Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci 由 Ellinghaus, D, Jostins, L, Spain, S, Cortes, A, Bethune, J, Han, B, Park, Y, Raychaudhuri, S, Pouget, J, Hübenthal, M, Folseraas, T, Wang, Y, Esko, T, Metspalu, A, Westra, H, Franke, L, Pers, T, Weersma, R, Collij, V, D'Amato, M, Halfvarson, J, Jensen, A, Lieb, W, Degenhardt, F, Forstner, A, Hofmann, A, Schreiber, S, Mrowietz, U, Juran, B, Lazaridis, K, Brunak, S, Dale, A, Trembath, R, Weidinger, S, Weichenthal, M, Ellinghaus, E, Elder, J, Barker, J, Andreassen, O, McGovern, D, Karlsen, T, Barrett, J, Parkes, M, Brown, M, Franke, A

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease 由 Ji, S-G, Juran, BD, Mucha, S, Folseraas, T, Jostins, L, Melum, E, Kumasaka, N, Atkinson, EJ, Schlicht, EM, Liu, JZ, Shah, T, Gutierrez-Achury, J, Boberg, KM, Bergquist, A, Vermeire, S, Eksteen, B, Durie, PR, Farkkila, M, Müller, T, Schramm, C, Sterneck, M, Weismüller, TJ, Gotthardt, DN, Ellinghaus, D, Braun, F, Teufel, A, Laudes, M, Lieb, W, Jacobs, G, Beuers, U, Weersma, RK, Wijmenga, C, Marschall, H-U, Milkiewicz, P, Pares, A, Kontula, K, Chazouillères, O, Invernizzi, P, Goode, E, Spiess, K, Moore, C, Sambrook, J, Ouwehand, WH, Roberts, DJ, Danesh, J, Floreani, A, Gulamhusein, AF, Eaton, JE, Schreiber, S, Chapman, RW, Et al.

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function 由 Wild, PS, Felix, JF, Schillert, A, Teumer, A, Chen, M-H, Leening, MJG, Völker, U, Großmann, V, Brody, JA, Irvin, MR, Shah, SJ, Pramana, S, Lieb, W, Schmidt, R, Stanton, AV, Malzahn, D, Smith, AV, Sundström, J, Minelli, C, Ruggiero, D, Lyytikäinen, L-P, Tiller, D, Smith, JG, Monnereau, C, Di Tullio, MR, Musani, SK, Morrison, AC, Pers, TH, Morley, M, Kleber, ME, Aragam, J, Benjamin, EJ, Bis, JC, Bisping, E, Broeckel, U, Cheng, S, Deckers, JW, Del Greco M, F, Edelmann, F, Fornage, M, Franke, L, Friedrich, N, Harris, TB, Hofer, E, Hofman, A, Huang, J, Hughes, AD, Kähönen, M, investigators, KNHI, Kruppa, J, Lackner, KJ, Lannfelt, L, Laskowski, R, Launer, LJ, Leosdottir, M, Lin, H, Lindgren, CM, Loley, C, MacRae, CA, Mascalzoni, D, Mayet, J, Medenwald, D, Morris, AP, Müller, C, Müller-Nurasyid, M, Nappo, S, Nilsson, PM, Nuding, S, Nutile, T, Peters, A, Pfeufer, A, Pietzner, D, Pramstaller, PP, Raitakari, OT, Rice, KM, Rivadeneira, F, Rotter, JI, Ruohonen, ST, Sacco, RL, Samdarshi, TE, Schmidt, H, Sharp, ASP, Shields, DC, Sorice, R, Sotoodehnia, N, Stricker, BH, Surendran, P, Thom, S, Töglhofer, AM, Uitterlinden, AG, Wachter, R, Völzke, H, Ziegler, A, Münzel, T, März, W, Cappola, TP, Hirschhorn, JN, Mitchell, GF, Smith, NL, Fox, ER, Dueker, ND, Jaddoe, VWV, Melander, O, Russ, M, Lehtimäki, T, Ciullo, M, Hicks, AA, Lind, L, Gudnason, V, Pieske, B, Barron, AJ, Zweiker, R, Schunkert, H, Ingelsson, E, Liu, K, Arnett, DK, Psaty, BM, Blankenberg, S, Larson, MG, Felix, SB, Franco, OH, Zeller, T, Vasan, RS, Dörr, M

Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease 由 Stitziel, N, Stirrups, K, Masca, N, Erdmann, J, Ferrario, P, Koenig, I, Weeke, P, Webb, T, Auer, P, Schick, U, Lu, Y, Zhang, H, Dube, M, Goel, A, Farrall, M, Peloso, G, Won, H, Do, R, van Iperen, E, Kanoni, S, Kruppa, J, Mahajan, A, Scott, R, Willenborg, C, Braund, P, van Capelleveen, J, Doney, A, Donnelly, L, Asselta, R, Merlini, P, Duga, S, Marziliano, N, Denny, J, Shaffer, C, El-Mokhtari, N, Franke, A, Gottesman, O, Heilmann, S, Hengstenberg, C, Hoffmann, P, Holmen, O, Hveem, K, Jansson, J, Joeckel, K, Kessler, T, Kriebel, J, Laugwitz, K, Marouli, E, Martinelli, N, McCarthy, M, Van Zuydam, N, Meisinger, C, Esko, T, Mihailov, E, Escher, SA, Alver, M, Moebus, S, Morris, A, Mueller-Nurasyid, M, Nikpay, M, Olivieri, O, Perreault, L, AlQarawi, A, Robertson, N, Akinsanya, K, Reilly, D, Vogt, T, Yin, W, Asselbergs, F, Kooperberg, C, Jackson, R, Stahl, E, Strauch, K, Varga, T, Waldenberger, M, Zeng, L, Kraja, A, Liu, C, Ehret, G, Newton-Cheh, C, Chasman, D, Chowdhury, R, Ferrario, M, Ford, I, Jukema, J, Kee, F, Kuulasmaa, K, Nordestgaard, BG, Perola, M, Saleheen, D, Sattar, N, Surendran, P, Tregouet, D, Young, R, Howson, J, Butterworth, A, Danesh, J, Ardissino, D, Bottinger, E, Erbel, R, Franks, P, Girelli, D, Hall, A, Hovingh, G, Kastrati, A, Lieb, W, Meitinger, T, Kraus, W, Shah, S, McPherson, R, Orho-Melander, M, Melander, O, Metspalu, A, Palmer, C, Peters, A, Rader, D, Reilly, M, Loos, R, Reiner, A, Roden, D, Tardif, J, Thompson, JR, Wareham, N, Watkins, H, Willer, C, Kathiresan, S, Deloukas, P, Samani, N, Schunkert, H

Systematic evaluation of pleiotropy identifies 6 further loci associated with coronary artery disease 由 Webb, T, Erdmann, J, Stirrups, K, Stitziel, N, Masca, N, Jansen, H, Kanoni, S, Nelson, C, Ferrario, P, König, I, Eicher, J, Johnson, A, Hamby, S, Betsholtz, C, Ruusalepp, A, Franzén, O, Schadt, E, Björkegren, J, Weeke, P, Auer, P, Schick, U, Lu, Y, Zhang, H, Dube, M, Goel, A, Farrall, M, Peloso, G, Won, H, Do, R, van Iperen, E, Kruppa, J, Mahajan, A, Scott, R, Willenborg, C, Braund, P, van Capelleveen, J, Doney, A, Donnelly, L, Asselta, R, Merlini, P, Duga, S, Marziliano, N, Denny, J, Shaffer, C, El-Mokhtari, N, Franke, A, Heilmann, S, Hengstenberg, C, Hoffmann, P, Holmen, O, Hveem, K, Jansson, J, Jöckel, K, Kessler, T, Kriebel, J, Laugwitz, K, Marouli, E, Martinelli, N, McCarthy, M, Van