason Lee, Daniel L. Worthley, Barbara A. Leggett, Vicki L. J. Whitehall

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Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia 由 Gil Vasquez, E, Nasreddin, N, Valbuena, G, Mulholland, E, Belnoue Davis, H, Eggington, H, Schenck, R, Wouters, V, Wirapati, P, Gilroy, K, Lannagan, T, Flanagan, D, Najumudeen, A, Omwenga, S, McCorrry, A, Easton, A, Koelzer, V, East, J, Morton, D, Trusolino, L, Maughan, T, Campbell, A, Loughrey, M, Dunne, P, Tsantoulis, P, Huels, D, Tejpar, S, Sansom, O, Leedham, S

Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer 由 Malla, SB, Byrne, RM, Lafarge, MW, Corry, SM, Fisher, NC, Tsantoulis, PK, Mills, ML, Ridgway, RA, Lannagan, TRM, Najumudeen, AK, Gilroy, KL, Amirkhah, R, Maguire, SL, Mulholland, EJ, Belnoue-Davis, HL, Grassi, E, Viviani, M, Rogan, E, Redmond, KL, Sakhnevych, S, McCooey, AJ, Bull, C, Hoey, E, Sinevici, N, Domingo, E, Blake, A, Maughan, TS, Leedham, SJ, Koelzer, VH

Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia 由 Candice R. Gurbatri, Georgette A. Radford, Laura Vrbanac, Jongwon Im, Elaine M. Thomas, Courtney Coker, Samuel R. Taylor, YoungUk Jang, Ayelet Sivan, Kyu Rhee, Anas A. Saleh, Tiffany Chien, Fereshteh Zandkarimi, Ioana Lia, Tamsin R. M. Lannagan, Tongtong Wang, Josephine A. Wright, Hiroki Kobayashi, Jia Q. Ng, Matt Lawrence, Tarik Sammour, Michelle Thomas, Mark Lewis, Lito Papanicolas, Joanne Perry, Tracy Fitzsimmons, Patricia Kaazan, Amanda Lim, Alexandra M. Stavropoulos, Dion A. Gouskos, Julie Marker, Cheri Ostroff, Geraint Rogers, Nicholas Arpaia, Daniel L. Worthley, Susan L. Woods, Tal Danino

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JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors 由 Kathryn A. F. Pennel, Phimmada Hatthakarnkul, Colin S. Wood, Guang-Yu Lian, Sara S. F. Al-Badran, Jean A. Quinn, Assya Legrini, Jitwadee Inthagard, Peter G. Alexander, Hester van Wyk, Ahmad Kurniawan, Umar Hashmi, Michael A. Gillespie, Megan Mills, Aula Ammar, Jennifer Hay, Ditte Andersen, Colin Nixon, Selma Rebus, David K. Chang, Caroline Kelly, Andrea Harkin, Janet Graham, David Church, Ian Tomlinson, Mark Saunders, Tim Iveson, Tamsin R. M. Lannagan, Rene Jackstadt, Noori Maka, Paul G. Horgan, Campbell S. D. Roxburgh, Owen J. Sansom, Donald C. McMillan, Colin W. Steele, Nigel B. Jamieson, James H. Park, Antonia K. Roseweir, Joanne Edwards

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