Patient involvement to inform the design of a clinical trial in postbariatric hypoglycaemia by Matthias Hepprich, Marc Y. Donath, Lars G. Hemkens

Get full text

Meta-research on pragmatism of randomized trials: rationale and design of the PragMeta database by Julian Hirt, Perrine Janiaud, Pascal Düblin, Lars G. Hemkens

Get full text

Clinical trial research on COVID-19 in Germany – a systematic analysis [version 1; peer review: 2 approved] by Julian Hirt, Abeelan Rasadurai, Matthias Briel, Pascal Düblin, Perrine Janiaud, Lars G. Hemkens

Get full text

Definitions of digital biomarkers: a systematic mapping of the biomedical literature by Lars G Hemkens, Julian Hirt, Perrine Janiaud, Ana Karen Macias Alonso, Tim Woelfle

Get full text

Online randomized controlled experiments at scale: lessons and extensions to medicine by Ron Kohavi, Diane Tang, Ya Xu, Lars G. Hemkens, John P. A. Ioannidis

Get full text

Effect of wearing glasses for prevention of SARS-CoV-2 on visits to health care providers—additional results from a randomized controlled trial by Ingeborg Hess Elgersma, Petter Elstrøm, Lars G. Hemkens, Arnfinn Helleve, Oliver Kacelnik, Atle Fretheim

Get full text

Frequency of multiple changes to prespecified primary outcomes of clinical trials completed between 2009 and 2017 in German university medical centers: A meta-research study. by Martin Holst, Martin Haslberger, Samruddhi Yerunkar, Daniel Strech, Lars G Hemkens, Benjamin G Carlisle

Get full text

All nations depend on the global knowledge pool--analysis of country of origin of studies used for health technology assessments in Germany. by Kirsten H Herrmann, Robert Wolff, Fueloep Scheibler, Siw Waffenschmidt, Lars G Hemkens, Stefan Sauerland, Gerd Antes

Get full text

Exploring the characteristics, methods and reporting of systematic reviews with meta-analyses of time-to-event outcomes: a meta-epidemiological study by Marius Goldkuhle, Caroline Hirsch, Claire Iannizzi, Ana-Mihaela Zorger, Ralf Bender, Elvira C. van Dalen, Lars G. Hemkens, Ina Monsef, Nina Kreuzberger, Nicole Skoetz

Get full text

Single-dose versus 3-day cotrimoxazole prophylaxis in transurethral resection or greenlight laser vaporisation of the prostate: study protocol for a multicentre randomised placebo... by Benjamin Speich, Kathrin Bausch, Jan A. Roth, Lars G. Hemkens, Hannah Ewald, Deborah R. Vogt, Nicole Bruni, Stefanie Deuster, Hans-H. Seifert, Andreas F. Widmer

Get full text

Towards the development of a comprehensive framework: Qualitative systematic survey of definitions of clinical research quality. by Belinda von Niederhäusern, Stefan Schandelmaier, Marie Mi Bonde, Nicole Brunner, Lars G Hemkens, Marielle Rutquist, Neera Bhatnagar, Gordon H Guyatt, Christiane Pauli-Magnus, Matthias Briel

Get full text

Ten simple rules for good research practice. by Simon Schwab, Perrine Janiaud, Michael Dayan, Valentin Amrhein, Radoslaw Panczak, Patricia M Palagi, Lars G Hemkens, Meike Ramon, Nicolas Rothen, Stephen Senn, Eva Furrer, Leonhard Held

Get full text

Glucagon-like peptide-1 analogues: a new way to quit smoking? (SKIP)—a structured summary of a study protocol for a randomized controlled study by Sophia Lengsfeld, Thilo Burkard, Andrea Meienberg, Nica Jeanloz, David Coynel, Deborah R. Vogt, Lars G. Hemkens, Benjamin Speich, Davide Zanchi, Tobias E. Erlanger, Mirjam Christ-Crain, Bettina Winzeler

Get full text

Contrasting evidence to reimbursement reality for off-label use (OLU) of drug treatments in cancer care: rationale and design of the CEIT-OLU project by Matthias Briel, Lars G Hemkens, Amanda Katherina Herbrand, Andreas Michael Schmitt, Stefan Diem, Hannah Ewald, Anouk Hoogkamer, Markus Joerger, Kimberly Alba Mc Cord, Urban Novak, Sirintip Sricharoenchai, Benjamin Kasenda