Zuydam, N, Meisinger, C, Esko, T, Mihailov, E, Escher, S, Alver, M, Moebus, S, Morris, A, Virtamo, J, Nikpay, M, Olivieri, O, Provost, S, AlQarawi, A, Robertson, N, Akinsansya, K, Reilly, D, Vogt, T, Yin, W, Asselbergs, F, Kooperberg, C, Jackson, R, Stahl, E, Müller-Nurasyid, M, Strauch, K, Varga, T, Waldenberger, M, Wellcome Trust Case Control Consortium, Zeng, L, Chowdhury, R, Salomaa, V, Ford, I, Jukema, J, Amouyel, P, Kontto, J, MORGAM Investigators, Nordestgaard, B, Ferrières, J, Saleheen, D, Sattar, N, Surendran, P, Wagner, A, Young, R, Howson, J, Butterworth, A, Danesh, J, Ardissino, D, Bottinger, E, Erbel, R, Franks, P, Girelli, D, Hall, A, Hovingh, G, Kastrati, A, Lieb, W, Meitinger, T, Kraus, W, Shah, S, McPherson, R, Orho-Melander, M, Melander, O, Metspalu, A, Palmer, C, Peters, A, Rader, D, Reilly, M, Loos, R, Reiner, A, Roden, D, Tardif, J, Thompson, J, Wareham, N, Watkins, H, Willer, C, Samani, N, Schunkert, H, Deloukas, P, Kathiresan, S, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators

Novel common genetic susceptibility loci for colorectal cancer 由 Schmit, SL, Edlund, CK, Schumacher, FR, Gong, J, Harrison, TA, Huyghe, JR, Qu, C, Melas, M, Van Den Berg, DJ, Wang, H, Tring, S, Plummer, SJ, Albanes, D, Alonso, MH, Amos, CI, Anton, K, Aragaki, AK, Arndt, V, Barry, EL, Berndt, SI, Bezieau, S, Bien, S, Bloomer, A, Boehm, J, Boutron-Ruault, M-C, Brenner, H, Brezina, S, Buchanan, DD, Butterbach, K, Caan, BJ, Campbell, PT, Carlson, CS, Castelao, JE, Chan, AT, Chang-Claude, J, Chanock, SJ, Cheng, I, Cheng, Y-W, Chin, LS, Church, JM, Church, T, Coetzee, GA, Cotterchio, M, Correa, M, Curtis, KR, Duggan, D, Easton, DF, English, D, Feskens, EJM, Fischer, R, Fitzgerald, LM, Fortini, BK, Fritsche, LG, Fuchs, CS, Gago-Dominguez, M, Gala, M, Gallinger, SJ, Gauderman, WJ, Giles, GG, Giovannucci, EL, Gogarten, SM, Gonzalez-Villalpando, C, Gonzalez-Villalpando, EM, Grady, WM, Greenson, JK, Gsur, A, Gunter, M, Haiman, CA, Hampe, J, Harlid, S, Harju, JF, Hayes, RB, Hofer, P, Hoffmeister, M, Hopper, JL, Huang, S-C, Huerta, JM, Hudson, TJ, Hunter, DJ, Idos, GE, Iwasaki, M, Jackson, RD, Jacobs, EJ, Jee, SH, Jenkins, MA, Jia, W-H, Jiao, S, Joshi, AD, Kolonel, LN, Kono, S, Kooperberg, C, Krogh, V, Kuehn, T, Küry, S, Lacroix, A, Laurie, CA, Lejbkowicz, F, Lemire, M, Lenz, H-J, Levine, D, Li, CI, Li, L, Lieb, W, Lin, Y, Lindor, NM, Liu, Y-R, Loupakis, F, Lu, Y, Luh, F, Ma, J, Mancao, C, Manion, FJ, Markowitz, SD, Martin, V, Matsuda, K, Matsuo, K, McDonnell, KJ, McNeil, CE, Milne, R, Molina, AJ, Mukherjee, B, Murphy, N, Newcomb, PA, Offit, K, Omichessan, H, Palli, D, Cotoré, JPP, Pérez-Mayoral, J, Pharoah, PD, Potter, JD, Qu, C, Raskin, L, Rennert, G, Rennert, HS, Riggs, BM, Schafmayer, C, Schoen, RE, Sellers, TA, Seminara, D, Severi, G, Shi, W, Shibata, D, Shu, X-O, Siegel, EM, Slattery, ML, Southey, M, Stadler, ZK, Stern, MC, Stintzing, S, Taverna, D, Thibodeau, SN, Thomas, DC, Trichopoulou, A, Tsugane, S, Ulrich, CM, Van