HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients by Zhaobo Li, Lihong Zhou, Chrisostomos Prodromou, Velibor Savic, Laurence H. Pearl

Get full text

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands by Matthew Day, Mathieu Rappas, Katie Ptasinska, Dominik Boos, Antony W Oliver, Laurence H Pearl

Get full text

The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90. by Katie L I M Blundell, Mohinder Pal, S Mark Roe, Laurence H Pearl, Chrisostomos Prodromou

Get full text

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint by Nicolas Bigot, Matthew Day, Robert A Baldock, Felicity Z Watts, Antony W Oliver, Laurence H Pearl

Get full text

HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation by Jasmeen Oberoi, Xavi Aran Guiu, Emily A. Outwin, Pascale Schellenberger, Theodoros I. Roumeliotis, Jyoti S. Choudhary, Laurence H. Pearl

Get full text

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX by Robert A. Baldock, Matthew Day, Oliver J. Wilkinson, Ross Cloney, Penelope A. Jeggo, Antony W. Oliver, Felicity Z. Watts, Laurence H. Pearl

Get full text

A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus. by Nicholas E Peters, Brian J Ferguson, Michela Mazzon, Aodhnait S Fahy, Ewelina Krysztofinska, Raquel Arribas-Bosacoma, Laurence H Pearl, Hongwei Ren, Geoffrey L Smith

Get full text

Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus by Angel Rivera-Calzada, Raquel Arribas-Bosacoma, Alba Ruiz-Ramos, Paloma Escudero-Bravo, Jasminka Boskovic, Rafael Fernandez-Leiro, Antony W. Oliver, Laurence H. Pearl, Oscar Llorca

Get full text

Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex by Fabrizio Martino, Mohinder Pal, Hugo Muñoz-Hernández, Carlos F. Rodríguez, Rafael Núñez-Ramírez, David Gil-Carton, Gianluca Degliesposti, J. Mark Skehel, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, Oscar Llorca

Get full text

Specialized interfaces of Smc5/6 control hinge stability and DNA association by Aaron Alt, Hung Q. Dang, Owen S. Wells, Luis M. Polo, Matt A. Smith, Grant A. McGregor, Thomas Welte, Alan R. Lehmann, Laurence H. Pearl, Johanne M. Murray, Antony W. Oliver

Get full text

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System by Stephen T. Hallett, Martyna W. Pastok, R. Marc L. Morgan, Anita Wittner, Katie L.I.M. Blundell, Ildiko Felletar, Stephen R. Wedge, Chrisostomos Prodromou, Martin E.M. Noble, Laurence H. Pearl, Jane A. Endicott

Get full text

TopBP1 utilises a bipartite GINS binding mode to support genome replication by Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A. Barker, Laurence H. Pearl, Antony W. Oliver, Dominik Boos

Get full text

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2 by Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl, Keith W. Caldecott

Get full text

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein by Xiangrong Chen, Yusuf I Ali, Charlotte EL Fisher, Raquel Arribas-Bosacoma, Mohan B Rajasekaran, Gareth Williams, Sarah Walker, Jessica R Booth, Jessica JR Hudson, S Mark Roe, Laurence H Pearl, Simon E Ward, Frances MG Pearl, Antony W Oliver

Get full text