Editorial: Molecular and cellular mechanisms of synaptopathies: emerging synaptic aging-related molecular pathways in neurological disorders by Hector Ramiro Quintá, Hector Ramiro Quintá, Hector Ramiro Quintá, Laura Ibanez, Laura Ibanez, Laura Ibanez, Carlos Cruchaga, Carlos Cruchaga, Carlos Cruchaga, Dario Maschi

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Spatio-Temporal Analysis of Drought with SPEI in the State of Mexico and Mexico City by Mauricio Carrillo-Carrillo, Laura Ibáñez-Castillo, Ramón Arteaga-Ramírez, Gustavo Arévalo-Galarza

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Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease by Maria V. Fernández, Maria V. Fernández, John Budde, John Budde, Jorge L. Del-Aguila, Jorge L. Del-Aguila, Laura Ibañez, Laura Ibañez, Yuetiva Deming, Yuetiva Deming, Oscar Harari, Oscar Harari, Joanne Norton, Joanne Norton, John C. Morris, John C. Morris, Alison M. Goate, NIA-LOAD family study group, NCRAD, Carlos Cruchaga, Carlos Cruchaga

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Verificación de procedimientos numéricos de simulación de maniobras en compuertas by Gilberto de Jesús López-Canteñs, Víctor Prado-Hernández, Benjamín de León-Mojarro, Víctor Manuel Ruiz-Carmona, Mauricio Carrillo-García, Laura Ibáñez-Castillo, Eduardo Arteaga-Tovar

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HIV-infection, atherosclerosis and the inflammatory pathway: candidate gene study in a Spanish HIV-infected population. by Laura Ibáñez, Pablo Sebastián Velli, Roser Font, Angeles Jaén, Josep Royo, Daniel Irigoyen, Mireia Cairó, Alejandro De la Sierra, María Jesús Arranz, David Gallardo, David Dalmau

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Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels by Laura Ibanez, Umber Dube, Benjamin Saef, John Budde, Kathleen Black, Alexandra Medvedeva, Jorge L. Del-Aguila, Albert A. Davis, Joel S. Perlmutter, Oscar Harari, Bruno A. Benitez, Carlos Cruchaga

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Circulating blood circular RNA in Parkinson’s Disease; from involvement in pathology to diagnostic tools in at-risk individuals by Aleksandra Beric, Yichen Sun, Santiago Sanchez, Charissa Martin, Tyler Powell, Ravindra Kumar, Jose Adrian Pardo, Gauri Darekar, Jessie Sanford, Devin Dikec, Bridget Phillips, Juan A. Botia, Carlos Cruchaga, Laura Ibanez

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Cell-free RNA signatures predict Alzheimer’s disease by Alejandro Cisterna-García, Aleksandra Beric, Muhammad Ali, Jose Adrian Pardo, Hsiang-Han Chen, Maria Victoria Fernandez, Joanne Norton, Jen Gentsch, Kristy Bergmann, John Budde, Joel S. Perlmutter, John C. Morris, Carlos Cruchaga, Juan A. Botia, Laura Ibanez

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Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review by Nuria P Torres-Aguila, Caty Carrera, Elena Muiño, Natalia Cullell, Jara Cárcel-Márquez, Cristina Gallego-Fabrega, Jonathan González-Sánchez, Alejandro Bustamante, Pilar Delgado, Laura Ibañez, Laura Heitsch, Jerzy Krupinski, Joan Montaner, Joan Martí-Fàbregas, Carlos Cruchaga, Jin-Moo Lee, Israel Fernandez-Cadenas

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Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease. by Maria Victoria Fernández, Jong Hun Kim, John P Budde, Kathleen Black, Alexandra Medvedeva, Ben Saef, Yuetiva Deming, Jorge Del-Aguila, Laura Ibañez, Umber Dube, Oscar Harari, Joanne Norton, Rachel Chasse, John C Morris, Alison Goate, NIA-LOAD family study group, NCRAD, Carlos Cruchaga

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A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain by Jorge L. Del-Aguila, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Maria Victoria Fernandez, Laura Ibanez, Joseph Bradley, Fengxian Wang, Kristy Bergmann, Richard Davenport, John C. Morris, David M. Holtzman, Richard J. Perrin, Bruno A. Benitez, Joseph Dougherty, Carlos Cruchaga, Oscar Harari