Duijnhoven, FJB, Van Guelpan, B, Vijai, J, Virtamo, J, Weinstein, SJ, White, E, Win, AK, Wolk, A, Woods, M, Wu, AH, Wu, K, Xiang, Y-B, Yen, Y, Zanke, BW, Zeng, Y-X, Zhang, B, Zubair, N, Kweon, S-S, Figueiredo, JC, Zheng, W, Marchand, LL, Lindblom, A, Moreno, V, Peters, U, Casey, G, Hsu, L, Conti, DV, Gruber, SB

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis 由 Lin, K, Pulit, SL, Van Rheenen, W, Shatunov, A, Dekker, AM, McLaughlin, RL, Diekstra, FP, Van Der Spek, RAA, Võsa, U, De Jong, S, Robinson, MR, Yang, J, Fogh, I, Van Doormaal, PT, Tazelaar, GHP, Koppers, M, Blokhuis, AM, Sproviero, W, Jones, AR, Kenna, KP, Van Eijk, KR, Harschnitz, O, Schellevis, RD, Brands, WJ, Medic, J, Menelaou, A, Vajda, A, Ticozzi, N, Rogelj, B, Vrabec, K, Ravnik-Glavač, M, Koritnik, B, Zidar, J, Leonardis, L, Grošelj, LD, Millecamps, S, Salachas, F, Meininger, V, De Carvalho, M, Pinto, S, Mora, JS, Rojas-García, R, Polak, M, Chandran, S, Colville, S, Swingler, R, Morrison, KE, Shaw, PJ, Hardy, J, Orrell, RW, Pittman, A, Sidle, K, Fratta, P, Malaspina, A, Topp, S, Petri, S, Abdulla, S, Drepper, C, Sendtner, M, Meyer, T, Ophoff, RA, Staats, KA, Wiedau-Pazos, M, Lomen-Hoerth, C, Van Deerlin, VM, Trojanowski, JQ, Elman, L, McCluskey, L, Basak, AN, Tunca, C, Hamzeiy, H, Parman, Y, Meitinger, T, Lichtner, P, Radivojkov-Blagojevic, M, Andres, CR, Maurel, C, Bensimon, G, Landwehrmeyer, B, Brice, A, Payan, CAM, Saker-Delye, S, Dürr, A, Wood, NW, Tittmann, L, Lieb, W, Franke, A, Rietschel, M, Cichon, S, Nöthen, MM, Amouyel, P, Tzourio, C, Dartigues, J-F, Uitterlinden, AG, Rivadeneira, F, Estrada, K, Hofman, A, Curtis, C, Blauw, HM, Van Der Kooi, AJ, De Visser, M, Goris, A, Weber, M, Shaw, CE, Smith, BN, Pansarasa, O, Cereda, C, Del Bo, R, Comi, GP, D'Alfonso, S, Bertolin, C, Sorarù, G, Mazzini, L, Pensato, V, Gellera, C, Tiloca, C, Ratti, A, Calvo, A, Moglia, C, Brunetti, M, Arcuti, S, Capozzo, R, Zecca, C, Lunetta, C, Penco, S, Riva, N, Padovani, A, Filosto, M, Muller, B, Stuit, RJ, Registry, P, Slalom Group, Registry, S, Fals Sequencing Consortium, Slagen Consortium, Nnipps Study Group, Blair, I, Zhang, K, McCann, EP, Fifita, JA, Nicholson, GA, Rowe, DB, Pamphlett, R, Kiernan, MC, Grosskreutz, J, Witte, OW, Ringer, T, Prell, T, Stubendorff, B, Kurth, I, Hübner, CA, Leigh, PN, Casale, F, Chio, A, Beghi, E, Pupillo, E, Tortelli, R, Logroscino, G, Powell, J, Ludolph, AC, Weishaupt, JH, Robberecht, W, Van Damme, P, Franke, L, Pers, TH, Brown, RH, Glass, JD, Landers, JE, Hardiman, O, Andersen, PM, Corcia, P, Vourc'H, P, Silani, V, Wray, NR, Visscher, PM, De Bakker, PIW, Van Es, MA, Pasterkamp, RJ, Lewis, CM, Breen, G, Al-Chalabi, A, Van Den Berg, LH, Veldink, JH

