A mixed methods case study investigating how randomised controlled trials (RCTs) are reported, understood and interpreted in practice by Ben E. Byrne, Leila Rooshenas, Helen S. Lambert, Jane M. Blazeby

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74:poster Understanding patients’ views and experiences of NHS services in the context of the Evidence-Based Interventions (EBI) programme in the English National Health Service... by Amanda Owen-Smith, Leila Rooshenas, William Hollingworth, Nicola Farrar, Carmel Conefrey, Josie Morley

Pre-trial qualitative work with health care professionals to refine the design and delivery of a randomised controlled trial on kidney care by Samantha Husbands, Fergus Caskey, Helen Winton, Andy Gibson, Jenny L. Donovan, Leila Rooshenas

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129:oral What are commissioners’ experiences of implementing a national programme seeking to reduce non-evidence-based healthcare in the NHS during the COVID-19 pandemic? by Leila Rooshenas, William Hollingworth, Tim Jones, Joel Glynn, Nicola Farrar, Carmel Conefrey, Josie Morley

Non-COVID-19 UK clinical trials and the COVID-19 pandemic: impact, challenges and possible solutions by Ava Lorenc, Leila Rooshenas, Carmel Conefrey, Julia Wade, Nicola Farrar, Nicola Mills, Sangeetha Paramasivan, Alba Realpe, Marcus Jepson

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Reducing the carbon footprint of research: experience from the NightLife study by Leila Rooshenas, Niamh Quann, Carla Richardson, James O Burton, Helen Eborall, Carmel Conefrey, Katherine L Hull, Steph Burns, Victoria Cluley, Kateryna MacConaill

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Understanding the perspectives of recruiters is key to improving randomised controlled trial enrolment: a qualitative evidence synthesis by Nicola Farrar, Daisy Elliott, Catherine Houghton, Marcus Jepson, Nicola Mills, Sangeetha Paramasivan, Lucy Plumb, Julia Wade, Bridget Young, Jenny L. Donovan, Leila Rooshenas

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What should be included in case report forms? Development and application of novel methods to inform surgical study design: a mixed methods case study in parastomal hernia preventi... by Leila Rooshenas, Timothy Rockall, Neil Smart, Jared Torkington, Natalie S Blencowe, Jane Blazeby, Tom Pinkney, Barnaby Reeves, Charlotte Murkin, Joanne Bennett, I R Daniels, Jamshed Shabbir, Jonathan Randall, H T Brandsma

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Usability of an Automated System for Real-Time Monitoring of Shared Decision-Making for Surgery: Mixed Methods Evaluation by Christin Hoffmann, Kerry Avery, Rhiannon Macefield, Tadeáš Dvořák, Val Snelgrove, Jane Blazeby, Della Hopkins, Shireen Hickey, Ben Gibbison, Leila Rooshenas, Adam Williams, Jonathan Aning, Hilary L Bekker, Angus GK McNair

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Using clinical practice variations as a method for commissioners and clinicians to identify and prioritise opportunities for disinvestment in health care: a cross-sectional study,... by William Hollingworth, Leila Rooshenas, John Busby, Christine E Hine, Padmanabhan Badrinath, Penny F Whiting, Theresa HM Moore, Amanda Owen-Smith, Jonathan AC Sterne, Hayley E Jones, Claire Beynon, Jenny L Donovan

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Development, validation and evaluation of an instrument for active monitoring of men with clinically localised prostate cancer: systematic review, cohort studies and qualitative st... by Andrew J Simpkin, Leila Rooshenas, Julia Wade, Jenny L Donovan, J Athene Lane, Richard M Martin, Chris Metcalfe, Peter C Albertsen, Freddie C Hamdy, Lars Holmberg, David E Neal, Kate Tilling

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147:oral Prioritisation in the United Kingdon national health service during a national emergency: a qualitative case study of surgical teams’ experiences of colorectal cancer surg... by Leila Rooshenas, Baljit Singh, Jane Blazeby, Kerry Avery, Marcus Jepson, Natalie Blencowe, Daisy Elliott, Barry Main, David Messenger, Cynthia Ochieng, James Kinross, Carmel Conefrey, Angus McNair, Jo Bennett, Christin Hoffman, Sarah Squire, Anne Pullybank, Sarah Duff

