Remote monitoring of amyotrophic lateral sclerosis using wearable sensors detects differences in disease progression and survival: a prospective cohort studyResearch in context by Jordi W.J. van Unnik, Myrte Meyjes, Mark R. Janse van Mantgem, Leonard H. van den Berg, Ruben P.A. van Eijk

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Control in the absence of choice: A qualitative study on decision-making about gastrostomy in people with amyotrophic lateral sclerosis, caregivers, and healthcare professionals. by Remko M van Eenennaam, Neele Rave, Willeke J Kruithof, Esther T Kruitwagen-van Reenen, Leonard H van den Berg, Johanna A Visser-Meily, Anita Beelen

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Brain magnetic resonance imaging of patients with spinal muscular atrophy type 2 and 3 by Marloes Stam, Harold H.G. Tan, Ruben Schmidt, Martijn P. van den Heuvel, Leonard H. van den Berg, Renske I. Wadman, W. Ludo van der Pol

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Acute retigabine‐induced effects on myelinated motor axons in amyotrophic lateral sclerosis by Boudewijn T. H. M. Sleutjes, Diederik J. L. Stikvoort García, Maria O. Kovalchuk, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Hessel Franssen, Leonard H. van denBerg

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Informal Caregivers in Amyotrophic Lateral Sclerosis: A Multi-Centre, Exploratory Study of Burden and Difficulties by Éilís Conroy, Polly Kennedy, Mark Heverin, Iracema Leroi, Emily Mayberry, Anita Beelen, Theocharis Stavroulakis, Leonard H. van den Berg, Christopher J. McDermott, Orla Hardiman, Miriam Galvin

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Living systematic review and comprehensive network meta-analysis of ALS clinical trials: study protocol by Leonard H van den Berg, Dimitris Mavridis, Ruben P A van Eijk, Stavros Nikolakopoulos, Georgios Seitidis, Floris T Van Loon, Jordi W J van Unnik, Daphne N Weemering, Ilianna Bethani

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Discussing Personalized Prognosis Empowers Patients with Amyotrophic Lateral Sclerosis to Regain Control over Their Future: A Qualitative Study by Remko M. van Eenennaam, Loulou S. Koppenol, Willeke J. Kruithof, Esther T. Kruitwagen-van Reenen, Sotice Pieters, Michael A. van Es, Leonard H. van den Berg, Johanna M. A. Visser-Meily, Anita Beelen

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Feasibility and tolerability of multimodal peripheral electrophysiological techniques in a cohort of patients with spinal muscular atrophy by Leandra A.A. Ros, Boudewijn T.H.M. Sleutjes, Diederik J.L. Stikvoort García, H. Stephan Goedee, Fay-Lynn Asselman, Leonard H. van den Berg, W. Ludo van der Pol, Renske I. Wadman

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ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons by Pavol Zelina, Anna Aster de Ruiter, Christy Kolsteeg, Ilona van Ginneken, Harmjan R. Vos, Laura F. Supiot, Boudewijn M. T. Burgering, Frank J. Meye, Jan H. Veldink, Leonard H. van den Berg, R. Jeroen Pasterkamp

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Whole blood transcriptome analysis in amyotrophic lateral sclerosis: A biomarker study. by Wouter van Rheenen, Frank P Diekstra, Oliver Harschnitz, Henk-Jan Westeneng, Kristel R van Eijk, Christiaan G J Saris, Ewout J N Groen, Michael A van Es, Hylke M Blauw, Paul W J van Vught, Jan H Veldink, Leonard H van den Berg

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A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS)... by Flavia L. Lombardo, Stefania Spila Alegiani, Flavia Mayer, Marta Cipriani, Maria Lo Giudice, Albert Christian Ludolph, Christopher J. McDermott, Philippe Corcia, Philip Van Damme, Leonard H. Van den Berg, Orla Hardiman, Gabriele Nicolini, Nicola Vanacore, Brian Dickie, Alberto Albanese, Maria Puopolo, TUDCA-ALS Study Group

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IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset by Kevin Budding, Jeroen W. Bos, Kim Dijkxhoorn, Elisabeth de Zeeuw, Lauri M. Bloemenkamp, Eva M. Zekveld, Ewout J.N. Groen, Bart C. Jacobs, Ruth Huizinga, H. Stephan Goedee, Elisabeth A. Cats, Jeanette H.W. Leusen, Leonard H. van den Berg, C. Erik Hack, W. Ludo van der Pol

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A Road Map for Remote Digital Health Technology for Motor Neuron Disease by Ruben P A van Eijk, Anita Beelen, Esther T Kruitwagen, Deirdre Murray, Ratko Radakovic, Esther Hobson, Liam Knox, Jochem Helleman, Tom Burke, Miguel Ángel Rubio Pérez, Evy Reviers, Angela Genge, Frederik J Steyn, Shyuan Ngo, John Eaglesham, Kit C B Roes, Leonard H van den Berg, Orla Hardiman, Christopher J McDermott

