An update of clinical issues from InSIGHT 2011 由 Lipton L

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The multiple colorectal adenoma phenotype and MYH, a base excision repair gene. 由 Lipton, L, Tomlinson, I

The genetics of FAP and FAP-like syndromes. 由 Lipton, L, Tomlinson, I

Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy? 由 Sieber, O, Lipton, L, Heinimann, K, Tomlinson, I

Germline mutations in the TGF-beta and Wnt signalling pathways are a rare cause of the "multiple" adenoma phenotype. 由 Lipton, L, Sieber, O, Thomas, H, Hodgson, S, Tomlinson, I, Woodford-Richens, K

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma. 由 Lipton, L, Fleischmann, C, Sieber, O, Thomas, H, Hodgson, S, Tomlinson, I, Houlston, R

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers. 由 Halford, SE, Rowan, A, Lipton, L, Sieber, O, Pack, K, Thomas, H, Hodgson, S, Bodmer, W, Tomlinson, I

Prognostic value of chronic inflammatory cell infiltrates in Dukes stage B and C colorectal cancer. 由 Christie, M, Prakash, S, Jorissen, R, Sakthianandeswaren, A, Gibbs, P, Lipton, L, Desai, J, Tie, J, Kerr, D, Sieber, O

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients. 由 Crabtree, M, Sieber, O, Lipton, L, Hodgson, S, Lamlum, H, Thomas, H, Neale, K, Phillips, R, Heinimann, K, Tomlinson, I

Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC... 由 Johnson, V, Lipton, L, Cummings, C, Eftekhar Sadat, A, Izatt, L, Hodgson, S, Talbot, I, Thomas, H, Silver, A, Tomlinson, I

Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients. 由 Enholm, S, Hienonen, T, Suomalainen, A, Lipton, L, Tomlinson, I, Kärjä, V, Eskelinen, M, Mecklin, J, Karhu, A, Järvinen, H, Aaltonen, L

Apparent Mendelian inheritance of breast and colorectal cancer: chance, genetic heterogeneity or a new gene? 由 Lipton, L, Thomas, H, Eeles, R, Houlston, R, Longmuir, M, Davison, R, Hodgson, S, Murday, V, Norbury, C, Taylor, C, Tomlinson, I

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. 由 Sieber, O, Lipton, L, Crabtree, M, Heinimann, K, Fidalgo, P, Phillips, R, Bisgaard, M, Orntoft, T, Aaltonen, L, Hodgson, S, Thomas, H, Tomlinson, I

Refining the Amsterdam Criteria and Bethesda Guidelines: testing algorithms for the prediction of mismatch repair mutation status in the familial cancer clinic. 由 Lipton, L, Johnson, V, Cummings, C, Fisher, S, Risby, P, Eftekhar Sadat, A, Cranston, T, Izatt, L, Sasieni, P, Hodgson, S, Thomas, H, Tomlinson, I

Audit of routine immunohistochemistry testing for mismatch repair proteins at diagnosis of colorectal cancer under the age of 50 由 Lipton L, Kentwell M, Li M, Williams D, Christie M, Landgren A, Dow C, Jones I, McLaughlin S, Delatycki M, Macrae F, Lynch E

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A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history. 由 Truta, B, Allen, B, Conrad, P, Weinberg, V, Miller, G, Pomponio, R, Lipton, L, Guerra, G, Tomlinson, I, Sleisenger, M, Kim, Y, Terdiman, J

A family with juvenile polyposis linked to the BMPR1A locus: cryptic mutation or closely linked gene? 由 Chow, E, Lipton, L, Carvajal-Carmona, L, Arthur, G, Bhathal, P, Kaur, G, Jaeger, E, Woodford-Richens, K, Howarth, K, Tomlinson, I, Macrae, F

The TERT variant rs2736100 is associated with colorectal cancer risk. 由 Kinnersley, B, Migliorini, G, Broderick, P, Whiffin, N, Dobbins, SE, Casey, G, Hopper, J, Sieber, O, Lipton, L, Kerr, D, Dunlop, MG, Tomlinson, I, Houlston, R

The TERT variant rs2736100 is associated with colorectal cancer risk 由 Kinnersley, B, Migliorini, G, Broderick, P, Whiffin, N, Dobbins, SE, Casey, G, Hopper, J, Sieber, O, Lipton, L, Kerr, D, Dunlop, MG, Tomlinson, I, Houlston, R

Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway. 由 Lipton, L, Halford, SE, Johnson, V, Novelli, MR, Jones, A, Cummings, C, Barclay, E, Sieber, O, Sadat, A, Bisgaard, M, Hodgson, S, Aaltonen, L, Thomas, H, Tomlinson, I