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Predictive Models for Assessing Patients’ Response to Treatment in Metastatic Prostate Cancer: A Systematic Review by Ailbhe Lawlor, Carol Lin, Juan Gómez Rivas, Laura Ibáñez, Pablo Abad López, Peter-Paul Willemse, Muhammad Imran Omar, Sebastiaan Remmers, Philip Cornford, Pawel Rajwa, Rossella Nicoletti, Giorgio Gandaglia, Jeremy Yuen-Chun Teoh, Jesús Moreno Sierra, Asieh Golozar, Anders Bjartell, Susan Evans-Axelsson, James N'Dow, Jihong Zong, Maria J. Ribal, Monique J. Roobol, Mieke Van Hemelrijck, Katharina Beyer

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Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease by Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S. Perlmutter, Dominantly Inherited Alzheimer Network (DIAN) Consortia, Laura Ibanez, Richard J. Perrin, Yun Ju Sung, Carlos Cruchaga

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Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease by Anna Hofmann, Lisa M. Häsler, Marius Lambert, Stephan A. Kaeser, Susanne Gräber-Sultan, Ulrike Obermüller, Elke Kuder-Buletta, Christian la Fougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Nick C. Fox, Natalie S. Ryan, Henrik Zetterberg, Jorge J. Llibre-Guerra, Richard J. Perrin, Laura Ibanez, Peter R. Schofield, William S. Brooks, Gregory S. Day, Martin R. Farlow, Ricardo F. Allegri, Patricio Chrem Mendez, Takeshi Ikeuchi, Kensaku Kasuga, Jae-Hong Lee, Jee Hoon Roh, Hiroshi Mori, Francisco Lopera, Randall J. Bateman, Eric McDade, Brian A. Gordon, Jasmeer P. Chhatwal, Mathias Jucker, Stephanie A. Schultz, Dominantly Inherited Alzheimer Network

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Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center by Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John Budde, Pat Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Jen Gentsch, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Dan Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N. Do, Yun Ju Sung, Guoyan Zhao, John C. Morris, Krista Moulder, David M. Holtzman, Randall J. Bateman, Celeste Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E. Schindler, Joyce (Joy) Balls-Berry, Tammie L. S. Benzinger, Richard J. Perrin, Andrea Denny, B. Joy Snider, Susan L. Stark, Laura Ibanez, Carlos Cruchaga

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Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease by Peter R Millar, Brian A Gordon, Julie K Wisch, Stephanie A Schultz, Tammie LS Benzinger, Carlos Cruchaga, Jason J Hassenstab, Laura Ibanez, Celeste Karch, Jorge J Llibre-Guerra, John C Morris, Richard J Perrin, Charlene Supnet-Bell, Chengjie Xiong, Ricardo F Allegri, Sarah B Berman, Jasmeer P Chhatwal, Patricio A Chrem Mendez, Gregory S Day, Anna Hofmann, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Johannes Levin, Francisco Lopera, Yoshiki Niimi, Victor J Sánchez-González, Peter R Schofield, Ana Luisa Sosa-Ortiz, Jonathan Vöglein, for the Dominantly Inherited Alzheimer Network, Randall J Bateman, Beau M Ances, Eric M McDade

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A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype by Jara Cárcel-Márquez, Jara Cárcel-Márquez, Elena Muiño, Cristina Gallego-Fabrega, Cristina Gallego-Fabrega, Natalia Cullell, Natalia Cullell, Miquel Lledós, Laia Llucià-Carol, Laia Llucià-Carol, Tomás Sobrino, Francisco Campos, José Castillo, Marimar Freijo, Juan Francisco Arenillas, Victor Obach, José Álvarez-Sabín, Carlos A. Molina, Marc Ribó, Jordi Jiménez-Conde, Jaume Roquer, Lucia Muñoz-Narbona, Elena Lopez-Cancio, Mònica Millán, Rosa Diaz-Navarro, Cristòfol Vives-Bauza, Gemma Serrano-Heras, Tomás Segura, Laura Ibañez, Laura Heitsch, Laura Heitsch, Pilar Delgado, Rajat Dhar, Jerzy Krupinski, Raquel Delgado-Mederos, Luis Prats-Sánchez, Pol Camps-Renom, Natalia Blay, Lauro Sumoy, Rafael de Cid, Joan Montaner, Carlos Cruchaga, Carlos Cruchaga, Jin-Moo Lee, Joan Martí-Fàbregas, Israel Férnandez-Cadenas

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