Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases by Lippl, K

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases by Lippl, K, Abboud, M, Loenarz, C, Schofield, C

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain by Abboud, M, Chowdhury, R, Leung, I, Lippl, K, Loenarz, C, Claridge, T, Schofield, C

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens by Lippl, K, Boleininger, A, McDonough, M, Abboud, M, Tarhonskaya, H, Chowdhury, R, Loenarz, C, Schofield, C

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors by Holt-Martyn, J, Tumber, A, Rahman, M, Lippl, K, Figg, W, McDonough, M, Chowdhury, R, Schofield, C

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases by Chan, M, Ilott, N, Schödel, J, Sims, D, Tumber, A, Lippl, K, Mole, D, Pugh, C, Ratcliffe, P, Ponting, C, Schofield, C

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates by Cockman, M, Lippl, K, Tian, Y, Pegg, H, Figg, W, Abboud, M, Heilig, R, Fischer, R, Myllyharju, J, Schofield, C, Ratcliffe, P

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii by Liu, T, Abboud, MI, Chowdhury, R, Tumber, A, Hardy, AP, Lippl, K, Lohans, CT, Pires, E, Wickens, J, McDonough, MA, West, CM, Schofield, CJ

2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2 by Abboud, M, McAllister, T, Leung, I, Chowdhury, R, Jorgensen, C, Domene, C, Mecinović, J, Lippl,, K, Hancock, R, Hopkinson, R, Kawamura, A, Claridge, T, Schofield, C

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors by Holt-Martyn, JP, Chowdhury, R, Tumber, A, Yeh, T-L, Abboud, MI, Lippl, K, Lohans, CT, Langley, GW, Figg Jr, W, McDonough, MA, Pugh, CW, Ratcliffe, PJ, Schofield, CJ

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials by Yeh, TL, Leissing, TM, Abboud, M, Thinnes, CC, Atasoylu, O, Holt-Martyn, JP, Zhang, D, Tumber, A, Lippl, K, Lohans, CT, Leung, IKH, Morcrette, H, Kawamura, A, Flashman, E, Lu, X, Ratcliffe, P, Chowdhury, R, Pugh, C, Schofield, C

The clinically used iron chelator deferasirox is an inhibitor of epigenetic jumonjiC domain-containing histone demethylases by Roatsch, M, Hoffmann, I, Abboud, MI, Hancock, RL, Tarhonskaya, H, Hsu, K-F, Wilkins, SE, Yeh, T-L, Lippl, K, Serrer, K, Moneke, I, Ahrens, TD, Robaa, D, Wenzler, S, Barthes, NPF, Franz, H, Sippl, W, Lassmann, S, Diederichs, S, Schleicher, E, Schofield, CJ, Kawamura, A, Schüle, R, Jung, M