An update of clinical issues from InSIGHT 2011 מאת Lipton L

קבל טקסט מלא

The multiple colorectal adenoma phenotype and MYH, a base excision repair gene. מאת Lipton, L, Tomlinson, I

The genetics of FAP and FAP-like syndromes. מאת Lipton, L, Tomlinson, I

Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy? מאת Sieber, O, Lipton, L, Heinimann, K, Tomlinson, I

Germline mutations in the TGF-beta and Wnt signalling pathways are a rare cause of the "multiple" adenoma phenotype. מאת Lipton, L, Sieber, O, Thomas, H, Hodgson, S, Tomlinson, I, Woodford-Richens, K

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma. מאת Lipton, L, Fleischmann, C, Sieber, O, Thomas, H, Hodgson, S, Tomlinson, I, Houlston, R

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers. מאת Halford, SE, Rowan, A, Lipton, L, Sieber, O, Pack, K, Thomas, H, Hodgson, S, Bodmer, W, Tomlinson, I

Prognostic value of chronic inflammatory cell infiltrates in Dukes stage B and C colorectal cancer. מאת Christie, M, Prakash, S, Jorissen, R, Sakthianandeswaren, A, Gibbs, P, Lipton, L, Desai, J, Tie, J, Kerr, D, Sieber, O

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients. מאת Crabtree, M, Sieber, O, Lipton, L, Hodgson, S, Lamlum, H, Thomas, H, Neale, K, Phillips, R, Heinimann, K, Tomlinson, I

Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC... מאת Johnson, V, Lipton, L, Cummings, C, Eftekhar Sadat, A, Izatt, L, Hodgson, S, Talbot, I, Thomas, H, Silver, A, Tomlinson, I

Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients. מאת Enholm, S, Hienonen, T, Suomalainen, A, Lipton, L, Tomlinson, I, Kärjä, V, Eskelinen, M, Mecklin, J, Karhu, A, Järvinen, H, Aaltonen, L

Apparent Mendelian inheritance of breast and colorectal cancer: chance, genetic heterogeneity or a new gene? מאת Lipton, L, Thomas, H, Eeles, R, Houlston, R, Longmuir, M, Davison, R, Hodgson, S, Murday, V, Norbury, C, Taylor, C, Tomlinson, I

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. מאת Sieber, O, Lipton, L, Crabtree, M, Heinimann, K, Fidalgo, P, Phillips, R, Bisgaard, M, Orntoft, T, Aaltonen, L, Hodgson, S, Thomas, H, Tomlinson, I

Refining the Amsterdam Criteria and Bethesda Guidelines: testing algorithms for the prediction of mismatch repair mutation status in the familial cancer clinic. מאת Lipton, L, Johnson, V, Cummings, C, Fisher, S, Risby, P, Eftekhar Sadat, A, Cranston, T, Izatt, L, Sasieni, P, Hodgson, S, Thomas, H, Tomlinson, I

Audit of routine immunohistochemistry testing for mismatch repair proteins at diagnosis of colorectal cancer under the age of 50 מאת Lipton L, Kentwell M, Li M, Williams D, Christie M, Landgren A, Dow C, Jones I, McLaughlin S, Delatycki M, Macrae F, Lynch E

קבל טקסט מלא

A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history. מאת Truta, B, Allen, B, Conrad, P, Weinberg, V, Miller, G, Pomponio, R, Lipton, L, Guerra, G, Tomlinson, I, Sleisenger, M, Kim, Y, Terdiman, J

A family with juvenile polyposis linked to the BMPR1A locus: cryptic mutation or closely linked gene? מאת Chow, E, Lipton, L, Carvajal-Carmona, L, Arthur, G, Bhathal, P, Kaur, G, Jaeger, E, Woodford-Richens, K, Howarth, K, Tomlinson, I, Macrae, F

The TERT variant rs2736100 is associated with colorectal cancer risk. מאת Kinnersley, B, Migliorini, G, Broderick, P, Whiffin, N, Dobbins, SE, Casey, G, Hopper, J, Sieber, O, Lipton, L, Kerr, D, Dunlop, MG, Tomlinson, I, Houlston, R

The TERT variant rs2736100 is associated with colorectal cancer risk מאת Kinnersley, B, Migliorini, G, Broderick, P, Whiffin, N, Dobbins, SE, Casey, G, Hopper, J, Sieber, O, Lipton, L, Kerr, D, Dunlop, MG, Tomlinson, I, Houlston, R

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway. מאת Lipton, L, Halford, SE, Johnson, V, Novelli, MR, Jones, A, Cummings, C, Barclay, E, Sieber, O, Sadat, A, Bisgaard, M, Hodgson, S, Aaltonen, L, Thomas, H, Tomlinson, I