Did the evidence-based intervention (EBI) programme reduce inappropriate procedures, lessen unwarranted variation or lead to spill-over effects in the National Health Service? by Joel Glynn, Timothy Jones, Mike Bell, Jane Blazeby, Christopher Burton, Carmel Conefrey, Jenny L. Donovan, Nicola Farrar, Josie Morley, Angus McNair, Amanda Owen-Smith, Ellen Rule, Gail Thornton, Victoria Tucker, Iestyn Williams, Leila Rooshenas, William Hollingworth

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Development of a framework to improve the process of recruitment to randomised controlled trials (RCTs): the SEAR (Screened, Eligible, Approached, Randomised) framework by Caroline Wilson, Leila Rooshenas, Sangeetha Paramasivan, Daisy Elliott, Marcus Jepson, Sean Strong, Alison Birtle, David J. Beard, Alison Halliday, Freddie C. Hamdy, Rebecca Lewis, Chris Metcalfe, Chris A. Rogers, Robert C. Stein, Jane M. Blazeby, Jenny L. Donovan

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Cardiorespiratory Optimisation By Arteriovenous fistula Ligation after renal Transplantation (COBALT): study protocol for a multicentre randomised interventional feasibility trial by Madalina Garbi, Leila Rooshenas, Jennifer Banks, James Hunter, Dominic Summers, Matthew Slater, Matthew Bartlett, Anna Sidders, Cara Hudson, Simon Knight, Reza Motallebzadeh, Gavin Pettigrew, Veena Surendrakumar, Andrew Norton, Karl Sylvester, Patrick Mark, Emma Aitken, Aimen Amer, Kirsten Rennie

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The NightLife study — the clinical and cost-effectiveness of thrice-weekly, extended, in-centre nocturnal haemodialysis versus daytime haemodialysis using a mixed methods approach:... by Katherine L. Hull, Kate Bramham, Cassandra L. Brookes, Victoria Cluley, Carmel Conefrey, Nicola J. Cooper, Helen Eborall, James Fotheringham, Matthew P. M. Graham-Brown, Laura J. Gray, Patrick B. Mark, Sandip Mitra, Gavin J. Murphy, Niamh Quann, Leila Rooshenas, Madeleine Warren, James O. Burton

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The high-volume haemodiafiltration vs high-flux haemodialysis registry trial (H4RT): a multi-centre, unblinded, randomised, parallel-group, superiority study to compare the effecti... by Fergus J. Caskey, Sunita Procter, Stephanie J. MacNeill, Julia Wade, Jodi Taylor, Leila Rooshenas, Yumeng Liu, Ammar Annaw, Karen Alloway, Andrew Davenport, Albert Power, Ken Farrington, Sandip Mitra, David C. Wheeler, Kristian Law, Helen Lewis-White, Yoav Ben-Shlomo, Will Hollingworth, Jenny Donovan, J. Athene Lane

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OPTIMA prelim: a randomised feasibility study of personalised care in the treatment of women with early breast cancer by Robert C Stein, Janet A Dunn, John MS Bartlett, Amy F Campbell, Andrea Marshall, Peter Hall, Leila Rooshenas, Adrienne Morgan, Christopher Poole, Sarah E Pinder, David A Cameron, Nigel Stallard, Jenny L Donovan, Christopher McCabe, Luke Hughes-Davies, Andreas Makris, on behalf of the OPTIMA Trial Management Group

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Conveying Equipoise during Recruitment for Clinical Trials: Qualitative Synthesis of Clinicians' Practices across Six Randomised Controlled Trials. by Leila Rooshenas, Daisy Elliott, Julia Wade, Marcus Jepson, Sangeetha Paramasivan, Sean Strong, Caroline Wilson, David Beard, Jane M Blazeby, Alison Birtle, Alison Halliday, Chris A Rogers, Rob Stein, Jenny L Donovan, ACST-2 study group, By-Band-Sleeve study group, Chemorad study group, CSAW study group, Optima prelim study group, POUT study group

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Effectiveness of septoplasty compared to medical management in adults with obstruction associated with a deviated nasal septum: the NAIROS RCT by Sean Carrie, Tony Fouweather, Tara Homer, James O’Hara, Nikki Rousseau, Leila Rooshenas, Alison Bray, Deborah D Stocken, Laura Ternent, Katherine Rennie, Emma Clark, Nichola Waugh, Alison J Steel, Jemima Dooley, Michael Drinnan, David Hamilton, Kelly Lloyd, Yemi Oluboyede, Caroline Wilson, Quentin Gardiner, Naveed Kara, Sadie Khwaja, Samuel Chee Leong, Sangeeta Maini, Jillian Morrison, Paul Nix, Janet A Wilson, M Dawn Teare

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