An update of clinical issues from InSIGHT 2011 by Lipton L

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The multiple colorectal adenoma phenotype and MYH, a base excision repair gene. by Lipton, L, Tomlinson, I

The genetics of FAP and FAP-like syndromes. by Lipton, L, Tomlinson, I

Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy? by Sieber, O, Lipton, L, Heinimann, K, Tomlinson, I

Germline mutations in the TGF-beta and Wnt signalling pathways are a rare cause of the "multiple" adenoma phenotype. by Lipton, L, Sieber, O, Thomas, H, Hodgson, S, Tomlinson, I, Woodford-Richens, K

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma. by Lipton, L, Fleischmann, C, Sieber, O, Thomas, H, Hodgson, S, Tomlinson, I, Houlston, R

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers. by Halford, SE, Rowan, A, Lipton, L, Sieber, O, Pack, K, Thomas, H, Hodgson, S, Bodmer, W, Tomlinson, I

Prognostic value of chronic inflammatory cell infiltrates in Dukes stage B and C colorectal cancer. by Christie, M, Prakash, S, Jorissen, R, Sakthianandeswaren, A, Gibbs, P, Lipton, L, Desai, J, Tie, J, Kerr, D, Sieber, O

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients. by Crabtree, M, Sieber, O, Lipton, L, Hodgson, S, Lamlum, H, Thomas, H, Neale, K, Phillips, R, Heinimann, K, Tomlinson, I

Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC... by Johnson, V, Lipton, L, Cummings, C, Eftekhar Sadat, A, Izatt, L, Hodgson, S, Talbot, I, Thomas, H, Silver, A, Tomlinson, I

Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients. by Enholm, S, Hienonen, T, Suomalainen, A, Lipton, L, Tomlinson, I, Kärjä, V, Eskelinen, M, Mecklin, J, Karhu, A, Järvinen, H, Aaltonen, L

Apparent Mendelian inheritance of breast and colorectal cancer: chance, genetic heterogeneity or a new gene? by Lipton, L, Thomas, H, Eeles, R, Houlston, R, Longmuir, M, Davison, R, Hodgson, S, Murday, V, Norbury, C, Taylor, C, Tomlinson, I

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. by Sieber, O, Lipton, L, Crabtree, M, Heinimann, K, Fidalgo, P, Phillips, R, Bisgaard, M, Orntoft, T, Aaltonen, L, Hodgson, S, Thomas, H, Tomlinson, I

Refining the Amsterdam Criteria and Bethesda Guidelines: testing algorithms for the prediction of mismatch repair mutation status in the familial cancer clinic. by Lipton, L, Johnson, V, Cummings, C, Fisher, S, Risby, P, Eftekhar Sadat, A, Cranston, T, Izatt, L, Sasieni, P, Hodgson, S, Thomas, H, Tomlinson, I

Audit of routine immunohistochemistry testing for mismatch repair proteins at diagnosis of colorectal cancer under the age of 50 by Lipton L, Kentwell M, Li M, Williams D, Christie M, Landgren A, Dow C, Jones I, McLaughlin S, Delatycki M, Macrae F, Lynch E

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A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history. by Truta, B, Allen, B, Conrad, P, Weinberg, V, Miller, G, Pomponio, R, Lipton, L, Guerra, G, Tomlinson, I, Sleisenger, M, Kim, Y, Terdiman, J

A family with juvenile polyposis linked to the BMPR1A locus: cryptic mutation or closely linked gene? by Chow, E, Lipton, L, Carvajal-Carmona, L, Arthur, G, Bhathal, P, Kaur, G, Jaeger, E, Woodford-Richens, K, Howarth, K, Tomlinson, I, Macrae, F

The TERT variant rs2736100 is associated with colorectal cancer risk. by Kinnersley, B, Migliorini, G, Broderick, P, Whiffin, N, Dobbins, SE, Casey, G, Hopper, J, Sieber, O, Lipton, L, Kerr, D, Dunlop, MG, Tomlinson, I, Houlston, R

The TERT variant rs2736100 is associated with colorectal cancer risk by Kinnersley, B, Migliorini, G, Broderick, P, Whiffin, N, Dobbins, SE, Casey, G, Hopper, J, Sieber, O, Lipton, L, Kerr, D, Dunlop, MG, Tomlinson, I, Houlston, R

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway. by Lipton, L, Halford, SE, Johnson, V, Novelli, MR, Jones, A, Cummings, C, Barclay, E, Sieber, O, Sadat, A, Bisgaard, M, Hodgson, S, Aaltonen, L, Thomas, H, Tomlinson, I