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DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts. by Daria V Zhernakova, Eleonora de Klerk, Harm-Jan Westra, Anastasios Mastrokolias, Shoaib Amini, Yavuz Ariyurek, Rick Jansen, Brenda W Penninx, Jouke J Hottenga, Gonneke Willemsen, Eco J de Geus, Dorret I Boomsma, Jan H Veldink, Leonard H van den Berg, Cisca Wijmenga, Johan T den Dunnen, Gert-Jan B van Ommen, Peter A C 't Hoen, Lude Franke

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Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids by Astrid T. van der Geest, Channa E. Jakobs, Tijana Ljubikj, Christiaan F. M. Huffels, Marta Cañizares Luna, Renata Vieira de Sá, Youri Adolfs, Marina de Wit, Daan H. Rutten, Marthe Kaal, Maria M. Zwartkruis, Mireia Carcolé, Ewout J. N. Groen, Elly M. Hol, Onur Basak, Adrian M. Isaacs, Henk-Jan Westeneng, Leonard H. van den Berg, Jan H. Veldink, Domino K. Schlegel, R. Jeroen Pasterkamp

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Lithium carbonate in amyotrophic lateral sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A: protocol for a confirmatory, randomized, group-sequential, even... by Sean W. Willemse, Kit C. B. Roes, Philip Van Damme, Orla Hardiman, Caroline Ingre, Monica Povedano, Naomi R. Wray, Marleen Gijzen, Mirjam S. de Pagter, Koen C. Demaegd, Annemarie F. C. Janse, Roel G. Vink, Boudewijn T. H. M. Sleutjes, Adriano Chiò, Philippe Corcia, Evy Reviers, Ammar Al-Chalabi, Matthew C. Kiernan, Leonard H. van den Berg, Michael A. van Es, Ruben P. A. van Eijk

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The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases by Zhongbo Chen, Regina H. Reynolds, Antonio F. Pardiñas, Sarah A. Gagliano Taliun, Wouter van Rheenen, Kuang Lin, Aleksey Shatunov, Emil K. Gustavsson, Isabella Fogh, Ashley R. Jones, Wim Robberecht, Philippe Corcia, Adriano Chiò, Pamela J. Shaw, Karen E. Morrison, Jan H. Veldink, Leonard H. van den Berg, Christopher E. Shaw, John F. Powell, Vincenzo Silani, John A. Hardy, Henry Houlden, Michael J. Owen, Martin R. Turner, Mina Ryten, Ammar Al-Chalabi

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Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1 by Restuadi Restuadi, Frederik J. Steyn, Edor Kabashi, Shyuan T. Ngo, Fei-Fei Cheng, Marta F. Nabais, Mike J. Thompson, Ting Qi, Yang Wu, Anjali K. Henders, Leanne Wallace, Chris R. Bye, Bradley J. Turner, Laura Ziser, Susan Mathers, Pamela A. McCombe, Merrilee Needham, David Schultz, Matthew C. Kiernan, Wouter van Rheenen, Leonard H. van den Berg, Jan H. Veldink, Roel Ophoff, Alexander Gusev, Noah Zaitlen, Allan F. McRae, Robert D. Henderson, Naomi R. Wray, Jean Giacomotto, Fleur C. Garton

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Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. by Rudolf S N Fehrmann, Ritsert C Jansen, Jan H Veldink, Harm-Jan Westra, Danny Arends, Marc Jan Bonder, Jingyuan Fu, Patrick Deelen, Harry J M Groen, Asia Smolonska, Rinse K Weersma, Robert M W Hofstra, Wim A Buurman, Sander Rensen, Marcel G M Wolfs, Mathieu Platteel, Alexandra Zhernakova, Clara C Elbers, Eleanora M Festen, Gosia Trynka, Marten H Hofker, Christiaan G J Saris, Roel A Ophoff, Leonard H van den Berg, David A van Heel, Cisca Wijmenga, Gerard J Te Meerman, Lude Franke

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Mutations in the tail and rod domains of the neurofilament heavy‐chain gene increase the risk of ALS by Heather Marriott, Thomas P. Spargo, Ahmad Al Khleifat, Peter M Andersen, Nazli A. Başak, Johnathan Cooper‐Knock, Philippe Corcia, Philippe Couratier, Mamede deCarvalho, Vivian Drory, Marc Gotkine, John E. Landers, Russell McLaughlin, Jesús S. Mora Pardina, Karen E. Morrison, Susana Pinto, Christopher E. Shaw, Pamela J. Shaw, Vincenzo Silani, Nicola Ticozzi, Philip vanDamme, Leonard H. van denBerg, Patrick Vourc'h, Markus Weber, Jan H. Veldink, Project MinE ALS Sequencing Consortium, Richard J. Dobson, Patrick Schwab, Ammar Al‐Chalabi, Alfredo Iacoangeli

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