Discovery of common and rare genetic risk variants for colorectal cancer 由 Huyghe, JR, Bien, SA, Harrison, TA, Kang, HM, Chen, S, Schmit, SL, Conti, DV, Qu, C, Jeon, J, Edlund, CK, Greenside, P, Wainberg, M, Schumacher, FR, Smith, JD, Levine, DM, Nelson, SC, Sinnott-Armstrong, NA, Albanes, D, Alonso, MH, Anderson, K, Arnau-Collell, C, Arndt, V, Bamia, C, Banbury, BL, Baron, JA, Berndt, SI, Bézieau, S, Bishop, DT, Boehm, J, Boeing, H, Brenner, H, Brezina, S, Buch, S, Buchanan, DD, Burnett-Hartman, A, Butterbach, K, Caan, BJ, Campbell, PT, Carlson, CS, Castellví-Bel, S, Chan, AT, Chang-Claude, J, Chanock, SJ, Chirlaque, M-D, Cho, SH, Connolly, CM, Cross, AJ, Cuk, K, Curtis, KR, De La Chapelle, A, Doheny, KF, Duggan, D, Easton, DF, Elias, SG, Elliott, F, English, DR, Feskens, EJM, Figueiredo, JC, Fischer, R, Fitzgerald, LM, Forman, D, Gala, M, Gallinger, S, Gauderman, WJ, Giles, GG, Gillanders, E, Gong, J, Goodman, PJ, Grady, WM, Grove, JS, Gsur, A, Gunter, MJ, Haile, RW, Hampe, J, Hampel, H, Harlid, S, Hayes, RB, Hofer, P, Hoffmeister, M, Hopper, JL, Hsu, W-L, Huang, W-Y, Hudson, TJ, Hunter, DJ, Ibañez-Sanz, G, Idos, GE, Ingersoll, R, Jackson, RD, Jacobs, EJ, Jenkins, MA, Joshi, AD, Joshu, CE, Keku, TO, Key, TJ, Kim, HR, Kobayashi, E, Kolonel, LN, Kooperberg, C, Kühn, T, Küry, S, Kweon, S-S, Larsson, SC, Laurie, CA, Le Marchand, L, Leal, SM, Lee, SC, Lejbkowicz, F, Lemire, M, Li, CI, Li, L, Lieb, W, Lin, Y, Lindblom, A, Lindor, NM, Ling, H, Louie, TL, Männistö, S, Markowitz, SD, Martín, V, Masala, G, McNeil, CE, Melas, M, Milne, RL, Moreno, L, Murphy, N, Myte, R, Naccarati, A, Newcomb, PA, Offit, K, Ogino, S, Onland-Moret, NC, Pardini, B, Parfrey, PS, Pearlman, R, Perduca, V, Pharoah, PDP, Pinchev, M, Platz, EA, Prentice, RL, Pugh, E, Raskin, L, Rennert, G, Rennert, HS, Riboli, E, Rodríguez-Barranco, M, Romm, J, Sakoda, LC, Schafmayer, C, Schoen, RE, Seminara, D, Shah, M, Shelford, T, Shin, M-H, Shulman, K, Sieri, S, Slattery, ML, Southey, MC, Stadler, ZK, Stegmaier, C, Su, Y-R, Tangen, CM, Thibodeau, SN, Thomas, DC, Thomas, SS, Toland, AE, Trichopoulou, A, Ulrich, CM, Van Den Berg, DJ, Van Duijnhoven, FJB, Van Guelpen, B, Van Kranen, H, Vijai, J, Visvanathan, K, Vodicka, P, Vodickova, L, Vymetalkova, V, Weigl, K, Weinstein, SJ, White, E, Win, AK, Wolf, CR, Wolk, A, Woods, MO, Wu, AH, Zaidi, SH, Zanke, BW, Zhang, Q, Zheng, W, Scacheri, PC, Potter, JD, Bassik, MC, Kundaje, A, Casey, G, Moreno, V, Abecasis, GR, Nickerson, DA, Gruber, SB, Hsu, L, Peters, U