Get full text

The Comparative Effectiveness of Innovative Treatments for Cancer (CEIT-Cancer) project: Rationale and design of the database and the collection of evidence available at approval o... by Aviv Ladanie, Benjamin Speich, Florian Naudet, Arnav Agarwal, Tiago V. Pereira, Francesco Sclafani, Juan Martin-Liberal, Thomas Schmid, Hannah Ewald, John P. A. Ioannidis, Heiner C. Bucher, Benjamin Kasenda, Lars G. Hemkens

Get full text

Effect of dulaglutide in promoting abstinence during smoking cessation: a single-centre, randomized, double-blind, placebo-controlled, parallel group trialResearch in context by Sophia Lengsfeld, Thilo Burkard, Andrea Meienberg, Nica Jeanloz, Tanja Vukajlovic, Katja Bologna, Michelle Steinmetz, Cemile Bathelt, Clara O. Sailer, Deborah R. Vogt, Lars G. Hemkens, Benjamin Speich, Sandrine A. Urwyler, Jill Kühne, Fabienne Baur, Linda N. Lutz, Tobias E. Erlanger, Mirjam Christ-Crain, Bettina Winzeler

Get full text

A study protocol for the development of a SPIRIT extension for trials conducted using cohorts and routinely collected data (SPIRIT-ROUTINE) [version 1; peer review: 2 approved] by Megan McCarthy, Linda O'Keeffe, Paula R. Williamson, Matthew R. Sydes, Amanda Farrin, Fiona Lugg-Widger, Gwyneth Davies, Kerry Avery, An-Wen Chan, Linda Kwakkenbos, Brett D. Thombs, Alan Watkins, Lars G. Hemkens, Chris Gale, Merrick Zwarenstein, Sinead M. Langan, Lehana Thabane, Edmund Juszczak, David Moher, Patricia M. Kearney

Get full text

Effect of dulaglutide in promoting abstinence during smoking cessation: 12-month follow-up of a single-centre, randomised, double-blind, placebo-controlled, parallel group trialRes... by Hualin Lüthi, Sophia Lengsfeld, Thilo Burkard, Andrea Meienberg, Nica Jeanloz, Tanja Vukajlovic, Katja Bologna, Michelle Steinmetz, Cemile Bathelt, Clara O. Sailer, Mirjam Laager, Deborah R. Vogt, Lars G. Hemkens, Benjamin Speich, Sandrine A. Urwyler, Jill Kühne, Fabienne Baur, Linda N. Lutz, Tobias E. Erlanger, Mirjam Christ-Crain, Bettina Winzeler

Get full text

Resource use, costs, and approval times for planning and preparing a randomized clinical trial before and after the implementation of the new Swiss human research legislation. by Benjamin Speich, Nadine Schur, Dmitry Gryaznov, Belinda von Niederhäusern, Lars G Hemkens, Stefan Schandelmaier, Alain Amstutz, Benjamin Kasenda, Christiane Pauli-Magnus, Elena Ojeda-Ruiz, Yuki Tomonaga, Kimberly McCord, Alain Nordmann, Erik von Elm, Matthias Briel, Matthias Schwenkglenks, a collaboration of the MARTA (MAking Randomized Trials Affordable) and ASPIRE (Adherence to Standard Protocol Items: REcommendations for interventional trials) Study Groups

Get full text

Protocol for the development of a CONSORT extension for RCTs using cohorts and routinely collected health data by Linda Kwakkenbos, Edmund Juszczak, Lars G Hemkens, Margaret Sampson, Ole Fröbert, Clare Relton, Chris Gale, Merrick Zwarenstein, Sinéad M Langan, David Moher, Isabelle Boutron, Philippe Ravaud, Marion K Campbell, Kimberly A Mc Cord, Tjeerd P van Staa, Lehana Thabane, Rudolf Uher, Helena M Verkooijen, Eric I Benchimol, David Erlinge, Maureen Sauvé, David Torgerson, Brett D Thombs

Get full text