Li-Huei Tsai

Li-Huei Tsai (; born 18 March 1960) is an American neuroscientist and the director of the Picower Institute for Learning and Memory in the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology.

She is known for her work on neurological disorders that affect learning and memory, particularly for her research on Alzheimer's disease and the role of CDK5 and chromatin remodeling in the progression of the disease. Additionally, her laboratory has innovated numerous applications of induced pluripotent stem cells for ''in vitro'' modeling of neurological diseases. Provided by Wikipedia
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  1. 1
    Innovations in noninvasive sensory stimulation treatments to combat Alzheimer's disease.

    Innovations in noninvasive sensory stimulation treatments to combat Alzheimer's disease. by Jung M Park, Li-Huei Tsai

    Published 2025-02-01
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  2. 2
    Three decades of Cdk5

    Three decades of Cdk5 by Ping-Chieh Pao, Li-Huei Tsai

    Published 2021-11-01
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  3. 3
    Glutamate Receptors in Alzheimer’s Disease: Mechanisms and Therapies

    Glutamate Receptors in Alzheimer’s Disease: Mechanisms and Therapies by Victor Anggono, Li-Huei Tsai, Jürgen Götz

    Published 2016-01-01
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  4. 4
    Profiling DNA break sites and transcriptional changes in response to contextual fear learning.

    Profiling DNA break sites and transcriptional changes in response to contextual fear learning. by Ryan T Stott, Oleg Kritsky, Li-Huei Tsai

    Published 2021-01-01
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  5. 5
    Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics

    Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics by Easwaran Ramamurthy, Gwyneth Welch, Jemmie Cheng, Yixin Yuan, Laura Gunsalus, David A. Bennett, Li-Huei Tsai, Li-Huei Tsai, Andreas R. Pfenning

    Published 2023-01-01
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  6. 6
    Vibrotactile stimulation at gamma frequency mitigates pathology related to neurodegeneration and improves motor function

    Vibrotactile stimulation at gamma frequency mitigates pathology related to neurodegeneration and improves motor function by Ho-Jun Suk, Ho-Jun Suk, Nicole Buie, Nicole Buie, Guojie Xu, Guojie Xu, Arit Banerjee, Arit Banerjee, Edward S. Boyden, Edward S. Boyden, Edward S. Boyden, Edward S. Boyden, Edward S. Boyden, Edward S. Boyden, Edward S. Boyden, Li-Huei Tsai, Li-Huei Tsai, Li-Huei Tsai

    Published 2023-05-01
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  7. 7
    Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes.

    Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes. by Waseem K Raja, Alison E Mungenast, Yuan-Ta Lin, Tak Ko, Fatema Abdurrob, Jinsoo Seo, Li-Huei Tsai

    Published 2016-01-01
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  8. 8
    The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons

    The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons by Hidekuni Yamakawa, Jemmie Cheng, Jay Penney, Fan Gao, Richard Rueda, Jun Wang, Satoko Yamakawa, Oleg Kritskiy, Elizabeta Gjoneska, Li-Huei Tsai

    Published 2017-08-01
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  9. 9
    Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth.

    Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. by David A Davis, Meredith H Wilson, Jodel Giraud, Zhigang Xie, Huang-Chun Tseng, Cheryl England, Haya Herscovitz, Li-Huei Tsai, Ivana Delalle

    Published 2009-10-01
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  10. 10
    Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

    Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution by Hansruedi Mathys, Chinnakkaruppan Adaikkan, Fan Gao, Jennie Z. Young, Elodie Manet, Martin Hemberg, Philip L. De Jager, Richard M. Ransohoff, Aviv Regev, Li-Huei Tsai

    Published 2017-10-01
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  11. 11
    Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations

    Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations by Chinnakkaruppan Adaikkan, Justin Joseph, Georgios Foustoukos, Jun Wang, Denis Polygalov, Roman Boehringer, Steven J. Middleton, Arthur J. Y. Huang, Li-Huei Tsai, Thomas J. McHugh

    Published 2024-03-01
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  12. 12
    Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome

    Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome by Murat Yildirim, Chloe Delepine, Danielle Feldman, Vincent A Pham, Stephanie Chou, Jacque Ip, Alexi Nott, Li-Huei Tsai, Guo-Li Ming, Peter TC So, Mriganka Sur

    Published 2022-07-01
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  13. 13
    Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway.

    Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. by Ji-Song Guan, Susan C Su, Jun Gao, Nadine Joseph, Zhigang Xie, Ying Zhou, Omer Durak, Lei Zhang, J Julius Zhu, Karl R Clauser, Steven A Carr, Li-Huei Tsai

    Published 2011-01-01
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  14. 14
    Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration

    Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration by Nader Morshed, William T Ralvenius, Alexi Nott, L Ashley Watson, Felicia H Rodriguez, Leyla A Akay, Brian A Joughin, Ping‐Chieh Pao, Jay Penney, Lauren LaRocque, Diego Mastroeni, Li‐Huei Tsai, Forest M White

    Published 2020-12-01
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  15. 15
    REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

    REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease by Katharina Meyer, Heather M. Feldman, Tao Lu, Derek Drake, Elaine T. Lim, King-Hwa Ling, Nicholas A. Bishop, Ying Pan, Jinsoo Seo, Yuan-Ta Lin, Susan C. Su, George M. Church, Li-Huei Tsai, Bruce A. Yankner

    Published 2019-01-01
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  16. 16
    PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4

    PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4 by Priyanka Narayan, Grzegorz Sienski, Julia M. Bonner, Yuan-Ta Lin, Jinsoo Seo, Valeriya Baru, Aftabul Haque, Blerta Milo, Leyla A. Akay, Agnese Graziosi, Yelena Freyzon, Dirk Landgraf, William R. Hesse, Julie Valastyan, M. Inmaculada Barrasa, Li-Huei Tsai, Susan Lindquist

    Published 2020-10-01
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  17. 17
    Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia.

    Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia. by Alessandra Bosutti, Jie Qi, Roberta Pennucci, David Bolton, Sabine Matou, Kamela Ali, Li-Huei Tsai, Jerzy Krupinski, Eugene B Petcu, Joan Montaner, Raid Al Baradie, Francesca Caccuri, Arnaldo Caruso, Giulio Alessandri, Shant Kumar, Cristina Rodriguez, Jose Martinez-Gonzalez, Mark Slevin

    Published 2013-01-01
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  18. 18
    HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

    HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease by Ping-Chieh Pao, Debasis Patnaik, L. Ashley Watson, Fan Gao, Ling Pan, Jun Wang, Chinnakkaruppan Adaikkan, Jay Penney, Hugh P. Cam, Wen-Chin Huang, Lorena Pantano, Audrey Lee, Alexi Nott, Trongha X. Phan, Elizabeta Gjoneska, Sara Elmsaouri, Stephen J. Haggarty, Li-Huei Tsai

    Published 2020-05-01
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  19. 19
    Dense, continuous membrane labeling and expansion microscopy visualization of ultrastructure in tissues

    Dense, continuous membrane labeling and expansion microscopy visualization of ultrastructure in tissues by Tay Won Shin, Hao Wang, Chi Zhang, Bobae An, Yangning Lu, Elizabeth Zhang, Xiaotang Lu, Emmanouil D. Karagiannis, Jeong Seuk Kang, Amauche Emenari, Panagiotis Symvoulidis, Shoh Asano, Leanne Lin, Emma K. Costa, IMAXT Grand Challenge Consortium, Adam H. Marblestone, Narayanan Kasthuri, Li-Huei Tsai, Edward S. Boyden

    Published 2025-02-01
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  20. 20
    A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory

    A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory by Rebecca S Mathew, Antonis Tatarakis, Andrii Rudenko, Erin M Johnson-Venkatesh, Yawei J Yang, Elisabeth A Murphy, Travis P Todd, Scott T Schepers, Nertila Siuti, Anthony J Martorell, William A Falls, Sayamwong E Hammack, Christopher A Walsh, Li-Huei Tsai, Hisashi Umemori, Mark E Bouton, Danesh Moazed

    Published 2016-12-01
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