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension 由 Surendran, P, Drenos, F, Young, R, Warren, H, Cook, J, Manning, A, Grarup, N, Sim, X, Barnes, D, Witkowska, K, Staley, J, Tragante, V, Tukiainen, T, Yaghootkar, H, Masca, N, Freitag, D, Ferreira, T, Giannakopoulou, O, Tinker, A, Harakalova, M, Mihailov, E, Liu, C, Kraja, A, Nielsen, S, Rasheed, A, Samuel, M, Zhao, W, Bonnycastle, L, Jackson, A, Narisu, N, Swift, A, Southam, L, Marten, J, Huyghe, J, Stančáková, A, Fava, C, Ohlsson, T, Matchan, A, Stirrups, K, Bork-Jensen, J, Gjesing, A, Kontto, J, Perola, M, Shaw-Hawkins, S, Havulinna, A, Zhang, H, Donnelly, L, Groves, C, Rayner, N, Neville, M, Robertson, N, Yiorkas, A, Herzig, K, Kajantie, E, Zhang, W, Willems, S, Lannfelt, L, Malerba, G, Soranzo, N, Trabetti, E, Verweij, N, Evangelou, E, Moayyeri, A, Vergnaud, A, Nelson, C, Poveda, A, Varga, T, Caslake, M, de Craen, A, Trompet, S, Luan, J, Scott, R, Harris, S, Liewald, D, Marioni, R, Menni, C, Farmaki, A, Hallmans, G, Renström, F, Huffman, J, Hassinen, M, Burgess, S, Vasan, R, Felix, J, Uria-Nickelsen, M, Malarstig, A, Reilly, D, Hoek, M, Vogt, T, Lin, H, Lieb, W, Traylor, M, Markus, H, Highland, H, Justice, A, Marouli, E, Lindström, J, Uusitupa, M, Komulainen, P, Lakka, T, Rauramaa, R, Polasek, O, Rudan, I, Rolandsson, O, Franks, P, Dedoussis, G, Spector, T, Jousilahti, P, Männistö, S, Deary, I, Starr, J, Langenberg, C, Wareham, N, Brown, M, Dominiczak, A, Connell, J, Jukema, J, Sattar, N, Ford, I, Packard, C, Esko, T, Mägi, R, Metspalu, A, de Boer, R, van der Meer, P, van der Harst, P, Gambaro, G, Ingelsson, E, Lind, L, de Bakker, P, Numans, M, Brandslund, I, Christensen, C, Petersen, E, Korpi-Hyövälti, E, Oksa, H, Chambers, J, Kooner, J, Blakemore, A, Franks, S, Jarvelin, M, Husemoen, L, Linneberg, A, Skaaby, T, Thuesen, B, Karpe, F, Tuomilehto, J, Doney, A, Morris, A, Palmer, C, Holmen, O, Hveem, K, Willer, C, Tuomi, T, Groop, L, Käräjämäki, A, Palotie, A, Ripatti, S, Salomaa, V, Alam, D, Majumder, A, Di Angelantonio, E, Chowdhury, R, McCarthy, M, Poulter, N, Stanton, A, Sever, P, Amouyel, P, Arveiler, D, Blankenberg, S, Ferrières, J, Kee, F, Kuulasmaa, K, Müller-Nurasyid, M, Veronesi, G, Virtamo, J, Deloukas, P, Elliott, P, Zeggini, E, Kathiresan, S, Melander, O, Kuusisto, J, Laakso, M, Padmanabhan, S, Porteous, D, Hayward, C, Scotland, G, Collins, F, Mohlke, K, Hansen, T, Pedersen, O, Boehnke, M, Stringham, H, Frossard, P, Newton-Cheh, C, Tobin, M, Nordestgaard, B, Caulfield, M, Mahajan, A, Morris, A, Tomaszewski, M, Samani, N, Saleheen, D, Asselbergs, F, Lindgren, C, Danesh, J, Wain, L, Butterworth, A, Howson, J, Munroe, P