Leonard P. Guarente

Leonard Pershing Guarente (born 1952) is an American biologist best known for his research on life span extension in the budding yeast ''Saccharomyces cerevisiae'', roundworms (''Caenorhabditis elegans''), and mice. He is a Novartis Professor of Biology at the Massachusetts Institute of Technology. Provided by Wikipedia
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  1. 1
    SIR2 Proteins Regulate Aging in Response to Nutrients

    SIR2 Proteins Regulate Aging in Response to Nutrients by Leonard Guarente

    Published 2001-01-01
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  2. 2
    Increased life span due to calorie restriction in respiratory-deficient yeast.

    Increased life span due to calorie restriction in respiratory-deficient yeast. by Su-Ju Lin, Leonard Guarente

    Published 2006-03-01
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  3. 3
    SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2.

    SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2. by Kayvan Zainabadi, Cassie J Liu, Leonard Guarente

    Published 2017-01-01
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  4. 4
    Cassette for the Generation of Sequential Gene Disruptions in the Yeast Schizosaccharomyces pombe

    Cassette for the Generation of Sequential Gene Disruptions in the Yeast Schizosaccharomyces pombe by David S. McNabb, Sally M. Pak, Leonard Guarente

    Published 1997-06-01
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  5. 5
    Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo.

    Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo. by Anna Bobrowska, Gizem Donmez, Andreas Weiss, Leonard Guarente, Gillian Bates

    Published 2021-01-01
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  6. 6
    SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo.

    SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo. by Anna Bobrowska, Gizem Donmez, Andreas Weiss, Leonard Guarente, Gillian Bates

    Published 2012-01-01
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  7. 7
    Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy.

    Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy. by Angeliki Chalkiadaki, Masaki Igarashi, Armiyaw Sebastian Nasamu, Jovana Knezevic, Leonard Guarente

    Published 2014-07-01
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  8. 8
    SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis.

    SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis. by Kayvan Zainabadi, Cassie J Liu, Alison L M Caldwell, Leonard Guarente

    Published 2017-01-01
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  9. 9
    Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment

    Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment by Caitlin R. Ondracek, Vincent Frappier, Alison E. Ringel, Cynthia Wolberger, Leonard Guarente

    Published 2017-03-01
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  10. 10
    SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

    SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis by Petra Simic, Eric O. Williams, Eric L. Bell, Jing Jing Gong, Michael Bonkowski, Leonard Guarente

    Published 2013-04-01
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  11. 11
    Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency

    Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency by Eric O. Williams, Amy K. Taylor, Eric L. Bell, Rachelle Lim, Daniel M. Kim, Leonard Guarente

    Published 2016-10-01
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  12. 12
    Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

    Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled... by Ryan W. Dellinger, Santiago Roel Santos, Mark Morris, Mal Evans, Dan Alminana, Leonard Guarente, Eric Marcotulli

    Published 2018-08-01
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  13. 13
    Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway

    Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway by Janete Cunha-Santos, Joana Duarte-Neves, Vitor Carmona, Leonard Guarente, Luís Pereira de Almeida, Cláudia Cavadas

    Published 2016-05-01
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  14. 14
    Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

    Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study by Ryan W. Dellinger, Santiago Roel Santos, Mark Morris, Mal Evans, Dan Alminana, Leonard Guarente, Eric Marcotulli

    Published 2017-11-01
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  15. 15
    Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.

    Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. by Laura E Crotty Alexander, Brenda J Marsh, Anjuli M Timmer, Ann E Lin, Kayvan Zainabadi, Agnieszka Czopik, Leonard Guarente, Victor Nizet

    Published 2013-01-01
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  16. 16
    Erratum To: SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin

    Erratum To: SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin by Petra Simic, Kayvan Zainabadi, Eric Bell, David B. Sykes, Borja Saez, Sutada Lotinun, Roland Baron, David Scadden, Ernestina Schipani, Leonard Guarente

    Published 2013-03-01
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  17. 17
    SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin

    SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin by Petra Simic, Kayvan Zainabadi, Eric Bell, David B. Sykes, Borja Saez, Sutada Lotinun, Roland Baron, David Scadden, Ernestina Schipani, Leonard Guarente

    Published 2013-01-01
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  18. 18
    Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ß Cells.

    Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ß Cells. by Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarente

    Published 2006-09-01
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  19. 19
    SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals.

    SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. by Sayaka Akieda-Asai, Nobuhiro Zaima, Koji Ikegami, Tomoaki Kahyo, Ikuko Yao, Takahiro Hatanaka, Shun-Ichiro Iemura, Rika Sugiyama, Takeaki Yokozeki, Yoshinobu Eishi, Morio Koike, Kyoji Ikeda, Takuya Chiba, Haruyoshi Yamaza, Isao Shimokawa, Si-Young Song, Akira Matsuno, Akiko Mizutani, Motoji Sawabe, Moses V Chao, Masashi Tanaka, Yasunori Kanaho, Tohru Natsume, Haruhiko Sugimura, Yukari Date, Michael W McBurney, Leonard Guarente, Mitsutoshi Setou

    Published 2010-01-01
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  20. 20
    Molecular studies of longevity-associated genes in yeast and mammalian cells

    Molecular studies of longevity-associated genes in yeast and mammalian cells by Liszt, Gregory (Gregory Birjandi)

    Published 2008
    Other Authors: “…Leonard Guarente.…”
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